Results 51 to 60 of about 41,630 (234)

Complement is dispensable for neurodegeneration in Niemann-Pick disease type C

Journal of Neuroinflammation, 2012
Background The immune system has been implicated in neurodegeneration during development and disease. In various studies, the absence of complement (that is, C1q deficiency) impeded the elimination of apoptotic neurons, allowing survival.
Lopez Manuel E, Klein Andres D, Scott Matthew P   +2 more
doaj   +1 more source

Clinical risk stratification of paediatric renal transplant recipients using C1q and C3d fixing of de novo donor-specific antibodies [PDF]

, 2017
Introduction: We have previously shown that children who developed de novo donor-specific human leukocyte antigen (HLA) antibodies (DSA) had greater decline in allograft function.
A Fearn, A Fichtner, A Loupy, A Sicard, Anthony Dorling, AR Tambur, BD Tait, C Dorje, C Dudley, C Lefaucheur, Chloe Martin, DB Jose Pinheiro, EF Reed, George Michaelides, JJ Kim, JJ Kim, Jon Jin Kim, KA Thomas, L Krischock, L Rees, LD Cornell, M Nangaku, N Lachmann, Neil J. Sebire, Nizam Mamode, O Aubert, Olivia Shaw, P Comoli, P Cravedi, R Lv, Ramnath Balasubramaniam, RC Walsh, Robert Vaughan, S Schaub, Stephen D. Marks, VR Dharnidharka   +35 more
core   +3 more sources

The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA

Cell Reports, 2019
Summary: Movement is an essential behavior requiring the assembly and refinement of spinal motor circuits. However, the mechanisms responsible for circuit refinement and synapse maintenance are poorly understood.
Aleksandra Vukojicic, Nicolas Delestrée, Emily V. Fletcher, John G. Pagiazitis, Sethu Sankaranarayanan, Ted A. Yednock, Ben A. Barres, George Z. Mentis   +7 more
doaj   +1 more source

Autoantibodies against Complement C1q Specifically Target C1q Bound on Early Apoptotic Cells [PDF]

The Journal of Immunology, 2009
Abstract Autoantibodies against complement C1q (anti-C1q) are frequently found in patients with systemic lupus erythematosus (SLE). They strongly correlate with the occurrence of severe lupus nephritis, suggesting a pathogenic role in SLE.
Bigler, Cornelia, Schaller, Monica, Perahud, Iryna, Osthoff, Michael, Trendelenburg, Marten   +4 more
openaire   +3 more sources

Rheumatologic Manifestations of Patients With Type B Insulin Resistance

Arthritis Care &Research, EarlyView.
Objective The objectives of this study were to identify laboratory and clinical features associated with type B insulin resistance (TBIR), a rare condition caused by autoantibodies that inhibit the insulin receptor, most frequently occurring in the setting of systemic lupus erythematosus (SLE), and to increase awareness of this rare, life‐threatening ...
S. Amara Ogbonnaya, Sandra G. Williams, Raphael A. Kirou, Marissa Lightbourne, Rebecca J. Brown   +4 more
wiley   +1 more source

Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation. [PDF]

, 1993
Although very similar in sequence, the four subclasses of human immunoglobulin G (IgG) differ markedly in their ability to activate complement. Glu318-Lys320-Lys322 has been identified as a key binding motif for the first component of complement, C1q ...
Morrison, SL, Smith, RI, Tao, MH
core  

Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium [PDF]

, 2008
This study was prompted by the observation that decidual endothelial cells (DECs), unlike endothelial cells (ECs) of blood vessels in normal skin, kidney glomeruli and brain, express surface-bound C1q in physiologic pregnancy. This finding was unexpected,
Agostinis, C., Bossi, F., Bulla, R., De Seta, F., Debeus, A., Ghebrehiwet, B., Radillo, O., Rizzi, L., Tedesco, F., TRIPODO, Claudio   +9 more
core   +1 more source

C1q binding and complement activation by prions and amyloids

Immunobiology, 2007
C1q binds to many non-self and altered-self-materials. These include microorganisms, immune complexes, apoptotic and necrotic cells and their breakdown products, and amyloids. C1q binding to amyloid fibrils found as extracellular deposits in tissues, and subsequent complement activation are involved in the pathology of several amyloid diseases, such as
Sim, Robert B, Kishore, Uday, Villiers, Christian L, Marche, Patrice N, Mitchell, Daniel A   +4 more
openaire   +4 more sources

Clinical, histological, and serological predictors of renal function loss in lupus nephritis.

Arthritis Care &Research, Accepted Article.
Objective Kidney survival is the ultimate goal in lupus nephritis (LN) management, but long‐term predictors remain inadequately studied, requiring long‐term follow‐up. This study aimed to identify baseline and early longitudinal predictors of kidney survival in the Accelerating Medicines Partnership LN longitudinal cohort.
Shangzhu Zhang, Laurence Magder, Daniel Goldman, Judith A. James, Joel M Guthridge, Carla Guthridge, Peter Izmirly, Jill P Buyon, H.Michael Belmont, Richard A. Furie, Noa Schwartz, Chaim Putterman, Jennifer L. Barnas, Jennifer H. Anolik, Sarah French, Maria Dall'era, Avi Z. Rosenberg, Jeffrey Hodgin, Dawit S. Demeke, the Accelerating Medicines Partnership RA/SLE Network, Michelle Petri, Andrea Fava   +21 more
wiley   +1 more source

Emerging Roles of Complement Protein C1q in Neurodegeneration [PDF]

Aging and disease, 2019
The innate immune system is an ancient and primary component system that rapidly reacts to defend the body against external pathogens. C1 is the initial responder of classical pathway of the innate immune system. C1 is comprised of C1q, C1r, and C1s.
openaire   +2 more sources