Results 81 to 90 of about 790,520 (218)

Complement Activation and Organ Damage After Trauma—Differential Immune Response Based on Surgical Treatment Strategy

Frontiers in Immunology, 2020
Background: The complement system is part of the innate immunity, is activated immediately after trauma and is associated with adult respiratory distress syndrome, acute lung injury, multiple organ failure, and with death of multiply injured patients ...
Ina Lackner, Birte Weber, Meike Baur, Giorgio Fois, Florian Gebhard, Roman Pfeifer, Paolo Cinelli, Sascha Halvachizadeh, Miriam Lipiski, Nikola Cesarovic, Hubert Schrezenmeier, Hubert Schrezenmeier, Markus Huber-Lang, Hans-Christoph Pape, Miriam Kalbitz   +14 more
doaj   +1 more source

Staphylococcal protein Ecb impairs complement receptor-1 mediated recognition of opsonized bacteria [PDF]

, 2017
Staphyloccus aureus is a major human pathogen leading frequently to sepsis and soft tissue infections with abscesses. Multiple virulence factors including several immune modulating molecules contribute to its survival in the host. When S.
A Troelstra, AJ McCarthy, AN Spaan, Bok-Luel Lee, C Blanc, CS Easmon, D Ricklin, D Serruto, DL Gordon, DT Fearon, DT Fearon, DT Fearon, ET Berends, F Bexborn, G Madico, GD Ross, H Amdahl, H Amdahl, H Sengelov, HA Verbrugh, Hanne Amdahl, I Jongerius, I Jongerius, I Jongerius, I Jongerius, J Nuutila, J Wu, JA Schifferli, JD Burman, Jos A. van Strijp, K Haapasalo, K Haupt, Karita Haapasalo, KF Austen, KM Cunnion, LA Benoit, LY Lee, Lydia Tan, M Berger, M Hammel, MA Hadders, MJ Walport, MK Boden, MK Pangburn, N Friberg, Pentti I. Kuusela, PW Dempsey, RD Schreiber, RF Todd 3rd, SC Mullaly, SH Rooijakkers, SL Newman, Suzan Rooijakkers, T Hallström, T Meri, T Meri, T. Sakari Jokiranta, Taru Meri, TE Mollnes, TK Koch, TS Jokiranta, V Koistinen, YP Ko   +62 more
core   +4 more sources

Yersinia enterocolitica O:3 Outer Membrane Vesicles as a Platform for Complement Activation

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
Basic characteristics and biological activity of outer membrane vesicles (OMVs) secreted by Yersinia enterocolitica O:3 (YeO3), depending on LPS chemotype and growth temperature. ABSTRACT Lipopolysaccharide (LPS) is the major component of the outer membrane vesicles (OMVs) of Gram‐negative bacteria.
Cédric Battaglino, Iryna Bodnaruk, Paula Czyszczoń, Mikael Skurnik, Beata Filip‐Psurska, Dariusz Jarych, Anna Maciejewska, Mariusz Gadzinowski, Kamil Malik, Izabela Potocka, Paweł Migdał, Roksana Kruszakin, Maciej Cedzyński, Katarzyna Kasperkiewicz, Jolanta Lukasiewicz, Anna S. Świerzko   +15 more
wiley   +1 more source

Development of a C3c-based ELISA method for the determination of anti-complementary potency of Bupleurum polysaccharides

Acta Pharmaceutica Sinica B, 2015
Traditionally, determination of inhibitory potency of complement inhibitors is performed by the hemolytic assay. However, this assay is not applicable to the lectin pathway, thus impeding the understanding of complement inhibitors against the overall ...
Mulu Wu, Hong Li, Yunyi Zhang, Daofeng Chen   +3 more
doaj   +1 more source

Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration. [PDF]

, 2016
PurposeTo redesign a complement-inhibiting peptide with the potential to become a therapeutic for dry and wet age-related macular degeneration (AMD).MethodsWe present a new potent peptide (Peptide 2) of the compstatin family.
Cabrera, Andrea P, Ghosh, Kaustabh, Gorham, Ronald D, Harrison, Reed ES, Johnson, Lincoln V, Mohan, Rohith R, Morikis, Dimitrios   +6 more
core   +1 more source

Dysregulation of Extracellular Vesicle Concentration, MicroRNAs, and Surface Proteins in Patients With Niemann‐Pick Disease Type C

Journal of Extracellular Biology, Volume 5, Issue 4, April 2026.
ABSTRACT Niemann‐Pick disease type C (NPC) is a rare neurodegenerative disease primarily caused by mutations in the NPC1 gene, which is associated with cholesterol trafficking impairment, and disruption of endolysosomal processing and extracellular vesicles (EVs).
Sarah Catherine BB Hawthorne, Ursula S Sandau, Trevor J McFarland, Elizabeth Berry‐Kravis, Julie A Saugstad   +4 more
wiley   +1 more source

Complement activation in experimental and human temporal lobe epilepsy

Neurobiology of Disease, 2007
We investigated the involvement of the complement cascade during epileptogenesis in a rat model of temporal lobe epilepsy (TLE), and in the chronic epileptic phase in both experimental as well as human TLE.
E. Aronica, K. Boer, E.A. van Vliet, S. Redeker, J.C. Baayen, W.G.M. Spliet, P.C. van Rijen, D. Troost, F.H. Lopes da Silva, W.J. Wadman, J.A. Gorter   +10 more
doaj   +1 more source

Yi Shen An, a Chinese traditional prescription, ameliorates membranous glomerulonephritis induced by cationic bovine serum albumin in rats

Pharmaceutical Biology, 2022
Context Yi Shen An (YSA) is an investigational composite of traditional Chinese medicine (Reference: 2010L000974) for the treatment of renal disease.
Yun-Li Zhao, Xiang-Hua Zhang, Feng Guo, Ying Wei, Jian-Hua Shang, Xiao-Dong Luo   +5 more
doaj   +1 more source

Machine Learning Model for an App‐Based Tool to Assist With the Diagnosis of Canine Atopic Dermatitis

Veterinary Dermatology, Volume 37, Issue 2, Page 236-246, April 2026.
Canine atopic dermatitis (cAD) is a chronic condition requiring life‐long management. Accurate diagnosis can be challenging, with no reliable diagnostic test. This study aimed to generate a simple diagnostic model for cAD. This model is a relevant prototype for an app‐based tool to support general practitioners in the diagnosis of cAD alongside ...
Xavier Langon, Mathieu Montoya, Isabelle Gourdon   +2 more
wiley   +1 more source

Immune complexes and complement in serum and synovial fluid of rheumatoid arthritis patients [PDF]

Journal of Medical Biochemistry, 2009
Rheumatoid arthritis (RA) is predominantly an intraarticular inflammatory and autoimmune disease that involves different autoantibodies and effector mechanisms.
Mijušković Zoran, Rackov Ljiljana, Pejović Janko, Živanović Sandra, Stojanović Jelica, Kovačević Zoran   +5 more
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