Results 41 to 50 of about 905,894 (352)

Pharmacological management of immune and oxidative disturbances in patients with encephalopathy on the background of hypertension [PDF]

, 2016
Inclusion of a comprehensive drug treatment of patients with discirculatory encephalopathy cerebrolysin combination with meksidol normalizes the concentration of C3 and C4 components of the complement system, IgG, malondialdehyde, catalase activity ...
Bistrova, N. A., Shulginova, A. A., Voronina, E. Yu.   +2 more
core   +2 more sources

Evaluation of serum complement C4 among COVID-19 patients in Khartoum state: a case control-based study [version 1; peer review: 2 approved]

F1000Research, 2023
Background: The complement system is made up of an abundance of unique plasma proteins that play an important role in innate immunity and inflammation, aiding in the fight against pathogenic microbes and viral diseases.
Babbiker Mohammed Taher Gorish, Yousif Ali Rahamtalla, Mohammed Yahya, Nasr Mohammed Nasr   +3 more
doaj  

Association of Complement-Related Proteins in Subjects With and Without Second Trimester Gestational Diabetes

Frontiers in Endocrinology, 2021
IntroductionGestational Diabetes Mellitus (GDM) development is related to underlying metabolic syndrome that is associated with elevated complement C3 and C4.
Manjunath Ramanjaneya, Manjunath Ramanjaneya, Alexandra E. Butler, Meis Alkasem, Mohammed Bashir, Jayakumar Jerobin, Jayakumar Jerobin, Angela Godwin, Abu Saleh Md Moin, Lina Ahmed, Mohamed A. Elrayess, Steven C. Hunt, Stephen L. Atkin, Abdul-Badi Abou-Samra   +13 more
doaj   +1 more source

Altered Complement System Activity in Schizophrenia: Overexpression of C4 and/or Abnormal Expression of Complement Control Proteins in the DLPFC, Parietal Cortex, Temporal Cortex, Associative Striatum, Hippocampus, Cerebellum and Whole Blood

European Psychiatry, 2022
Introduction In schizophrenia, abnormal synaptic pruning during adolescence may be due to an altered Complement system activity. While this hypothesis is supported by C4 overexpression in various brain regions of individuals with schizophrenia, such ...
R. Rey, M. Leboyer
doaj   +1 more source

Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4.

Acta Crystallographica Section D: Structural Biology, 2016
While the rapid proliferation of high-resolution structures in the Protein Data Bank provides a rich set of templates for starting models, it remains the case that a great many structures both past and present are built at least in part by hand-threading
T. Croll, G. Andersen
semanticscholar   +1 more source

Structural Model for Factor X Inhibition of IgM and Complement-Mediated Neutralization of Adenovirus

Viruses, 2023
Adenovirus has strong therapeutic potential as an oncolytic virus and gene therapy vector. However, injecting human species C serotype 5 adenovirus, HAdv-C5, into the bloodstream leads to numerous interactions with plasma proteins that affect viral ...
Nicole Wagner, Dmitry M. Shayakhmetov, Phoebe L. Stewart   +2 more
doaj   +1 more source

Renal C3 complement component: feed forward to diabetic kidney disease [PDF]

, 2015
BACKGROUND: Diabetic nephropathy is the main cause of end-stage renal disease and has reached epidemic proportions. METHODS: Comprehensive genomic profiling (RNAseq) was employed in the ZS (F1 hybrids of Zucker and spontaneously hypertensive heart ...
Dominguez, Jesus H., Kelly, Katherine J., Liu, Yunlong, Zhang, Jizhong   +3 more
core   +1 more source

Clinical Characteristics of Patients With IgG4-Related Disease Complicated by Hypocomplementemia

Frontiers in Immunology, 2022
BackgroundA proportion of patients with immunogloblin G (IgG) 4-related disease (IgG4-RD) have hypocomplementemia. We aimed to identify characteristics of such patients.MethodsWe analyzed the demographic and clinical data and complement levels of 85 ...
Yuya Fujita, Yuya Fujita, Shoichi Fukui, Masataka Umeda, Sosuke Tsuji, Naoki Iwamoto, Yoshikazu Nakashima, Yoshiro Horai, Takahisa Suzuki, Akitomo Okada, Toshiyuki Aramaki, Yukitaka Ueki, Akinari Mizokami, Tomoki Origuchi, Hiroshi Watanabe, Kiyoshi Migita, Atsushi Kawakami   +16 more
doaj   +1 more source

Unclassified autoimmune pancreatitis mimicking pancreatic cancer [PDF]

, 2019
A 24-year-old black male presented with a 1-week obstructive jaundice and intermittent abdominal pain, with no significant weight loss and an unsuspicious abdominal exam.
Alves, A, Marinho, R, Nunes, V, Pignatelli, N   +3 more
core   +1 more source

Serum complements and immunoglobulin profiles in systemic lupus erythematosus patients: An observational study at a teaching hospital

Journal of Family Medicine and Primary Care, 2022
Context: Serum complement proteins and autoantibodies play an important role in the pathogenesis and diagnosis of systemic lupus erythematosus (SLE). Abnormalities in various immunoglobulin levels are described in patients of SLE.
Ranjan Singh Rana, Bitan Naik, Mahima Yadav, Usha Singh, Anup Singh, Shailja Singh   +5 more
doaj   +1 more source