Results 21 to 30 of about 23,738 (171)
Frontiers in Immunology, 2020 To investigate the fine epitope(s) of anti-C1q A08 antibodies and their roles in complement activation in lupus nephritis, C1q A08 and related peptides with various amino acid sequences around A08 were synthesized.
Wen-Jun Wu +23 more
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Cerebral complement C1q activation in chronic Toxoplasma infection [PDF]
Brain, Behavior, and Immunity, 2016 Exposure to the neurotropic parasite, Toxoplasma gondii, causes significant brain and behavioral anomalies in humans and other mammals. Understanding the cellular mechanisms of T. gondii-generated brain pathologies would aid the advancement of novel strategies to reduce disease.
Jianchun, Xiao +10 more
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Frontiers in Immunology, 2019 Pentraxins and complement defense collagens are soluble recognition proteins that sense pathogens and altered-self elements, and trigger immune responses including complement activation.
Isabelle Bally +8 more
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Frontiers in Aging Neuroscience, 2022 BackgroundThe immune response and the complement system are associated with cognitive impairment and diabetes mellitus, respectively. Activation of the complement system in these diseases occurs mainly through either the classical pathway or the ...
Zhenxing Li +7 more
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Interaction between complement subcomponent C1q and bacterial lipopolysaccharides [PDF]
Biochemical Journal, 1989 The heptose-less mutant of Escherichia coli, D31m4, bound complement subcomponent C1q and its collagen-like fragments (C1qCLF) with Ka values of 1.4 x 10(8) and 2.0 x 10(8) M-1 respectively. This binding was suppressed by chemical modification of C1q and C1qCLF using diethyl pyrocarbonate (DEPC).
A, Zohair +3 more
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Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells. [PDF]
PLoS ONE, 2009 BACKGROUND:Tissue exudates contain low levels of serum complement proteins, and their regulatory effects on prostate cancer progression are largely unknown.
Qunying Hong +10 more
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C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions
Frontiers in Immunology, 2017 Complement C1 is the defining component of the classical pathway. Within the C1qC1r2C1s2 complex, C1q functions as a molecular scaffold for C1r2C1s2 and C1q binding to its ligands activates these two serine proteases.
Jinhua Lu, Uday Kishore
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Complement C1q expression in Erythema nodosum leprosum
PLOS Neglected Tropical Diseases, 2018 Complement C1q is a soluble protein capable of initiating components of the classical pathway in host defence system. In earlier qualitative studies, C1q has been implicated in the pathogenesis of Erythema Nodosum Leprosum (ENL). However, little is known about the role of this complement in ENL reaction.
Edessa Negera +5 more
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Complement Component C1q and Anti‐C1q Antibodies in Theory and in Clinical Practice [PDF]
Scandinavian Journal of Immunology, 2008 AbstractThe complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti‐C1q) have been found in a number of autoimmune and infectious diseases.
E, Potlukova, P, Kralikova
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Functional recombinant human complement C1q with different affinity tags [PDF]
Journal of Immunological Methods, 2021 Complement C1q is a multifunctional protein able to sense pathogens and immune molecules such as immunoglobulins and pentraxins, and to trigger the classical complement pathway through activation of its two associated proteases, C1r and C1s. C1q is a multimeric protein composed of three homologous yet distinct polypeptide chains A, B, and C, each ...
Bally, Isabelle +5 more
openaire +4 more sources