Mapping of the complement C1q binding site on Trichinella spiralis paramyosin [PDF]
Parasites & Vectors, 2018 Background Trichinella spiralis is a tissue-dwelling parasite has developed the ability to evade the host immune attack to establish parasitism in a host.
Zixia Wang +5 more
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The Fc fragment of IgMs binds C1q to activate the first step of the classical complement pathway, while inhibiting complement-dependent cytotoxicity [PDF]
The FEBS Journal, EarlyView.Multimeric IgM‐fragment crystallizable region (Fc) fragments retain the ability to bind C1q and initiate the classical complement pathway, leading to C4 activation and deposition in vitro. However, the Fc cores can also inhibit complement‐dependent cytotoxicity by competing with surface‐bound antibodies for C1q engagement.
Andre J. Pinto +9 more
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Molecular Basis of Complement C1q Collagen-Like Region Interaction with the Immunoglobulin-Like Receptor LAIR-1. [PDF]
Int J Mol Sci, 2021 Fouët G +6 more
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Activation of complement C1q and C3 in glomeruli might accelerate the progression of diabetic nephropathy: Evidence from transcriptomic data and renal histopathology. [PDF]
J Diabetes Investig, 2022 Jiao Y +6 more
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Functional recombinant human complement C1q with different affinity tags [PDF]
Journal of Immunological Methods, 2021 Complement C1q is a multifunctional protein able to sense pathogens and immune molecules such as immunoglobulins and pentraxins, and to trigger the classical complement pathway through activation of its two associated proteases, C1r and C1s. C1q is a multimeric protein composed of three homologous yet distinct polypeptide chains A, B, and C, each ...
Isabelle Bally +5 more
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Complement Activation And C1q Binding Activity In Haemodialysis [PDF]
Thrombosis and Haemostasis, 1981 It has been proposed that hypoxia occurring during Haemodialysis (HD) is related to complement activation by the dialysis membrane. Consequent leucocyte aggregation may then lead to pulmonary micro-embolisation. We set out to assess complement activation during HD using a new, sensitive, assay for activation fragment C3d.Twenty patients, established on
N J Dodd +4 more
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C1q as a target molecule to treat human disease: What do mouse studies teach us?
Frontiers in Immunology, 2022 The complement system is a field of growing interest for pharmacological intervention. Complement protein C1q, the pattern recognition molecule at the start of the classical pathway of the complement cascade, is a versatile molecule with additional non ...
Kristina Schulz +3 more
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Foods, 2023 The complement pathway is a major component of the innate immune system, which is critical for recognizing and clearing pathogens that rapidly react to defend the body against external pathogens.
Yihang Xing +8 more
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Complement, C1q, and C1q-Related Molecules Regulate Macrophage Polarization [PDF]
Frontiers in Immunology, 2014 Complement is a critical system of enzymes, regulatory proteins, and receptors that regulates both innate and adaptive immune responses. Natural mutations in complement molecules highlight their requirement in regulation of a variety of human conditions including infectious disease and autoimmunity.
Bohlson, Suzanne S. +4 more
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Autoantibodies against Complement C1q Specifically Target C1q Bound on Early Apoptotic Cells [PDF]
The Journal of Immunology, 2009 AbstractAutoantibodies against complement C1q (anti-C1q) are frequently found in patients with systemic lupus erythematosus (SLE). They strongly correlate with the occurrence of severe lupus nephritis, suggesting a pathogenic role in SLE. Because anti-C1q are known to recognize a neoepitope on bound C1q, but not on fluid-phase C1q, the aim of this ...
Bigler, Cornelia +4 more
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