Results 81 to 90 of about 729,206 (315)
Frontiers in Immunology, 2019 Complement C1q, the initiation molecule of the classical pathway, exerts various immunomodulatory functions independent of complement activation. Non-classical functions of C1q include the clearance of apoptotic cells and cholesterol crystals (CC), as ...
C. Donat +2 more
semanticscholar +1 more source
Heme Interacts with C1q and Inhibits the Classical Complement Pathway [PDF]
Journal of Biological Chemistry, 2011 C1q is the recognition subunit of the first component of the classical complement pathway. It participates in clearance of immune complexes and apoptotic cells as well as in defense against pathogens. Inappropriate activation of the complement contributes to cellular and tissue damage in different pathologies, urging the need for the development of ...
Boris P. Atanasov +15 more
openaire +4 more sources
Complement Receptor Type 1 (CR1, CD35) Is a Receptor for C1q [PDF]
, 1997 Molecular definition of the cellular receptor for the collagen domain of C1q has been elusive. We now report that C1q binds specifically to human CR1 (CD35), the leukocyte C3b/C4b receptor, and the receptor on erythrocytes for opsonized immune complexes.
Barbashov, Sergei F +4 more
core +1 more source
Role of Complement Component C1q in the Onset of Preeclampsia in Mice [PDF]
Hypertension, 2011 Preeclampsia (PE) is a life-threatening, pregnancy-induced disease and a leading cause of maternal and fetal morbidity and mortality. Despite considerable research, the causes of PE remain unclear, and there is no effective treatment.
Singh, Jameel +2 more
openaire +4 more sources
C1q nephropathy developing in a case of gastric carcinoma
Saudi Journal of Kidney Diseases and Transplantation, 2019 C1q is a key intermediary in the classical complement pathway. It is known to be activated by several factors including immunoglobulins and charged molecules and is an initiator of the complement cascade.
Kiran Preet Malhotra +4 more
doaj +1 more source
Autoantibodies against Complement C1q Specifically Target C1q Bound on Early Apoptotic Cells [PDF]
The Journal of Immunology, 2009 AbstractAutoantibodies against complement C1q (anti-C1q) are frequently found in patients with systemic lupus erythematosus (SLE). They strongly correlate with the occurrence of severe lupus nephritis, suggesting a pathogenic role in SLE. Because anti-C1q are known to recognize a neoepitope on bound C1q, but not on fluid-phase C1q, the aim of this ...
Bigler, Cornelia +4 more
openaire +3 more sources
Is serum complement C1q related to major depressive disorder?
Indian J Psychiatry, 2020 Major depressive disorder (MDD) has a high global incidence. While the pathogenesis of depression remains unknown, accumulating evidence has implicated inflammatory changes.The aim of the study is to compare the serum complement C1q levels in patients with MDD and healthy controls.The design was a case-control study.Blood samples were collected from ...
Yang J, Li R, Shi Y, Jiang S, Liu J.
europepmc +4 more sources
Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation. [PDF]
, 1993 Although very similar in sequence, the four subclasses of human immunoglobulin G (IgG) differ markedly in their ability to activate complement. Glu318-Lys320-Lys322 has been identified as a key binding motif for the first component of complement, C1q ...
Morrison, SL, Smith, RI, Tao, MH
core
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
Advanced Science, EarlyView.Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang +4 more
wiley +1 more source