Results 61 to 70 of about 41,630 (234)

Cerebral complement C1q activation in chronic Toxoplasma infection [PDF]

Brain, Behavior, and Immunity, 2016
Exposure to the neurotropic parasite, Toxoplasma gondii, causes significant brain and behavioral anomalies in humans and other mammals. Understanding the cellular mechanisms of T. gondii-generated brain pathologies would aid the advancement of novel strategies to reduce disease.
Jianchun, Xiao, Ye, Li, Kristin L, Gressitt, Helen, He, Geetha, Kannan, Tracey L, Schultz, Nadezhda, Svezhova, Vern B, Carruthers, Mikhail V, Pletnikov, Robert H, Yolken, Emily G, Severance   +10 more
openaire   +2 more sources

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

C1q nephropathy developing in a case of gastric carcinoma

Saudi Journal of Kidney Diseases and Transplantation, 2019
C1q is a key intermediary in the classical complement pathway. It is known to be activated by several factors including immunoglobulins and charged molecules and is an initiator of the complement cascade.
Kiran Preet Malhotra, Abhilash Chandra, Saumya Shukla, Alka Yadav, Nuzhat Husain   +4 more
doaj   +1 more source

Review of presentations at the 6th European Lupus Meeting 3-5 March 2005. [PDF]

, 2005
The 6th European Lupus Meeting was held at the Royal College of Physicians of London and was attended by 450 delegates. The conference brought together leading speakers from Europe and North America who reviewed current knowledge and exciting new ...
Bowman, SJ, Giles, IP, Ioannou, Y, Rahman, A   +3 more
core   +1 more source

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source

Engineering C1q single-chain globular head variants for enhanced IgM binding

BMC Biology
Background The initiation of the classical complement pathway begins with the binding of the globular head of complement component 1q (C1q) to antigen-bound immunoglobulin M (IgM).
Maria Magdalena John, Anton Barthel, Vanessa Hawlin, Gordana Wozniak-Knopp, Renate Kunert   +4 more
doaj   +1 more source

C1q and the classical complement cascade in geographic atrophy secondary to age-related macular degeneration

International Journal of Retina and Vitreous, 2022
Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a retinal neurodegenerative disorder. Human genetic data support the complement system as a key component of pathogenesis in AMD, which has been further supported by pre ...
Ted Yednock, Donald S. Fong, Eleonora M. Lad   +2 more
doaj   +1 more source

Differential Gene Expression in Liver, Gill, and Olfactory Rosettes of Coho Salmon (Oncorhynchus kisutch) After Acclimation to Salinity. [PDF]

, 2015
Most Pacific salmonids undergo smoltification and transition from freshwater to saltwater, making various adjustments in metabolism, catabolism, osmotic, and ion regulation. The molecular mechanisms underlying this transition are largely unknown.
Bammler, Theo K, Beyer, Richard P, Farin, Federico M, Gallagher, Evan P, Hardiman, Gary, Lavado, Ramon, Maryoung, Lindley A, Schlenk, Daniel, Stapleton, Patricia L   +8 more
core   +1 more source

Interaction between complement subcomponent C1q and bacterial lipopolysaccharides [PDF]

Biochemical Journal, 1989
The heptose-less mutant of Escherichia coli, D31m4, bound complement subcomponent C1q and its collagen-like fragments (C1qCLF) with Ka values of 1.4 x 10(8) and 2.0 x 10(8) M-1 respectively. This binding was suppressed by chemical modification of C1q and C1qCLF using diethyl pyrocarbonate (DEPC).
A, Zohair, S, Chesne, R H, Wade, M G, Colomb   +3 more
openaire   +2 more sources

Complement component C1q is produced by isolated articular chondrocytes [PDF]

Osteoarthritis and Cartilage, 2020
Inflammation and innate immune responses may contribute to development and progression of Osteoarthritis (OA). Chondrocytes are the sole cell type of the articular cartilage and produce extracellular-matrix molecules. How inflammatory mediators reach chondrocytes is incompletely understood.
Lubbers, R., Schaarenburg, R.A. van, Kwekkeboom, J.C., Levarht, E.W.N., Bakker, A.M., Mahdad, R., Monteagudo, S., Cherifi, C., Lories, R.J., Toes, R.E.M., Ioan, A., Trouw, L.A.   +11 more
openaire   +5 more sources