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Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]
, 2010 Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H. +4 more
core +1 more source
Clinical and Translational Science, Volume 16, Issue 1, Page 151-164, January 2023., 2023 Abstract This randomized, double‐blind, single‐ and multiple‐ascending dose study assessed the pharmacokinetics (PKs), pharmacodynamics, and safety of deucravacitinib (Sotyktu™), a selective and potent small‐molecule inhibitor of tyrosine kinase 2, in 100 (75 active, 25 placebo) healthy volunteers (NCT02534636).
Ian M. Catlett +6 more
wiley +1 more source
Complement Activation-Independent Attenuation of SARS-CoV-2 Infection by C1q and C4b-Binding Protein
Viruses, 2023 The complement system is a key component of the innate immune response to viruses and proinflammatory events. Exaggerated complement activation has been attributed to the induction of a cytokine storm in severe SARS-CoV-2 infection.
Nazar Beirag +9 more
doaj +1 more source
The non-inflammatory role of C1q during Her2/neu-driven mammary carcinogenesis [PDF]
, 2016 There is an ever increasing amount of evidence to support the hypothesis that complement C1q, the first component of the classical complement pathway, is involved in the regulation of cancer growth, in addition to its role in fighting infections.
Bandini, Silvio +12 more
core +1 more source
Complement is dispensable for neurodegeneration in Niemann-Pick disease type C
Journal of Neuroinflammation, 2012 Background The immune system has been implicated in neurodegeneration during development and disease. In various studies, the absence of complement (that is, C1q deficiency) impeded the elimination of apoptotic neurons, allowing survival.
Lopez Manuel E +2 more
doaj +1 more source
Complement component C1q is produced by isolated articular chondrocytes [PDF]
Osteoarthritis and Cartilage, 2019 Inflammation and innate immune responses may contribute to development and progression of Osteoarthritis (OA). Chondrocytes are the sole cell type of the articular cartilage and produce extracellular-matrix molecules. How inflammatory mediators reach chondrocytes is incompletely understood.
Rosalie Lubbers +11 more
openalex +6 more sources
Scientific Reports, 2018 C1q is known to perform several functions in addition to the role it plays in complement activation. C1q contains a collagen-like portion and DDR1 (discoidin domain receptor 1) is a well-known collagen receptor.
Ji-Hyun Lee +6 more
semanticscholar +1 more source
Effect of aging on bone metabolism: the involvement of complement C1q
Journal of Prosthodontic Research, 2021 Purpose Impairment of normal bone remodeling affects the successful osseointegration of dental implants. Recently, it has been reported that complement C1q level increases with age and delays wound healing by modulating Wnt signaling. As Wnt signaling is known to play an essential role in bone remodeling, we hypothesized that aging-dependent increases ...
Hiroshi Takeuchi +6 more
openaire +4 more sources
LifeThe interaction between IgM and C1q represents the first step of the classical pathway of the complement system in higher vertebrates. To identify the significance of particular IgM/C1q interactions, recombinant IgMs were used in both hexameric and ...
Maria Magdalena John +4 more
doaj +1 more source
Complement activation and protein adsorption by carbon nanotubes [PDF]
, 2006 As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel +5 more
core +2 more sources