Results 61 to 70 of about 729,206 (315)

Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance [PDF]

, 2010
Complement activation is known to have deleterious effects on organ transplantation. On the other hand, the complement system is also known to have an important role in regulating immune responses.
Addey, C, Baruah, P, Botto, M, Chai, JG, Coe, D, Cook, T, Derbyshire, K, Dumitriu, IE, Dyson, J, Scott, D, Simpson, E   +10 more
core   +2 more sources

C1q binding and complement activation by prions and amyloids

Immunobiology, 2007
C1q binds to many non-self and altered-self-materials. These include microorganisms, immune complexes, apoptotic and necrotic cells and their breakdown products, and amyloids. C1q binding to amyloid fibrils found as extracellular deposits in tissues, and subsequent complement activation are involved in the pathology of several amyloid diseases, such as
Daniel A. Mitchell, Daniel A. Mitchell, Christian L. Villiers, Uday Kishore, Uday Kishore, Robert B. Sim, Patrice N. Marche   +6 more
openaire   +7 more sources

C1q Regulates Horizontal Cell Neurite Confinement in the Outer Retina

Frontiers in Neural Circuits, 2020
During development, neurons generate excess processes which are then eliminated in concert with circuit maturation. C1q is the initiating protein in the complement cascade and has been implicated in this process, but whether C1q-mediated elimination is ...
Courtney A. Burger, Courtney A. Burger, Danye Jiang, Danye Jiang, Fenge Li, Fenge Li, Melanie A. Samuel, Melanie A. Samuel   +7 more
doaj   +1 more source

Fundamental role of C1q in autoimmunity and inflammation [PDF]

, 2015
C1q, historically viewed as the initiating component of the classical complement pathway, also exhibits a variety of complement-independent activities in both innate and acquired immunity.
A Biro, A Nayak, A Nicholson-Weller, A Steino, AH Stephan, AH Stephan, AM Schmidt, B Ghebrehiwet, B Stevens, Betty Diamond, C Gaboriaud, CA Ogden, D Ricklin, D Scott, DA Bobak, DA Fraser, DA Fraser, E Brencicova, EV Clarke, F Santoro, Frances Santiago-Schwarz, H Paidassi, H Paidassi, HA Martens, I Baumann, J Leffler, J Rogers, JE Teixeira, K Duus, K Pisalyaput, KB Reid, KK Hosszu, KK Hosszu, L Kouser, L Meyaard, L Meyaard, L Shapiro, LA Trouw, LC Korb, M Botto, M Sarvari, M Son, M Son, M Yamada, MA Gill, MA Klein, MA Seelen, MD Galvan, ME Benoit, ME Benoit, ME Benoit, MJ Nordkamp, MJ Walport, MJ Walport, MM Zutter, Myoungsun Son, N Marto, P Eggleton, P Tacnet-Delorme, R Fan, RB Sim, RW Vandivier, S Sun, SD Yan, SS Bohlson, T Wyss-Coray, U Antes, US Gaipl, V Agnello, V Garlatti, W Bredt, W Cao, W Ma, Y Chu, Y Ma, ZG Ramirez-Ortiz   +75 more
core   +3 more sources

Neurodegeneration in multiple sclerosis

WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023
Chronic demyelination results in impaired axon metabolism and function, ultimately leading to progressive neurological decline. Neuroprotective strategies aim to protect axons from inflammatory‐mediated destruction, thereby improving axonal integrity and clinical disability (Image created in BioRender.com).
Gabrielle M. Mey, Kedar R. Mahajan, Tara M. DeSilva   +2 more
wiley   +1 more source

Glomerular C1q deposition and serum anti-C1q antibodies in anti-glomerular basement membrane disease [PDF]

, 2013
BACKGROUND: Anti-glomerular basement membrane (GBM) disease is a well-known antibody-induced autoimmune disease. A few patients have glomerular C1q deposition, but it is usually absent on renal histopathology.
Feng Yu, Ming-hui Zhao, Shui-yi Hu, Xiao-wei Yang, Xiao-yu Jia, Zhao Cui   +5 more
core   +1 more source

Symmetries and hidden symmetries of $(ε, d_L)$-twisted knot complements [PDF]

Algebr. Geom. Topol. 22 (2022) 601-656, 2019
In this paper we analyze symmetries, hidden symmetries, and commensurability classes of $(\epsilon, d_L)$-twisted knot complements, which are the complements of knots that have a sufficiently large number of twists in each of their twist regions. These knot complements can be constructed via long Dehn fillings on fully augmented links complements.
arxiv   +1 more source

Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia [PDF]

, 2011
Background Whereas the complement system alterations contribute to schizophrenia, complement receptors and regulators are little studied. We investigated complement receptor type 1 (CR1) expression on blood cells, the levels of circulating immune ...
A Boyajyan, A Erdei, A Monji, A Pillai, A Rochowiak, AL Hepburn, Anna Boyajyan, Aren Khoyetsyan, Arsen Arakelyan, BP Thornton, C Hess, D Liu, D McCarthy, David Poghosyan, DP Williams, DR Hanson, DT Fearon, E McGreal, F Bacle, Frantisek Mrazek, I Ghiran, I Ghiran, J Sambrook, JA Schifferli, JD Ogle, JG Wilson, JN Waitumbi, KR Mayilyan, KR Mayilyan, KR Mayilyan, LA Hebert, LB Klickstein, M Berger, M Bunce, M Katyal, M Krych-Goldberg, M Zorzetto, Martin Petrek, MD Kazatchkine, NR Kim, P Eggleton, PE Ruuska, R Khera, Roksana Zakharyan, Rouben Aroutiounian, S Hakobyan, S Hakobyan, S Mah, S Theodoropoulou, SY Yum, T Mardi, The World Health Organization, VL Serebruany   +52 more
core   +3 more sources

Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury

Science, 2021
Description Neuroinflammation after brain injury Traumatic brain injury affects millions of people every year and is a major cause of disability worldwide.
Stephanie S. Holden, F. Grandi, O. Aboubakr, Bryan Higashikubo, Frances S. Cho, Andrew H. Chang, A. Forero, Allison R. Morningstar, Vidhu K. Mathur, Logan J. Kuhn, Poojan Suri, S. Sankaranarayanan, Y. Andrews-Zwilling, A. Tenner, Anita Luthi, E. Aronica, M. Corces, T. Yednock, J. Paz   +18 more
semanticscholar   +1 more source

Potential of Murine IgG1 and Human IgG4 to Inhibit the Classical Complement and Fcγ Receptor Activation Pathways

Frontiers in Immunology, 2018
IgG antibodies (Abs) mediate their effector functions through the interaction with Fcγ receptors (FcγRs) and the complement factors. The main IgG-mediated complement activation pathway is induced through the binding of complement C1q to IgG Abs.
Gina-Maria Lilienthal, Johann Rahmöller, Johann Rahmöller, Janina Petry, Yannic C. Bartsch, Alexei Leliavski, Marc Ehlers, Marc Ehlers   +7 more
doaj   +1 more source