Results 51 to 60 of about 40,238 (270)
Clinical risk stratification of paediatric renal transplant recipients using C1q and C3d fixing of de novo donor-specific antibodies [PDF]
, 2017 Introduction: We have previously shown that children who developed de novo donor-specific human leukocyte antigen (HLA) antibodies (DSA) had greater decline in allograft function.
A Fearn +35 more
core +3 more sources
Frontiers in Immunology, 2018 IgG antibodies (Abs) mediate their effector functions through the interaction with Fcγ receptors (FcγRs) and the complement factors. The main IgG-mediated complement activation pathway is induced through the binding of complement C1q to IgG Abs.
Gina-Maria Lilienthal +7 more
doaj +1 more source
Clinical impact of complement (C1q, C3d) binding De Novo donor-specific HLA antibody in kidney transplant recipients. [PDF]
PLoS ONE, 2018 INTRODUCTION:Complement binding activity of donor-specific HLA antibodies (DSA) has been suggested as a new tool to stratify immunologic risk in kidney transplantation (KT).
Hyeyoung Lee +7 more
doaj +1 more source
Review of presentations at the 6th European Lupus Meeting 3-5 March 2005. [PDF]
, 2005 The 6th European Lupus Meeting was held at the Royal College of Physicians of London and was attended by 450 delegates. The conference brought together leading speakers from Europe and North America who reviewed current knowledge and exciting new ...
Bowman, SJ +3 more
core +1 more source
Complement is dispensable for neurodegeneration in Niemann-Pick disease type C
Journal of Neuroinflammation, 2012 Background The immune system has been implicated in neurodegeneration during development and disease. In various studies, the absence of complement (that is, C1q deficiency) impeded the elimination of apoptotic neurons, allowing survival.
Lopez Manuel E +2 more
doaj +1 more source
Complement component C1q is produced by isolated articular chondrocytes [PDF]
Osteoarthritis and Cartilage, 2019 Inflammation and innate immune responses may contribute to development and progression of Osteoarthritis (OA). Chondrocytes are the sole cell type of the articular cartilage and produce extracellular-matrix molecules. How inflammatory mediators reach chondrocytes is incompletely understood.
Rosalie Lubbers +11 more
openalex +5 more sources
The Solution Structures of Two Human IgG1 Antibodies Show Conformational Stability and Accommodate Their C1q and FcγR Ligands. [PDF]
, 2015 The human IgG1 antibody subclass shows distinct properties compared with the IgG2, IgG3, and IgG4 subclasses and is the most exploited subclass in therapeutic antibodies. It is the most abundant subclass, has a half-life as long as that of IgG2 and IgG4,
Abe +79 more
core +1 more source
Effect of aging on bone metabolism: the involvement of complement C1q
Journal of Prosthodontic Research, 2021 Purpose Impairment of normal bone remodeling affects the successful osseointegration of dental implants. Recently, it has been reported that complement C1q level increases with age and delays wound healing by modulating Wnt signaling. As Wnt signaling is known to play an essential role in bone remodeling, we hypothesized that aging-dependent increases ...
Hiroshi Takeuchi +6 more
openaire +4 more sources
LifeThe interaction between IgM and C1q represents the first step of the classical pathway of the complement system in higher vertebrates. To identify the significance of particular IgM/C1q interactions, recombinant IgMs were used in both hexameric and ...
Maria Magdalena John +4 more
doaj +1 more source
Heme Interacts with C1q and Inhibits the Classical Complement Pathway [PDF]
Journal of Biological Chemistry, 2011 C1q is the recognition subunit of the first component of the classical complement pathway. It participates in clearance of immune complexes and apoptotic cells as well as in defense against pathogens. Inappropriate activation of the complement contributes to cellular and tissue damage in different pathologies, urging the need for the development of ...
Boris P. Atanasov +15 more
openaire +4 more sources