Results 271 to 280 of about 264,280 (300)

Complement components (C3, C4) in childhood asthma

The Indian Journal of Pediatrics, 2005
To assess the involvement of complements (C3, C4) in the pathophysiology of bronchial asthma.Selection of patients (n = 64) were made according to the recommended international criteria for diagnosis and classification of asthma. Serum levels of complement components (C3, C4) were measured by radial immunodiffusion technique in 64 Libyan children (age:
F I E, Najam, A S M, Giasuddin, A H, Shembesh   +2 more
openaire   +2 more sources

Intracerebral hemorrhage in complement C3-deficient mice

2006
The complement cascade is activated and contributes to brain damage after intracerebral hemorrhage (ICH). The present study investigated ICH-induced brain damage in complement C3-deficient mice. This study was divided into 2 parts. Male C3-deficient and C3-sufficient mice received an infusion of 30-microl autologous whole blood into the right basal ...
S, Yang, T, Nakamura, Y, Hua, R F, Keep, J G, Younger, J T, Hoff, G, Xi   +6 more
openaire   +2 more sources

Extrahepatic secreted complement C3 contributes to circulating C3 levels in humans

The Journal of Immunology, 1996
Abstract The majority of complement protein C3 is synthesized by the liver, but many other cell types produce small amounts of functionally active C3. The overall contribution of such extrahepatic C3 production to the total circulating C3 level is unknown.
M A, Naughton, M, Botto, M J, Carter, G J, Alexander, J M, Goldman, M J, Walport   +5 more
openaire   +2 more sources

Engineering of human complement component C3 for catalytic inhibition of complement

Immunology Letters, 2005
As a novel therapeutic approach in complement-mediated pathologies, we recently developed a human C3 derivative capable of obliterating functional complement by a catalytic, non-inhibitory mechanism. In this derivative, the C-terminal region of hC3 was substituted by a 275 amino acid sequence derived from the corresponding sequence of cobra venom ...
Johanna, Kölln, Reinhard, Bredehorst, Edzard, Spillner   +2 more
openaire   +2 more sources

Compound heterozygous complement C3 deficiency.

Immunology, 1995
Complete deficiency of the third component of the complement system is a result of defects in the two alleles of the C3 gene. In this study a family with C3 deficiency is reported; the parents expressed a distinct abnormality of the C3 gene and their two children had compound heterozygous C3 deficiency.
Y, Katz, R A, Wetsel, M, Schlesinger, Z, Fishelson   +3 more
openaire   +1 more source

Recent developments in C3-targeted complement therapeutics

Seminars in Immunology, 2022
Dimitrios C, Mastellos, John D, Lambris
openaire   +2 more sources

The state of complement in COVID-19

Nature Reviews Immunology, 2021
Behdad Afzali, Marina Noris, Bart N Lambrecht   +2 more
exaly  

Complement C3 Deficiency

2016
Arije Ghannam, Christian Drouet
openaire   +1 more source

Complement C3

2020
openaire   +1 more source

C3 RECEPTORS, COMPLEMENT DEFICIENCY AND SLE

Rheumatology, 1984
M, Walport, P, Lachmann
openaire   +2 more sources