Results 41 to 50 of about 41,630 (234)
Trichinella spiralis Calreticulin Binds Human Complement C1q As an Immune Evasion Strategy
Frontiers in Immunology, 2017 As a multicellular parasitic nematode, Trichinella spiralis regulates host immune responses by producing a variety of immunomodulatory molecules to escape from host immune attack, but the mechanisms underlying the immune evasion are not well understood ...
Limei Zhao +13 more
doaj +1 more source
Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]
, 2013 This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Abdul-Aziz, M +5 more
core +1 more source
Role of collectins and complement protein C1q in pregnancy and parturition [PDF]
Immunobiology, 2016 Collectins such as surfactant proteins SP-A, SP-D, and mannan-binding lectin (MBL), as well as complement protein C1q are evolutionarily conserved innate immune molecules. They are known to opsonize a range of microbial pathogens (bacteria, fungi, virus, and parasites) and trigger effector clearance mechanisms involving phagocytosis and/or complement ...
Shanmuga Priyaa Madhukaran +5 more
openaire +4 more sources
Complement Activation-Independent Attenuation of SARS-CoV-2 Infection by C1q and C4b-Binding Protein
Viruses, 2023 The complement system is a key component of the innate immune response to viruses and proinflammatory events. Exaggerated complement activation has been attributed to the induction of a cytokine storm in severe SARS-CoV-2 infection.
Nazar Beirag +9 more
doaj +1 more source
Fibronectin binds to the C1q component of complement. [PDF]
Proceedings of the National Academy of Sciences, 1982 Fibronectin immobilized to plastic tubes binds soluble C1q with a Kd of 82 +/- 2.6 nM. The binding of fibronectin to C1q is relatively insensitive to pH but is sensitive to ionic conditions. C1q covalently bound to Sepharose selectively binds cellular fibronectin produced by a hamster fibroblast cell line.
D H, Bing +4 more
openaire +2 more sources
Soluble gC1qR is an autocrine signal that induces B1R expression on endothelial cells [PDF]
, 2013 Bradykinin (BK) is one of the most potent vasodilator agonists known and belongs to the kinin family of proinflammatory peptides. BK induces its activity via two G protein-coupled receptors: BK receptor 1 (B1R) and BK receptor 2.
David, H +10 more
core +2 more sources
Complement C1q expression in Erythema nodosum leprosum
PLOS Neglected Tropical Diseases, 2018 Complement C1q is a soluble protein capable of initiating components of the classical pathway in host defence system. In earlier qualitative studies, C1q has been implicated in the pathogenesis of Erythema Nodosum Leprosum (ENL). However, little is known about the role of this complement in ENL reaction.
Edessa Negera +5 more
openaire +4 more sources
Frontiers in Immunology, 2018 IgG antibodies (Abs) mediate their effector functions through the interaction with Fcγ receptors (FcγRs) and the complement factors. The main IgG-mediated complement activation pathway is induced through the binding of complement C1q to IgG Abs.
Gina-Maria Lilienthal +7 more
doaj +1 more source
Clinical impact of complement (C1q, C3d) binding De Novo donor-specific HLA antibody in kidney transplant recipients. [PDF]
PLoS ONE, 2018 INTRODUCTION:Complement binding activity of donor-specific HLA antibodies (DSA) has been suggested as a new tool to stratify immunologic risk in kidney transplantation (KT).
Hyeyoung Lee +7 more
doaj +1 more source
LifeThe interaction between IgM and C1q represents the first step of the classical pathway of the complement system in higher vertebrates. To identify the significance of particular IgM/C1q interactions, recombinant IgMs were used in both hexameric and ...
Maria Magdalena John +4 more
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