Results 151 to 160 of about 796,318 (197)

Complement biosynthesis in human brain: Insights from single-nucleus transcriptomics of hippocampus

Nguyen VD, Bright M, Zhou Y, Morgan BP, Zelek WM.   +4 more
europepmc   +1 more source

Structures of the MASP Proteases and Comparison with Complement C1r and C1s [PDF]

, 2021
Several recognition proteins of the defence collagen family associate with proteases to initiate the complement cascade. The associated proteases, which are the subject of this review, mediate the proteolytic activation trigger. MBL-associated serine proteases (MASPs) mainly activate the lectin complement pathway (LP), while C1r and C1s activate the ...
C. Gaboriaud, V. Rossi, N. Thielens
semanticscholar   +3 more sources

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Clinical presentations and molecular basis of complement C1r deficiency in a male African–American patient with systemic lupus erythematosus

Lupus, 2011
Frank C Arnett
exaly   +2 more sources

Molecular cloning of the complement C1r/C1s/MASP2-like serine proteases from the common carp (Cyprinus carpio)

Immunogenetics, 2001
Tomoki Yano, Yoko Kato, K Fujiki
exaly   +2 more sources

Nucleotide sequence of the cDNA coding for human complement C1r.

Biochemistry, 1986
C1r is a zymogen of a serine protease that is involved in the activation of the first component of the classical pathway of the complement system. cDNAs coding for human C1r have been isolated from libraries prepared from poly(A) RNA from human liver and Hep G2 cells.
S. P. Leytus, K. Kurachi, K. Sakariassen, E. Davie   +3 more
semanticscholar   +3 more sources

Complement components C1r and C1s promote oral squamous cell carcinoma cell proliferation.

Journal of Oral Biosciences
OBJECTIVES Oral squamous cell carcinoma (OSCC), the most frequent cancer of the oral cavity, mostly arises from the mucosal epithelium and rarely from the odontogenic epithelium.
Thinh Thi Kim Truong, Tatsufumi Fujimoto, Shinsuke Fujii, Kari J Kurppa, Kana Hasegawa, Yudai Tajiri, Masafumi Moriyama, T. Kiyoshima   +7 more
semanticscholar   +3 more sources

Molecular Determinants of the Substrate Specificity of the Complement-initiating Protease, C1r [PDF]

Journal of Biological Chemistry, 2013
The serine protease, C1r, initiates activation of the classical pathway of complement, which is a crucial innate defense mechanism against pathogens and altered-self cells. C1r both autoactivates and subsequently cleaves and activates C1s. Because complement is implicated in many inflammatory diseases, an understanding of the interaction between C1r ...
Lakshmi C Wijeyewickrema, Theresa H T Coetzer, Renee C Duncan   +2 more
exaly   +3 more sources

A polymorphism in the complement component C1r is not associated with sporadic Alzheimer's disease

Neuroscience Letters, 2003
A growing body of evidence suggests that Alzheimer's disease (AD) is associated with local inflammation processes. Complement activation is one of the cardinal pathological features of the inflammation. Intensive AD association studies investigating polymorphisms in inflammatory-related genes have been recently performed, mainly in cytokines, but much ...
Hanna Rosenmann, Zeev Meiner, Esther Kahana   +2 more
exaly   +5 more sources

Revisiting the mechanism of the autoactivation of the complement protease C1r in the C1 complex: Structure of the active catalytic region of C1r

Molecular Immunology, 2008
C1r is a modular serine protease which is the autoactivating component of the C1 complex of the classical pathway of the complement system. We have determined the first crystal structure of the entire active catalytic region of human C1r. This fragment contains the C-terminal serine protease (SP) domain and the preceding two complement control protein (
József Kardos, Veronika Harmat, Orsolya Barabas   +2 more
exaly   +4 more sources