Results 11 to 20 of about 40,238 (270)
MafB is a critical regulator of complement component C1q [PDF]
Nature Communications, 2017 The transcription factor MafB is expressed by monocytes and macrophages. Efferocytosis (apoptotic cell uptake) by macrophages is important for inhibiting the development of autoimmune diseases, and is greatly reduced in Mafb-deficient macrophages.
Andrea Christina-Sylvia +24 more
core +6 more sources
Emerging and novel functions of complement protein C1q [PDF]
Frontiers in Immunology, 2015 Complement protein C1q, the recognition subcomponent of the classical pathway, performs a diverse range of complement and non-complement functions. It can bind various ligands derived from self, non-self and altered-self and modulate the functions of ...
Lubna eKouser +6 more
doaj +6 more sources
Prognostic Implications of the Complement Protein C1q in Gliomas [PDF]
Frontiers in Immunology, 2019 The contribution of the complement system in the pathophysiology of brain cancers has been recently considered in light of its well-known involvement in carcinogenesis.
Alessandro Mangogna +10 more
doaj +7 more sources
Complement, C1q, and C1q-related molecules regulate macrophage polarization [PDF]
Frontiers in Immunology, 2014 Complement is a critical system of enzymes, regulatory proteins and receptors that regulates both innate and adaptive immune responses. Natural mutations in complement molecules highlight their requirement in regulation of a variety of human conditions ...
Suzanne Slater Bohlson +4 more
doaj +4 more sources
Complement Protein C1q Interacts with DC-SIGN via Its Globular Domain and Thus May Interfere with HIV-1 Transmission [PDF]
, 2016 Dendritic Cells (DCs) are the most potent antigen presenting cells capable of priming naïve T cells. Its C-type lectin receptor, DC-SIGN, regulates a wide range of immune functions.
Lina Pednekar +9 more
openalex +4 more sources
Fibronectin binds to the C1q component of complement. [PDF]
Proceedings of the National Academy of Sciences, 1982 Fibronectin immobilized to plastic tubes binds soluble C1q with a Kd of 82 +/- 2.6 nM. The binding of fibronectin to C1q is relatively insensitive to pH but is sensitive to ionic conditions. C1q covalently bound to Sepharose selectively binds cellular fibronectin produced by a hamster fibroblast cell line.
David H. Bing +4 more
openalex +4 more sources
Mapping of the complement C1q binding site on Trichinella spiralis paramyosin [PDF]
Parasites & Vectors, 2018 Background Trichinella spiralis is a tissue-dwelling parasite has developed the ability to evade the host immune attack to establish parasitism in a host.
Zixia Wang +5 more
doaj +2 more sources
Epigenetic regulation of complement C1Q gene expression. [PDF]
Front ImmunolHuman C1q is a multifaceted complement protein whose functions range from activating the complement classical pathway to immunomodulation and promoting placental development and tumorigenesis. It is encoded by the C1QA, C1QB, and C1QC genes located on chromosome 1.
Pegoraro S +6 more
europepmc +4 more sources
C1q as a target molecule to treat human disease: What do mouse studies teach us?
Frontiers in Immunology, 2022 The complement system is a field of growing interest for pharmacological intervention. Complement protein C1q, the pattern recognition molecule at the start of the classical pathway of the complement cascade, is a versatile molecule with additional non ...
Kristina Schulz +3 more
doaj +1 more source
Foods, 2023 The complement pathway is a major component of the innate immune system, which is critical for recognizing and clearing pathogens that rapidly react to defend the body against external pathogens.
Yihang Xing +8 more
doaj +1 more source