Results 41 to 50 of about 942,109 (243)

Preferential association of hepatitis C virus with CD19+ B cells is mediated by complement system [PDF]

, 2016
Extrahepatic disease manifestations are common in chronic hepatitis C virus (HCV) infection. The mechanism of HCV-related lymphoproliferative disorders is not fully understood.
Alter, Harvey J., Baré, Patricia, De Giorgi, Valeria, Grandinetti, Teresa, Matsuura, Kentaro, Salam, Kazi Abdus, Schechterly, Cathy, Wang, Richard   +7 more
core   +1 more source

Pharmacological management of immune and oxidative disturbances in patients with encephalopathy on the background of hypertension [PDF]

, 2016
Inclusion of a comprehensive drug treatment of patients with discirculatory encephalopathy cerebrolysin combination with meksidol normalizes the concentration of C3 and C4 components of the complement system, IgG, malondialdehyde, catalase activity ...
Bistrova, N. A., Shulginova, A. A., Voronina, E. Yu.   +2 more
core   +2 more sources

Renal C3 complement component: feed forward to diabetic kidney disease [PDF]

, 2015
BACKGROUND: Diabetic nephropathy is the main cause of end-stage renal disease and has reached epidemic proportions. METHODS: Comprehensive genomic profiling (RNAseq) was employed in the ZS (F1 hybrids of Zucker and spontaneously hypertensive heart ...
Dominguez, Jesus H., Kelly, Katherine J., Liu, Yunlong, Zhang, Jizhong   +3 more
core   +2 more sources

Low copy numbers of complement C4 and homozygous deficiency of C4A may predispose to severe disease and earlier disease onset in patients with systemic lupus erythematosus

Lupus, 2017
Objectives Low copy numbers and deletion of complement C4 genes are potent risk factors for systemic lupus erythematosus (SLE). However, it is not known whether this genetic association affects the clinical outcome.
M. Jüptner, Friederike Flachsbart, Amke Caliebe, Wolfgang Lieb, Stefan Schreiber, R. Zeuner, Andre Franke, Johann O. Schröder   +7 more
semanticscholar   +1 more source

Elevated levels of C3, C4, and CH50 of the complement system in ICU and non‐ICU patients with COVID‐19

Health Science Reports, 2022
Purpose SARS‐CoV‐2 infection has spread in each corner of the world. Many health systems have dealt with it intensively. The complement system is an instrumental component in the inflammatory immune response and plays a role in the activation of blood ...
Ahmad Bagherimoghaddam, Houshang Rafatpanah, Hassan Mansouritorghabeh   +2 more
doaj   +1 more source

Cutaneous vasculitis and recurrent infection caused by deficiency in complement factor I [PDF]

, 2018
Cutaneous leukocytoclastic vasculitis arises from immune complex deposition and dysregulated complement activation in small blood vessels. There are many causes, including dysregulated host response to infection, drug reactions, and various autoimmune ...
Despina Eleftheriou, Ebun Omoyinmi, Kimberly Gilmour, Nigel Klein, Paul A. Brogan, Radhika Ramnath, Sira Nanthapisal, Sira Nanthapisal, Valentina Leone, Ying Hong   +9 more
core   +2 more sources

Association of Complement-Related Proteins in Subjects With and Without Second Trimester Gestational Diabetes

Frontiers in Endocrinology, 2021
IntroductionGestational Diabetes Mellitus (GDM) development is related to underlying metabolic syndrome that is associated with elevated complement C3 and C4.
Manjunath Ramanjaneya, Manjunath Ramanjaneya, Alexandra E. Butler, Meis Alkasem, Mohammed Bashir, Jayakumar Jerobin, Jayakumar Jerobin, Angela Godwin, Abu Saleh Md Moin, Lina Ahmed, Mohamed A. Elrayess, Steven C. Hunt, Stephen L. Atkin, Abdul-Badi Abou-Samra   +13 more
doaj   +1 more source

Unclassified autoimmune pancreatitis mimicking pancreatic cancer [PDF]

, 2019
A 24-year-old black male presented with a 1-week obstructive jaundice and intermittent abdominal pain, with no significant weight loss and an unsuspicious abdominal exam.
Alves, A, Marinho, R, Nunes, V, Pignatelli, N   +3 more
core   +1 more source

Altered Complement System Activity in Schizophrenia: Overexpression of C4 and/or Abnormal Expression of Complement Control Proteins in the DLPFC, Parietal Cortex, Temporal Cortex, Associative Striatum, Hippocampus, Cerebellum and Whole Blood

European Psychiatry, 2022
Introduction In schizophrenia, abnormal synaptic pruning during adolescence may be due to an altered Complement system activity. While this hypothesis is supported by C4 overexpression in various brain regions of individuals with schizophrenia, such ...
R. Rey, M. Leboyer
doaj   +1 more source

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H., Mitchell, Daniel A., Schmid, Ralf, Schwaeble, Wilhelm J., Wallis, Russell   +4 more
core   +1 more source