Results 11 to 20 of about 23,738 (171)
Echinococcus multilocularis Calreticulin Interferes with C1q-Mediated Complement Activation
Tropical Medicine and Infectious Disease, 2023 As a zoonotic disease caused by Echinococcus multilocularis larvae, alveolar echinococcosis (AE) is one of the most severe forms of parasitic infection. Over a long evolutional process E.
Siqi Xian +8 more
doaj +3 more sources
Emerging and novel functions of complement protein C1q [PDF]
Frontiers in Immunology, 2015 Complement protein C1q, the recognition subcomponent of the classical pathway, performs a diverse range of complement and non-complement functions. It can bind various ligands derived from self, non-self and altered-self and modulate the functions of ...
Lubna eKouser +6 more
doaj +5 more sources
Complement, C1q, and C1q-related molecules regulate macrophage polarization [PDF]
Frontiers in Immunology, 2014 Complement is a critical system of enzymes, regulatory proteins and receptors that regulates both innate and adaptive immune responses. Natural mutations in complement molecules highlight their requirement in regulation of a variety of human conditions ...
Suzanne Slater Bohlson +4 more
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Prognostic Implications of the Complement Protein C1q in Gliomas [PDF]
Frontiers in Immunology, 2019 The contribution of the complement system in the pathophysiology of brain cancers has been recently considered in light of its well-known involvement in carcinogenesis.
Alessandro Mangogna +10 more
doaj +6 more sources
Autoantibodies against complement component C1q in systemic lupus erythematosus [PDF]
Clinical & Translational Immunology, 2021 Systemic lupus erythematosus (SLE) is the archetype of a systemic autoimmune disease, but the multifaceted pathogenic mechanisms leading to inflammation and organ damage are not fully understood.
Marten Trendelenburg
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Epigenetic regulation of complement C1Q gene expression. [PDF]
Front ImmunolHuman C1q is a multifaceted complement protein whose functions range from activating the complement classical pathway to immunomodulation and promoting placental development and tumorigenesis. It is encoded by the C1QA, C1QB, and C1QC genes located on chromosome 1.
Pegoraro S +6 more
europepmc +6 more sources
Foods, 2023 The complement pathway is a major component of the innate immune system, which is critical for recognizing and clearing pathogens that rapidly react to defend the body against external pathogens.
Yihang Xing +8 more
doaj +1 more source
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Autoantibodies against Complement C1q Specifically Target C1q Bound on Early Apoptotic Cells [PDF]
The Journal of Immunology, 2009 AbstractAutoantibodies against complement C1q (anti-C1q) are frequently found in patients with systemic lupus erythematosus (SLE). They strongly correlate with the occurrence of severe lupus nephritis, suggesting a pathogenic role in SLE. Because anti-C1q are known to recognize a neoepitope on bound C1q, but not on fluid-phase C1q, the aim of this ...
Bigler, Cornelia +4 more
openaire +2 more sources
Complement in Renal Disease as a Potential Contributor to Arterial Hypertension
Kidney & Blood Pressure Research, 2021 Objective: Complement deposition is prevalent in kidney biopsies of patients with arterial hypertension and hypertensive nephropathy, but an association of hypertension and complement deposition or involvement of complement in the pathogenesis of ...
Lisa-Maren Fischer +6 more
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