Results 51 to 60 of about 729,206 (315)

Alcohol Increases Exosome Release from Microglia to Promote Complement C1q-Induced Cellular Death of Proopiomelanocortin Neurons in the Hypothalamus in a Rat Model of Fetal Alcohol Spectrum Disorders

Journal of Neuroscience, 2020
Microglia, a type of CNS immune cell, have been shown to contribute to ethanol-activated neuronal death of the stress regulatory proopiomelanocortin (POMC) neuron-producing β-endorphin peptides in the hypothalamus in a postnatal rat model of fetal ...
S. Mukherjee, Miguel A. Cabrera, N. Boyadjieva, Grégory Berger, B. Rousseau, D. Sarkar   +5 more
semanticscholar   +1 more source

The utility of molecularly imprinted polymers for mass spectrometric protein and proteomics analysis

PROTEOMICS, Volume 22, Issue 23-24, December 2022., 2022
Abstract Selective and efficient sample clean‐up is important in mass spectrometric protein‐ and proteomics analyses from biological matrices. Molecularly imprinted polymers (MIPs), polymers prepared to have tailor‐made cavities for capture of target analytes may by such represent an interesting alternative for selective clean‐up.
Trine Grønhaug Halvorsen, Léon Reubsaet   +1 more
wiley   +1 more source

Interaction of C1q With Pentraxin 3 and IgM Revisited: Mutational Studies With Recombinant C1q Variants

Frontiers in Immunology, 2019
Pentraxins and complement defense collagens are soluble recognition proteins that sense pathogens and altered-self elements, and trigger immune responses including complement activation.
Isabelle Bally, Antonio Inforzato, Antonio Inforzato, Fabien Dalonneau, Matteo Stravalaci, Matteo Stravalaci, Barbara Bottazzi, Christine Gaboriaud, Nicole M. Thielens   +8 more
doaj   +1 more source

Human C1q Induces Apoptosis in an Ovarian Cancer Cell Line via Tumor Necrosis Factor [PDF]

, 2016
Copyright: © 2016 Kaur, Sultan, Murugaiah, Pathan, Alhamlan, Karteris and Kishore. Human C1q is the first recognition subcomponent of the complement classical pathway that plays a vital role in the clearance of immune complexes, pathogens and apoptotic ...
Alhamlan, F, Karteris, E, Kaur, A, Kishore, U, Murugaiah, V, Pathan, AA, Sultan, SHA   +6 more
core   +1 more source

Tumor Cells Hijack Macrophage-Produced Complement C1q to Promote Tumor Growth

Cancer immunology research, 2019
The density of C1q-producing TAMs and C4d deposits, hallmarks of complement activation, are negative prognostic factors in human clear-cell renal cell carcinoma.
L. Roumenina, Marie V. Daugan, Rémi Noé, F. Petitprez, Y. Vano, R. Sanchez-Salas, E. Becht, J. Meilleroux, Bénédicte Le Clec'h, Nicolas A. Giraldo, N. Merle, Cheng-Ming Sun, V. Verkarre, P. Validire, J. Selves, L. Lacroix, O. Delfour, I. Vandenberghe, C. Thuilliez, S. Keddani, Imene B. Sakhi, E. Barret, P. Ferré, N. Corvaïa, A. Passioukov, E. Chetaille, M. Botto, A. de Reyniès, S. Oudard, A. Méjean, X. Cathelineau, C. Sautès-Fridman, W. Fridman   +32 more
semanticscholar   +1 more source

Role of collectins and complement protein C1q in pregnancy and parturition [PDF]

Immunobiology, 2016
Collectins such as surfactant proteins SP-A, SP-D, and mannan-binding lectin (MBL), as well as complement protein C1q are evolutionarily conserved innate immune molecules. They are known to opsonize a range of microbial pathogens (bacteria, fungi, virus, and parasites) and trigger effector clearance mechanisms involving phagocytosis and/or complement ...
Shanmuga Priyaa Madhukaran, Fatimah S. Alhamlan, Kavita Kale, Manu Vatish, Taruna Madan, Uday Kishore   +5 more
openaire   +5 more sources

C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy [PDF]

, 2016
Introduction Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options.
Barrie, Jennifer A., Cunningham, Madeleine E., Fewou, Simon N., Furukawa, Koichi, McGonigal, Rhona, Sankaranarayanan, Sethu, Willison, Hugh J., Yao, Denggao, Yednock, Ted A.   +8 more
core   +2 more sources

C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions

Frontiers in Immunology, 2017
Complement C1 is the defining component of the classical pathway. Within the C1qC1r2C1s2 complex, C1q functions as a molecular scaffold for C1r2C1s2 and C1q binding to its ligands activates these two serine proteases.
Jinhua Lu, Uday Kishore
doaj   +1 more source

Engineering novel complement activity into a pulmonary surfactant protein [PDF]

, 2010
Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Anthony H. Keeble, Brodsky-Doyle, Chen, Chen, Christopher Furze, Daniel A. Mitchell, Doliana, Emsley, Fan, Feinberg, Girija, Haurum, Heise, Hohenester, Hoppe, Jensenius, Julia Toth, Kaufman, Kurata, Phillips, Porter, Reid, Reid, Reid, Russell Wallis, Scherer, Shoulders, Sim, Strang, Teillet, Uemura, Umakhanth Venkatraman Girija, Wallis, Wallis, Wallis, Wallis, Wallis, Wallis, Wilhelm J. Schwaeble   +38 more
core   +2 more sources

Commensurability classes of 2-bridge knot complements [PDF]

Algebr. Geom. Topol. 8 (2008) 1031-1057, 2006
We show that a hyperbolic 2-bridge knot complement is the unique knot complement in its commensurability class. We also discuss constructions of commensurable hyperbolic knot complements and put forth a conjecture on the number of hyperbolic knot complements in a commensurability class.
arxiv   +1 more source