Results 21 to 30 of about 1,533 (97)

The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity [PDF]

, 2009
38 p.- 7 fig.Mutations and polymorphisms in the gene encoding factor H (CFH) have been associated with atypical haemolytic uraemic syndrome, dense deposit disease and age-related macular degeneration.
de Cordoba, Santiago Rodriguez, Harris, Claire Louise, Martinez-Barricarte, Ruben, Montes, Tamara, Morgan, Bryan Paul, Tortajada, Agustin   +5 more
core   +1 more source

Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes [PDF]

, 2017
C5 blockade by eculizumab prevents complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). However, C3-bound PNH red blood cells (RBCs), arising in almost all treated patients, may undergo extravascular hemolysis ...
A Hill, A Hill, A Nicholson-Weller, A Roth, AM Risitano, AM Risitano, AM Risitano, AM Risitano, AM Risitano, Antonio M. Risitano, B Nilsson, CE Schoot van der, DJ Araten, DS Holt, E Lach-Trifilieff, E Marchiafava, G Gronowicz, GL Logue, GV Seaman, J Nishimura, J Takeda, JD Tamerius, JE May, JP Atkinson, JV Dacie, L Luzzatto, L Luzzatto, L Luzzatto, M Bessler, M Harboe, M Kono, M Loschi, M Sica, M Sica, MA Lindorfer, Maria De Angioletti, MH Holguin, Michela Sica, MJ Harder, MK Pangburn, MK Pangburn, P Hillmen, P Hillmen, P Hillmen, Patrizia Ricci, PJ Lachmann, PJ Lachmann, RJ Kelly, RL Sparrow, Rosario Notaro, RP Latour de, RP Rother, S Berentsen, SK Krishnan, T Olutogun, T Rondelli, TH Ham, Tommaso Rondelli, UM Reiss, VM Holers, VP Ferreira, WF Rosse, WF Rosse, Z Fishelson, Z Lin   +64 more
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Zinc-induced self-association of complement C3b and Factor H: implications for inflammation and age-related macular degeneration. [PDF]

, 2013
The sub-retinal pigment epithelial deposits (sRPEds) that are a hallmark of age-related macular degeneration (AMD) contain both C3b and mM levels of zinc.
Gor, J, Lengyel, I, Nan, R, Pao, PJ, Perkins, SJ, Rodriguez, E, Tetchner, S   +6 more
core   +1 more source

Characterization of the lymphocyte membrane receptor for factor H (β1H- globulin) with an antibody to anti-factor H idiotype [PDF]

, 1982
Antibody to the binding site (idiotype) of anti-factor H was shown to have specificity for both B lymphocyte membrane H receptors and C3b. Goat F(ab’)(2) anti-human H was purified by absorption and elution from H agarose and used for rabbit immunization ...
Lambris, JD, Ross, GD
core   +3 more sources

Quantification of human complement C2 protein using an automated turbidimetric immunoassay [PDF]

, 2018
Background: The measurement of complement components is clinically useful where a deficiency is suspected, or where excessive activation and consumption are present in disease.
Brohet, Fabian, Cook, Alex, El-Shanawany, Tariq, Harding, Stephen, Johnson-Brett, Bridget, Jolles, Stephen, Parker, Antony Richard, Ponsford, Mark, Roberts, Andrew, Steven, Rachel, Stordeur, Patrick, Tange, Clare Elizabeth, Wallis, Gregg   +12 more
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Yersinia pestis targets neutrophils via complement receptor 3 [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111208/1/cmi12391 ...
Bohman, Lesley, Felek, Suleyman, Krukonis, Eric S., Marketon, Melanie M., Merritt, Peter M., Nero, Thomas   +5 more
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Identification of a C3bi-specific membrane complement receptor that is expressed on lymphocytes, monocytes, neutrophils, and erythrocytes [PDF]

, 1982
Cells expressing a membrane C receptor (CR(3)) specific for C3b-inactivator- cleaved C3b (C3bi) were identified by rosette assay with C3bi-coated sheep erythrocytes (EC3bi) or C3bi-coated fluorescent microspheres (C3bi-ms).
Lambris, JD, Ross, GD
core   +3 more sources

A Computational and Experimental Study of the Regulatory Mechanisms of the Complement System [PDF]

, 2010
The complement system is key to innate immunity and its activation is necessary for the clearance of bacteria and apoptotic cells. However, insufficient or excessive complement activation will lead to immune-related diseases. It is so far unknown how the
A Krarup, A Thern, AA Korotaevskiy, AF Zadura, AM Blom, AM Blom, AM Blom, Anna M. Blom, AP Sjoberg, AP Sjoberg, B Dahlback, B Liu, B Selander, Benjamin Leong, Bing Liu, Bow Ho, C Mold, CJ Langmead, D Ricklin, D Sheskin, David Hsu, DH Anderson, DT Fearon, DT Fearon, G Koh, H Hirayama, I Gigli, I Gigli, J Gunawardena, J Scharfstein, J Zhang, Jeak Ling Ding, JH Griffin, Jing Zhang, K Berggard, KP Murphy, KP Murphy, L Marnell, L Truedsson, LM Boerger, M Bozga, M Jaeger, M Matsushita, M Okroj, MH Kaplan, MJ Walport, MJ Walport, MV Suresh, N Rawal, NA van Riel, NV Prasadarao, P. S. Thiagarajan, Pei Yi Tan, PM Ng, R Veerhuis, Rustom Antia, S Hoops, S Jha, S Ram, SR Barnum, Sunil Sethi, T Fujita, T Meri, T Nordstrom, V Kirjavainen, X Ji, Z Fishelson, Z Zi   +67 more
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Pathogenesis of Foreign Body Infection: Description and Characteristics of an Animal Model [PDF]

, 2017
An animal model involving the subcutaneous implantation of tissue cages into guinea pigs and subsequent infection with Staphylococcus aureus was used to study factors pertinent to foreign body infection.
Nydegger, Urs E., Vaudaux, Pierre, Waldvogel, Francis A., Zimmerli, Werner   +3 more
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Complement system and alcoholic liver disease [PDF]

, 2008
Alcoholic liver disease (ALD) is a well recognized and growing health problem worldwide. ALD advances from fatty liver to inflammation, necrosis, fibrosis and cirrhosis.
Bykov, Igor
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