MafB is a critical regulator of complement component C1q [PDF]
Nature Communications, 2017 The transcription factor MafB is expressed by monocytes and macrophages. Efferocytosis (apoptotic cell uptake) by macrophages is important for inhibiting the development of autoimmune diseases, and is greatly reduced in Mafb-deficient macrophages.
Andrea Christina-Sylvia +24 more
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Emerging and novel functions of complement protein C1q [PDF]
Frontiers in Immunology, 2015 Complement protein C1q, the recognition subcomponent of the classical pathway, performs a diverse range of complement and non-complement functions. It can bind various ligands derived from self, non-self and altered-self and modulate the functions of ...
Lubna eKouser +6 more
doaj +6 more sources
Autoantibodies against complement component C1q in systemic lupus erythematosus
Clinical & Translational Immunology, 2021 Systemic lupus erythematosus (SLE) is the archetype of a systemic autoimmune disease, but the multifaceted pathogenic mechanisms leading to inflammation and organ damage are not fully understood.
Marten Trendelenburg
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Increased complement C1q level marks active disease in human tuberculosis. [PDF]
PLoS ONE, 2014 BackgroundComplement functions as an important host defense system and complement C5 and C7 have been implicated in immunopathology of tuberculosis. However, little is known about the role of other complement components in tuberculosis.MethodsComplement ...
Yi Cai +11 more
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Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex [PDF]
Journal of Neuroinflammation, 2020 Cognitive impairment in schizophrenia, aging, and Alzheimer’s disease is associated with spine and synapse loss from the dorsolateral prefrontal cortex (dlPFC) layer III.
Dibyadeep Datta +7 more
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Emerging Roles of Complement Protein C1q in Neurodegeneration [PDF]
Aging and disease, 2019 The innate immune system is an ancient and primary component system that rapidly reacts to defend the body against external pathogens. C1 is the initial responder of classical pathway of the innate immune system.
Kyoungjoo Cho
semanticscholar +3 more sources
Frontiers in Immunology, 2020 The classical pathway of complement is important for protection against pathogens and in maintaining tissue homeostasis, but excessive or aberrant activation is directly linked to numerous pathologies.
Nick S. Laursen +7 more
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Fibronectin binds to the C1q component of complement. [PDF]
Proceedings of the National Academy of Sciences, 1982 Fibronectin immobilized to plastic tubes binds soluble C1q with a Kd of 82 +/- 2.6 nM. The binding of fibronectin to C1q is relatively insensitive to pH but is sensitive to ionic conditions. C1q covalently bound to Sepharose selectively binds cellular fibronectin produced by a hamster fibroblast cell line.
David H. Bing +4 more
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Complement-Coagulation Cross-talk: Factor H-mediated regulation of the Complement Classical Pathway activation by fibrin clots [PDF]
Frontiers in ImmunologyThe classical pathway of the complement system is activated by the binding of C1q in the C1 complex to the target activator, including immune complexes. Factor H is regarded as the key downregulatory protein of the complement alternative pathway. However,
Yu-Hoi Kang +7 more
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Mapping of the complement C1q binding site on Trichinella spiralis paramyosin [PDF]
Parasites & Vectors, 2018 Background Trichinella spiralis is a tissue-dwelling parasite has developed the ability to evade the host immune attack to establish parasitism in a host.
Zixia Wang +5 more
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