Results 51 to 60 of about 42,931 (245)
Frontiers in Immunology, 2017 Inflammation is a part of the initial process leading to atherosclerosis and cholesterol crystals (CC), found in atherosclerotic plaques, which are known to induce complement activation.
Katrine Pilely +8 more
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Trichinella spiralis Calreticulin Binds Human Complement C1q As an Immune Evasion Strategy
Frontiers in Immunology, 2017 As a multicellular parasitic nematode, Trichinella spiralis regulates host immune responses by producing a variety of immunomodulatory molecules to escape from host immune attack, but the mechanisms underlying the immune evasion are not well understood ...
Limei Zhao +13 more
doaj +1 more source
C1q Regulates Horizontal Cell Neurite Confinement in the Outer Retina
Frontiers in Neural Circuits, 2020 During development, neurons generate excess processes which are then eliminated in concert with circuit maturation. C1q is the initiating protein in the complement cascade and has been implicated in this process, but whether C1q-mediated elimination is ...
Courtney A. Burger +7 more
doaj +1 more source
Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]
, 2015 Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Hristova, M, Rocha-Ferreira, E
core +1 more source
Complement Activation-Independent Attenuation of SARS-CoV-2 Infection by C1q and C4b-Binding Protein
Viruses, 2023 The complement system is a key component of the innate immune response to viruses and proinflammatory events. Exaggerated complement activation has been attributed to the induction of a cytokine storm in severe SARS-CoV-2 infection.
Nazar Beirag +9 more
doaj +1 more source
Frontiers in Immunology, 2018 IgG antibodies (Abs) mediate their effector functions through the interaction with Fcγ receptors (FcγRs) and the complement factors. The main IgG-mediated complement activation pathway is induced through the binding of complement C1q to IgG Abs.
Gina-Maria Lilienthal +7 more
doaj +1 more source
Review of presentations at the 6th European Lupus Meeting 3-5 March 2005. [PDF]
, 2005 The 6th European Lupus Meeting was held at the Royal College of Physicians of London and was attended by 450 delegates. The conference brought together leading speakers from Europe and North America who reviewed current knowledge and exciting new ...
Bowman, SJ +3 more
core +1 more source
Clinical impact of complement (C1q, C3d) binding De Novo donor-specific HLA antibody in kidney transplant recipients. [PDF]
PLoS ONE, 2018 INTRODUCTION:Complement binding activity of donor-specific HLA antibodies (DSA) has been suggested as a new tool to stratify immunologic risk in kidney transplantation (KT).
Hyeyoung Lee +7 more
doaj +1 more source
Angewandte Chemie, EarlyView.A streamlined platform for glycosite‐specific antibody conjugation is enabled by LacNAc‐derived cyclic acetal donors, which can be prepared in only two steps and used directly in single‐enzyme Endo S2‐mediated transglycosylation. The platform supports the broad construction of homogeneous gsADCs and gsDACs, with donor 7 producing glycoengineered ...
Deqin Cai +13 more
wiley +2 more sources
LifeThe interaction between IgM and C1q represents the first step of the classical pathway of the complement system in higher vertebrates. To identify the significance of particular IgM/C1q interactions, recombinant IgMs were used in both hexameric and ...
Maria Magdalena John +4 more
doaj +1 more source