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The immunoglobulin G binding site of complement protein C1q.

, 1990
Bruce D. Wines
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Binding of complement component C1q by spectrin

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1986
125I-labelled human C1q was found to bind to human spectrin. Scatchard plots for the binding process were non-linear, indicating the possible presence of multiple classes of binding sites for C1q on spectrin. The binding was ionic-strength-dependent; the extent of binding decreased with increasing ionic strength.
A, Comis, S B, Easterbrook-Smith
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Clinical implications and mechanism of complement C1q in polymyositis

Applied Biochemistry and Biotechnology, 2023
Polymyositis (PM) is the most common autoimmune disease in neurology and among muscle disorders; it is of great significance to thoroughly understand the mechanism of PM to find new diagnosis and treatment methods. This research intends to elucidate the clinical implications and mechanisms of complement C1q in polymyositis (PM).
Di Wu, Yan Cui, Yujia Cao, Yanjuan Wang, Jinhua Zhang, Yijing Guo, Baoyu Yuan   +6 more
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Complement and C1q Binding Substances in Otitis Media

Annals of Otology, Rhinology & Laryngology, 1980
Complement activation, as shown by increased amounts of complexes composed of Clr-Cls-Cl IA, and abnormal complexes of Clr-Cls were demonstrated in serum from patients with acute pneumococcal and chronic otitis media, serous or mucoid respectively. C1q binding substances were shown in middle ear effusions and in sera from patients with chronic serous ...
K, Prellner, N I, Nilsson, U, Johnson, A B, Laurell   +3 more
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Detection of complement C1q receptors on human spermatozoa

Journal of Reproductive Immunology, 1998
Clq, the first component of the classical complement pathway, is known to play roles in promoting phagocytic events, in addition to its role in activation of complement. Although the molecular events in fertilization leading to the entrance of the spermatozoan into the egg are not well understood, ultrastructural observations suggest that the process ...
R, Bronson, S, Bronson, L, Oula, W, Zhang, B, Ghebrehiwet   +4 more
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Complement C1q Does Not Bind Monomeric β-Amyloid

Experimental Neurology, 1994
The tendency of both labeled and unlabeled beta-amyloid to bind in solution to C1q, the recognition species in the complement cascade, was examined using both hydrodynamic and spectroscopic methods. Potential binding interactions were evaluated using a purified synthetic beta-amyloid 1-40 sequence, alone, and selectively labeled at the amino terminus ...
S W, Snyder, G T, Wang, L, Barrett, U S, Ladror, D, Casuto, C M, Lee, G A, Krafft, R B, Holzman, T F, Holzman   +8 more
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Roles of Complement C1q in Pneumococcus-Host Interactions

Critical Reviews in Immunology, 2015
The fight between a human host and a bacterial pathogen is highly complicated; each party tries to outshine the other in the race for survival. In humans, the innate immune system--in particular the complement system--functions as the first line of defence against invading pathogens.
Vaibhav, Agarwal, Anna M, Blom
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Complement C1q subunit molecules from Xenopus laevis possess conserved function in C1q-immunoglobulin interaction

Developmental & Comparative Immunology, 2020
Complement component 1q (C1q), together with C1r and C1s to form C1, recognize and bind immune complex to initiate the classical complement pathway. In this study, C1q subunit molecules (XlC1qA, XlC1qB, XlC1qC) were cloned and analyzed from Xenopus laevis (X. laevis).
Fangfang, Yan, Enxu, Zhou, Shuo, Liu, Along, Gao, Linghe, Kong, Bingxi, Li, Xiao, Tu, Zheng, Guo, Jinfeng, Mo, Meng, Chen, Jianmin, Ye   +10 more
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Adsorption of Complement Proteins C3 and C1q

Journal of Colloid and Interface Science, 1996
Abstract Surface localization plays a key but ill defined role in activation of the serum complement system with or without related “opsonic” proteins. The adsorption of key complement components C3 and C1q and various opsonins, e.g., IgG, were therefore studied on different surfaces usingin situellipsometry.
Martin Malmsten, Bo Lassen, James M. Van Alstine, Ulf R. Nilsson   +3 more
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