Results 11 to 20 of about 41,630 (234)
Prognostic Implications of the Complement Protein C1q in Gliomas [PDF]
Frontiers in Immunology, 2019 The contribution of the complement system in the pathophysiology of brain cancers has been recently considered in light of its well-known involvement in carcinogenesis.
Alessandro Mangogna +2 more
exaly +8 more sources
MafB is a critical regulator of complement component C1q [PDF]
Nature Communications, 2017 The transcription factor MafB is expressed by monocytes and macrophages. Efferocytosis (apoptotic cell uptake) by macrophages is important for inhibiting the development of autoimmune diseases, and is greatly reduced in Mafb-deficient macrophages.
Andrea Christina-Sylvia +24 more
core +5 more sources
Epigenetic regulation of complement C1Q gene expression. [PDF]
Front ImmunolHuman C1q is a multifaceted complement protein whose functions range from activating the complement classical pathway to immunomodulation and promoting placental development and tumorigenesis. It is encoded by the C1QA, C1QB, and C1QC genes located on chromosome 1.
Pegoraro S +6 more
europepmc +5 more sources
Complement, C1q, and C1q-Related Molecules Regulate Macrophage Polarization [PDF]
Frontiers in Immunology, 2014 Complement is a critical system of enzymes, regulatory proteins, and receptors that regulates both innate and adaptive immune responses. Natural mutations in complement molecules highlight their requirement in regulation of a variety of human conditions including infectious disease and autoimmunity.
Bohlson, Suzanne S. +4 more
openaire +3 more sources
Trichinella spiralis Paramyosin Binds Human Complement C1q and Inhibits Classical Complement Activation. [PDF]
PLoS Neglected Tropical Diseases, 2015 BACKGROUND:Trichinella spiralis expresses paramyosin (Ts-Pmy) as a defense mechanism. Ts-Pmy is a functional protein with binding activity to human complement C8 and C9 and thus plays a role in evading the attack of the host's immune system.
Ran Sun +6 more
doaj +1 more source
C1q as a target molecule to treat human disease: What do mouse studies teach us?
Frontiers in Immunology, 2022 The complement system is a field of growing interest for pharmacological intervention. Complement protein C1q, the pattern recognition molecule at the start of the classical pathway of the complement cascade, is a versatile molecule with additional non ...
Kristina Schulz +3 more
doaj +1 more source
Foods, 2023 The complement pathway is a major component of the innate immune system, which is critical for recognizing and clearing pathogens that rapidly react to defend the body against external pathogens.
Yihang Xing +8 more
doaj +1 more source
Echinococcus multilocularis Calreticulin Interferes with C1q-Mediated Complement Activation
Tropical Medicine and Infectious Disease, 2023 As a zoonotic disease caused by Echinococcus multilocularis larvae, alveolar echinococcosis (AE) is one of the most severe forms of parasitic infection. Over a long evolutional process E.
Siqi Xian +8 more
doaj +1 more source
Complement Component C1q and Anti‐C1q Antibodies in Theory and in Clinical Practice [PDF]
Scandinavian Journal of Immunology, 2008 AbstractThe complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti‐C1q) have been found in a number of autoimmune and infectious diseases.
E, Potlukova, P, Kralikova
openaire +2 more sources
C1q and phagocytosis: the perfect complement to a good meal [PDF]
Journal of Leukocyte Biology, 2012 Abstract Review on the role for C1q in enhancement of phagocytosis, specifically focusing on C1q-mediated clearance of apoptotic cells. Complement component C1q is a member of a family of soluble proteins called defense collagens, which are important in host defense and apoptotic cell clearance.
Manuel D, Galvan +2 more
openaire +2 more sources