Results 61 to 70 of about 14,253 (157)

Concordant Patterns of Population Genetic Structure and Symbiont Communities in a Broadcasting Spawning Coral Along a Western Australian Fringing Reef

Ecology and Evolution, Volume 16, Issue 1, January 2026.
We explored fine‐scale patterns of connectivity and symbiont associations across the Ningaloo reefscape to inform on post‐disturbance recovery, larval dispersal capabilities, and recruitment dynamics. We detected low but significant population genetic structure among sample sites spread across Ningaloo Reef with the highest diversity in southern sites.
Shannon L. Duffy, W. Jason Kennington, Zoe T. Richards, Luke Thomas   +3 more
wiley   +1 more source

Dual Lewis Acid–Base Molecular Cages Facilitate Cooperative N2 Activation: Insights from Theory

ChemPhysChem, Volume 26, Issue 24, December 16, 2025.
Computational studies show dual Lewis acid–base molecular cages activating N2 via cooperative interactions. This highlights how molecular cage design can enable efficient nitrogen activation. Activating molecular nitrogen (N2) under ambient conditions remains a major challenge.
Holliness Nose, Fernando Ruipérez
wiley   +1 more source

Treatment of Plasmodium falciparum merozoites with the protease inhibitor E64 and mechanical filtration increases their susceptibility to complement activation.

PLoS ONE, 2020
Plasmodium falciparum malaria killed 451,000 people in 2017. Merozoites, the stage of the parasite that invades RBCs, are a logical target for vaccine development.
José A Stoute, Mary E Landmesser, Sergei Biryukov   +2 more
doaj   +1 more source

Functional Connectivity Associations With Markers of Disease Progression in GRN Pathogenic Variant Carriers

Annals of Clinical and Translational Neurology, Volume 12, Issue 12, Page 2575-2588, December 2025.
ABSTRACT Objective Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN‐related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression.
Taru M. Flagan, Stephanie A. Chu, Suvi Häkkinen, Liwen Zhang, David McFall, Jonathan D. Rohrer, Jesse A. Brown, Alex J. Lee, Kristen Fernhoff, Lorenzo Pasquini, Katherine P. Rankin, Maria Luisa Mandelli, Maria Luisa Gorno‐Tempini, Jennifer S. Yokoyama, Virginia E. Sturm, Brian Appleby, Bradford C. Dickerson, Kimiko Domoto‐Reilly, Tatiana Foroud, Daniel H. Geschwind, Nupur Ghoshal, Neill R. Graff‐Radford, Ging‐Yuek Robin Hsiung, Eric J. Huang, Edward Huey, Kejal Kantarci, Irene Litvan, Ian R. Mackenzie, Mario F. Mendez, Chiadi U. Onyike, Leonard Petrucelli, Eliana Marisa Ramos, Erik D. Roberson, Julio C. Rojas, Maria Carmela Tartaglia, Arthur W. Toga, Sandra Weintraub, Leah K. Forsberg, Hilary W. Heuer, Brad F. Boeve, Adam L. Boxer, Howard J. Rosen, Bruce L. Miller, Fermin Moreno, William W. Seeley, Suzee E. Lee, on behalf of the ALLFTD Consortium   +46 more
wiley   +1 more source

Enzymatic Reactions and Detection of C3 Cleavage Fragments

Bio-Protocol, 2014
The complement component C3 is the major effector molecule of the complement system. C3 circulates in the blood and interstitial fluids as pro-enzyme and is activated by enzymatic cleavage into a C3a portion, a classic anaphylatoxin that functions as ...
Claudia Kemper, Martin Kolev
doaj   +1 more source

Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery Systems

Advanced Therapeutics, Volume 8, Issue 12, December 2025.
This review explores how antibody engineering and display technologies are driving therapeutic advances against mosquito‐borne orthoflaviviruses such as Zika, dengue, and yellow fever viruses. It highlights diverse neutralizing targets on the envelope protein, including the conserved fusion loop, and discusses how Fc engineering, rational antigen ...
Ana Clara Barbosa Antonelli, Lucas Silva Rodrigues, Maria Clara Moura Pinheiro, Sylvia Barbosa Pinhate, Marcelo de Macedo Brígido, Andréa Queiroz Maranhão   +5 more
wiley   +1 more source

Pleural Mesothelial Cells-Induced Monocytes to the Pleural Cavity through the Effect of C3 Lytic Products in Tuberculous Pleural Effusion

International Journal of Clinical Practice
Background. The activation of complement is involved in monocyte recruitment in tuberculous pleural effusion (TPE), while the role of the cleavage product of complement C3 in this process needs further research. Methods.
Lisha Luo, Juntao Feng, Shuanglinzi Deng, Xinyue Hu, Bingrong Zhao, Wei Tang, Xiaozhao Li   +6 more
doaj   +1 more source

Factor H-related protein 1 promotes complement-mediated opsonization of Pseudomonas aeruginosa

Frontiers in Cellular and Infection Microbiology
Pseudomonas aeruginosa is an important human opportunistic pathogen responsible for a wide range of infections. The complement system is the main early host defense mechanism to control these infections. P.
Alex González-Alsina, Héctor Martín-Merinero, Margalida Mateu-Borrás, María Verd, Antonio Doménech-Sánchez, Joanna B. Goldberg, Santiago Rodríguez de Córdoba, Sebastián Albertí   +7 more
doaj   +1 more source

Factor H interferes with the adhesion of sickle red cells to vascular endothelium: a novel disease-modulating molecule

Haematologica, 2019
Sickle cell disease is an autosomal recessive genetic red cell disorder with a worldwide distribution. Growing evidence suggests a possible involvement of complement activation in the severity of clinical complications of sickle cell disease.
Elisabetta Lombardi, Alessandro Matte, Antonio M. Risitano, Daniel Ricklin, John D. Lambris, Denise De Zanet, Sakari T. Jokiranta, Nicola Martinelli, Cinzia Scambi, Gianluca Salvagno, Zeno Bisoffi, Chiara Colato, Angela Siciliano, Oscar Bortolami, Mario Mazzuccato, Francesco Zorzi, Luigi De Marco, Lucia De Franceschi   +17 more
doaj   +1 more source

Stimulation of the intracellular killing of Staphylococcus aureus by monocytes: regulation by immunoglobulin G and complement components C3/C3b and B/Bb. [PDF]

, 1982
P. C. J. Leijh, M T van den Barselaar, M. R. Daha, R. van Furth   +3 more
openalex   +1 more source