Results 71 to 80 of about 976,787 (206)

Association of serum complement C3 with metabolic syndrome components in normal weight obese women

Journal of Diabetes and Metabolic Disorders, 2017
BackgroundIncreased serum complement C3 has been related to body fat mass, metabolic syndrome and chronic diseases. The purpose of this study was to evaluate the levels of C3 in the subjects of normal weight obese (hereafter NWO) as well as their ...
M. Karkhaneh, M. Qorbani, M. R. Mohajeri-Tehrani, S. Hoseini   +3 more
semanticscholar   +1 more source

Development and Optimization of an ELISA to Quantitate C3(H2O) as a Marker of Human Disease

Frontiers in Immunology, 2019
Discovery of a C3(H2O) uptake pathway has led to renewed interest in this alternative pathway triggering form of C3 in human biospecimens. Previously, a quantifiable method to measure C3(H2O), not confounded by other complement activation products, was ...
Michelle Elvington, M. Kathryn Liszewski, Alexis R. Liszewski, Hrishikesh S. Kulkarni, Ramsey R. Hachem, Thalachallour Mohanakumar, Alfred H. J. Kim, John P. Atkinson   +7 more
doaj   +1 more source

C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases [PDF]

Frontiers in Immunology, 2019
C3 glomerulopathy (C3G) is a severe kidney disease, which is caused by defective regulation of the alternative complement pathway. Disease pathogenesis is heterogeneous and is caused by both autoimmune and genetic factors. Here we characterized IgG autoantibodies derived from 33 patients with autoimmune C3 glomerulopathy.
Fei Zhao, Sara Afonso, Susanne Lindner, Andrea Hartmann, Ina Löschmann, Bo Nilsson, Kristina N. Ekdahl, Lutz T. Weber, Sandra Habbig, Gesa Schalk, Michael Kirschfink, Peter F. Zipfel, Peter F. Zipfel, Christine Skerka   +13 more
openaire   +4 more sources

Specific Evolution and Gene Family Expansion of Complement 3 and Regulatory Factor H in Fish

Frontiers in Immunology, 2020
The complement system comprises a large family of plasma proteins that play a central role in innate and adaptive immunity. To better understand the evolution of the complement system in vertebrates and the contribution of complement to fish immunity ...
Babak Najafpour, João C. R. Cardoso, Adelino V. M. Canário, Deborah M. Power   +3 more
doaj   +1 more source

Mutations in complement C3 from aHUS patients [PDF]

Blood, 2015
In this issue of Blood, Schramm et al demonstrate that the majority of mutations in complement C3 identified in atypical hemolytic uremic syndrome (aHUS) patients cause dysregulation in the alternative pathway of complement.
openaire   +3 more sources

Defining the Complement Biomarker Profile of C3 Glomerulopathy [PDF]

Clinical Journal of the American Society of Nephrology, 2014
C3 glomerulopathy (C3G) applies to a group of renal diseases defined by a specific renal biopsy finding: a dominant pattern of C3 fragment deposition on immunofluorescence. The primary pathogenic mechanism involves abnormal control of the alternative complement pathway, although a full description of the disease spectrum remains to be determined.
Zhang, Yuzhou, Nester, Carla M, Martin, Bertha, Skjoedt, Mikkel-Ole, Meyer, Nicole C, Shao, Dingwu, Borsa, Nicolò, Palarasah, Yaseelan, Smith, Richard J H   +8 more
openaire   +3 more sources

Hepatitis B virus inhibits the expression of complement C3 and C4, in vitro and in vivo.

Oncology Letters, 2018
The immune system serves an important function in Hepatitis B virus (HBV) infection, and the complement system is a major component of innate immunity. However, the regulatory effect of HBV on complement proteins has not yet been fully elucidated.
Chengliang Zhu, Hui Song, Fengxia Xu, W. Yi, Fang Liu, Xinghui Liu   +5 more
semanticscholar   +1 more source

Associations of Serum Complement Biomarkers With Adverse Clinical Outcomes Among Patients With Ischemic Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The complement system plays a crucial role in immune regulation and inflammatory response and is believed to be involved in the onset and progression of ischemic stroke.
Lulu Sun, Yong Wang, Yang Liu, Xinyue Chang, Xueyu Mao, Xuechun Wu, Min Chu, Huicong Niu, Mengyao Shi, Daoxia Guo, Zhengbao Zhu, Jing Zhao   +11 more
doaj   +1 more source

C3 glomerulopathy: a kidney disease mediated by alternative pathway deregulation

Frontiers in Nephrology
C3 glomerulopathy (C3G) is an ultra-rare complement-mediated kidney disease caused by to the deregulation of the alternative pathway (AP) of proximal complement.
Karin Heidenreich, Deepti Goel, P. S. Priyamvada, Sagar Kulkarni, Vipul Chakurkar, Dinesh Khullar, Ravi Singh, Charan Bale, Peter F. Zipfel   +8 more
doaj   +1 more source

Complement C3

, 2012
Complement C3 is the central component of the human complement system. It is ~186 kDa in size, consisting of an α-chain (~110 kDa) and a β-chain (~75 kDa) that are connected by cysteine bridges. C3 in its native form is inactive. Cleavage of C3 into C3b (~177 kDa) and C3a (~9 kDa) is a crucial step in the complement activation cascade, which can be ...
Dinasarapu, Ashok Reddy, Chandrasekhar, Anjana, Sahu, Arvind, Subramaniam, Shankar   +3 more
openaire   +1 more source