Results 21 to 30 of about 24,672 (204)
Frontiers in Immunology, 2020 To investigate the fine epitope(s) of anti-C1q A08 antibodies and their roles in complement activation in lupus nephritis, C1q A08 and related peptides with various amino acid sequences around A08 were synthesized.
Wen-Jun Wu +23 more
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Frontiers in Immunology, 2019 Pentraxins and complement defense collagens are soluble recognition proteins that sense pathogens and altered-self elements, and trigger immune responses including complement activation.
Isabelle Bally +8 more
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Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells. [PDF]
PLoS ONE, 2009 BACKGROUND:Tissue exudates contain low levels of serum complement proteins, and their regulatory effects on prostate cancer progression are largely unknown.
Qunying Hong +10 more
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Frontiers in Aging Neuroscience, 2022 BackgroundThe immune response and the complement system are associated with cognitive impairment and diabetes mellitus, respectively. Activation of the complement system in these diseases occurs mainly through either the classical pathway or the ...
Zhenxing Li +7 more
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C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions
Frontiers in Immunology, 2017 Complement C1 is the defining component of the classical pathway. Within the C1qC1r2C1s2 complex, C1q functions as a molecular scaffold for C1r2C1s2 and C1q binding to its ligands activates these two serine proteases.
Jinhua Lu, Uday Kishore
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Frontiers in Immunology, 2020 Helminths develop strategies to escape host immune responses that facilitate their survival in the hostile host immune environment. Trichinella spiralis, a tissue-dwelling nematode, has developed a sophisticated strategy to escape complement attack.
Shuai Shao +7 more
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Frontiers in Immunology, 2017 Inflammation is a part of the initial process leading to atherosclerosis and cholesterol crystals (CC), found in atherosclerotic plaques, which are known to induce complement activation.
Katrine Pilely +8 more
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Trichinella spiralis Calreticulin Binds Human Complement C1q As an Immune Evasion Strategy
Frontiers in Immunology, 2017 As a multicellular parasitic nematode, Trichinella spiralis regulates host immune responses by producing a variety of immunomodulatory molecules to escape from host immune attack, but the mechanisms underlying the immune evasion are not well understood ...
Limei Zhao +13 more
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Role of collectins and complement protein C1q in pregnancy and parturition [PDF]
Immunobiology, 2016 Collectins such as surfactant proteins SP-A, SP-D, and mannan-binding lectin (MBL), as well as complement protein C1q are evolutionarily conserved innate immune molecules. They are known to opsonize a range of microbial pathogens (bacteria, fungi, virus, and parasites) and trigger effector clearance mechanisms involving phagocytosis and/or complement ...
Shanmuga Priyaa Madhukaran +5 more
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C1q Regulates Horizontal Cell Neurite Confinement in the Outer Retina
Frontiers in Neural Circuits, 2020 During development, neurons generate excess processes which are then eliminated in concert with circuit maturation. C1q is the initiating protein in the complement cascade and has been implicated in this process, but whether C1q-mediated elimination is ...
Courtney A. Burger +7 more
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