Results 11 to 20 of about 24,672 (204)

Complement, C1q, and C1q-Related Molecules Regulate Macrophage Polarization [PDF]

Frontiers in Immunology, 2014
Complement is a critical system of enzymes, regulatory proteins, and receptors that regulates both innate and adaptive immune responses. Natural mutations in complement molecules highlight their requirement in regulation of a variety of human conditions including infectious disease and autoimmunity.
Bohlson, Suzanne S., O’Conner, Sean D., Hulsebus, Holly Jo, Ho, Minh-Minh, Fraser, Deborah A.   +4 more
openaire   +3 more sources

Trichinella spiralis Paramyosin Binds Human Complement C1q and Inhibits Classical Complement Activation. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Trichinella spiralis expresses paramyosin (Ts-Pmy) as a defense mechanism. Ts-Pmy is a functional protein with binding activity to human complement C8 and C9 and thus plays a role in evading the attack of the host's immune system.
Ran Sun, Xi Zhao, Zixia Wang, Jing Yang, Limei Zhao, Bin Zhan, Xinping Zhu   +6 more
doaj   +1 more source

Epigenetic regulation of complement C1Q gene expression. [PDF]

Front Immunol
Human C1q is a multifaceted complement protein whose functions range from activating the complement classical pathway to immunomodulation and promoting placental development and tumorigenesis. It is encoded by the C1QA, C1QB, and C1QC genes located on chromosome 1.
Pegoraro S, Balduit A, Mangogna A, Kishore U, Ricci G, Agostinis C, Bulla R.   +6 more
europepmc   +5 more sources

Complement in Human Brain Health: Potential of Dietary Food in Relation to Neurodegenerative Diseases

Foods, 2023
The complement pathway is a major component of the innate immune system, which is critical for recognizing and clearing pathogens that rapidly react to defend the body against external pathogens.
Yihang Xing, Dingwen Zhang, Li Fang, Ji Wang, Chunlei Liu, Dan Wu, Xiaoting Liu, Xiyan Wang, Weihong Min   +8 more
doaj   +1 more source

Echinococcus multilocularis Calreticulin Interferes with C1q-Mediated Complement Activation

Tropical Medicine and Infectious Disease, 2023
As a zoonotic disease caused by Echinococcus multilocularis larvae, alveolar echinococcosis (AE) is one of the most severe forms of parasitic infection. Over a long evolutional process E.
Siqi Xian, Lujuan Chen, Yan Yan, Jianfang Chen, Guixia Yu, Yuxiao Shao, Bin Zhan, Yanhai Wang, Limei Zhao   +8 more
doaj   +1 more source

Complement Component C1q and Anti‐C1q Antibodies in Theory and in Clinical Practice [PDF]

Scandinavian Journal of Immunology, 2008
AbstractThe complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti‐C1q) have been found in a number of autoimmune and infectious diseases.
E, Potlukova, P, Kralikova
openaire   +2 more sources

C1q and phagocytosis: the perfect complement to a good meal [PDF]

Journal of Leukocyte Biology, 2012
Abstract Review on the role for C1q in enhancement of phagocytosis, specifically focusing on C1q-mediated clearance of apoptotic cells. Complement component C1q is a member of a family of soluble proteins called defense collagens, which are important in host defense and apoptotic cell clearance.
Manuel D, Galvan, Mallary C, Greenlee-Wacker, Suzanne S, Bohlson   +2 more
openaire   +2 more sources

MafB is a critical regulator of complement component C1q [PDF]

Nature Communications, 2017
AbstractThe transcription factor MafB is expressed by monocytes and macrophages. Efferocytosis (apoptotic cell uptake) by macrophages is important for inhibiting the development of autoimmune diseases, and is greatly reduced inMafb-deficient macrophages.
Mai Thi Nhu Tran, Michito Hamada, Hyojung Jeon, Risako Shiraishi, Keigo Asano, Motochika Hattori, Megumi Nakamura, Yuki Imamura, Yuki Tsunakawa, Risa Fujii, Toshiaki Usui, Kaushalya Kulathunga, Christina-Sylvia Andrea, Ryusuke Koshida, Risa Kamei, Yurina Matsunaga, Makoto Kobayashi, Hisashi Oishi, Takashi Kudo, Satoru Takahashi   +19 more
openaire   +3 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Complement in Renal Disease as a Potential Contributor to Arterial Hypertension

Kidney & Blood Pressure Research, 2021
Objective: Complement deposition is prevalent in kidney biopsies of patients with arterial hypertension and hypertensive nephropathy, but an association of hypertension and complement deposition or involvement of complement in the pathogenesis of ...
Lisa-Maren Fischer, Laura A. Fichte, Maike Büttner-Herold, Fulvia Ferrazzi, Kerstin Amann, Kerstin Benz, Christoph Daniel   +6 more
doaj   +1 more source