Results 51 to 60 of about 41,476 (260)

Review of presentations at the 6th European Lupus Meeting 3-5 March 2005. [PDF]

, 2005
The 6th European Lupus Meeting was held at the Royal College of Physicians of London and was attended by 450 delegates. The conference brought together leading speakers from Europe and North America who reviewed current knowledge and exciting new ...
Bowman, SJ, Giles, IP, Ioannou, Y, Rahman, A   +3 more
core   +1 more source

Complement is dispensable for neurodegeneration in Niemann-Pick disease type C

Journal of Neuroinflammation, 2012
Background The immune system has been implicated in neurodegeneration during development and disease. In various studies, the absence of complement (that is, C1q deficiency) impeded the elimination of apoptotic neurons, allowing survival.
Lopez Manuel E, Klein Andres D, Scott Matthew P   +2 more
doaj   +1 more source

Complement component C1q is produced by isolated articular chondrocytes [PDF]

Osteoarthritis and Cartilage, 2019
Inflammation and innate immune responses may contribute to development and progression of Osteoarthritis (OA). Chondrocytes are the sole cell type of the articular cartilage and produce extracellular-matrix molecules. How inflammatory mediators reach chondrocytes is incompletely understood.
Rosalie Lubbers, Rosanne A. van Schaarenburg, Joanneke C. Kwekkeboom, E. W. Nivine Levarht, Aleida M. Bakker, Rachid Mahdad, Silvia Monteagudo, C. Cherifi, Rik Lories, René E. M. Toes, A. Ioan-Facsinay, Leendert A. Trouw   +11 more
openalex   +6 more sources

Interaction Studies of Hexameric and Pentameric IgMs with Serum-Derived C1q and Recombinant C1q Mimetics

Life
The interaction between IgM and C1q represents the first step of the classical pathway of the complement system in higher vertebrates. To identify the significance of particular IgM/C1q interactions, recombinant IgMs were used in both hexameric and ...
Maria Magdalena John, Monika Hunjadi, Vanessa Hawlin, Jean-Baptiste Reiser, Renate Kunert   +4 more
doaj   +1 more source

The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA

Cell Reports, 2019
Summary: Movement is an essential behavior requiring the assembly and refinement of spinal motor circuits. However, the mechanisms responsible for circuit refinement and synapse maintenance are poorly understood.
Aleksandra Vukojicic, Nicolas Delestrée, Emily V. Fletcher, John G. Pagiazitis, Sethu Sankaranarayanan, Ted A. Yednock, Ben A. Barres, George Z. Mentis   +7 more
doaj   +1 more source

Heme Interacts with C1q and Inhibits the Classical Complement Pathway [PDF]

Journal of Biological Chemistry, 2011
C1q is the recognition subunit of the first component of the classical complement pathway. It participates in clearance of immune complexes and apoptotic cells as well as in defense against pathogens. Inappropriate activation of the complement contributes to cellular and tissue damage in different pathologies, urging the need for the development of ...
Boris P. Atanasov, Véronique Frémeaux-Bacchi, Jordan D. Dimitrov, Jordan D. Dimitrov, Jordan D. Dimitrov, Lubka T. Roumenina, Lubka T. Roumenina, Lubka T. Roumenina, Krastio T. Popov, Maria Radanova, Sébastien Lacroix-Desmazes, Sébastien Lacroix-Desmazes, Sébastien Lacroix-Desmazes, Srini V. Kaveri, Srini V. Kaveri, Srini V. Kaveri   +15 more
openaire   +4 more sources

Effect of aging on bone metabolism: the involvement of complement C1q

Journal of Prosthodontic Research, 2021
Purpose Impairment of normal bone remodeling affects the successful osseointegration of dental implants. Recently, it has been reported that complement C1q level increases with age and delays wound healing by modulating Wnt signaling. As Wnt signaling is known to play an essential role in bone remodeling, we hypothesized that aging-dependent increases ...
Hiroshi Takeuchi, Fumiko Aonuma, Shintaro Tsuka, Tomoko Ohsumi, Sen Higashi, Ryuji Hosokawa, Chihiro Masaki   +6 more
openaire   +4 more sources

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]

, 2012
BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Carl Cotman, Erik Hrabovszky, Imre Kalló, István Likó, Miklós Sárvári, Nicole Berchtold, Norbert Solymosi, Sárvári, Miklós, Zsolt Liposits   +8 more
core   +2 more sources

Role of Complement Component C1q in the Onset of Preeclampsia in Mice [PDF]

Hypertension, 2011
Preeclampsia (PE) is a life-threatening, pregnancy-induced disease and a leading cause of maternal and fetal morbidity and mortality. Despite considerable research, the causes of PE remain unclear, and there is no effective treatment.
Singh, Jameel, Ahmed, Abdulwahab, Girardi, Guillermina   +2 more
openaire   +4 more sources

Soluble gC1qR is an autocrine signal that induces B1R expression on endothelial cells [PDF]

, 2013
Bradykinin (BK) is one of the most potent vasodilator agonists known and belongs to the kinin family of proinflammatory peptides. BK induces its activity via two G protein-coupled receptors: BK receptor 1 (B1R) and BK receptor 2.
David, H, Galanakis, DK, Ghebrehiwet, B, Hosszu, KH, Ji, Y, Kew, RR, Kishore, U, Pednekar, L, Peerschke, EIB, Ramadass, M, Valentino, A   +10 more
core   +2 more sources