Cutaneous vasculitis and recurrent infection caused by deficiency in complement factor I [PDF]
, 2018 Cutaneous leukocytoclastic vasculitis arises from immune complex deposition and dysregulated complement activation in small blood vessels. There are many causes, including dysregulated host response to infection, drug reactions, and various autoimmune ...
Despina Eleftheriou +9 more
core +2 more sources
Unclassified autoimmune pancreatitis mimicking pancreatic cancer [PDF]
, 2019 A 24-year-old black male presented with a 1-week obstructive jaundice and intermittent abdominal pain, with no significant weight loss and an unsuspicious abdominal exam.
Alves, A +3 more
core +1 more source
Amniotic fluid embolism pathophysiology suggests the new diagnostic armamentarium: β-tryptase and complement fractions C3-C4 are the indispensable working tools [PDF]
, 2015 Amniotic fluid embolism (AFE) is an uncommon obstetric condition involving pregnant women during labor or in the initial stages after delivery. Its incidence is estimated to be around 5.5 cases per 100,000 deliveries.
Busardo', FRANCESCO PAOLO +3 more
core +5 more sources
European Psychiatry, 2022 Introduction In schizophrenia, abnormal synaptic pruning during adolescence may be due to an altered Complement system activity. While this hypothesis is supported by C4 overexpression in various brain regions of individuals with schizophrenia, such ...
R. Rey, M. Leboyer
doaj +1 more source
Complement C4 - A Genetic Marker in Arthritides [PDF]
International Journal of Human Genetics, 2004 KEYWORDS Complement C4; juvenile arthritis; rheumatoid arthritis; osteo arthritis; phenotypes; arthritides ABSTRACT The present study aims at evaluating the role of complement C4 and its specific eletromorphic association with arthritides. C4 typing of the serum samples was carried out by PAGE on 41 juvenile arthritis, 101 rheumatoid arthritis, 25 ...
A. Padmini, Ravi Babu, N. Pratibha
openaire +2 more sources
Hepatitis C virus NS3/4A protease inhibits complement activation by cleaving complement component 4.
PLoS ONE, 2013 BackgroundIt has been hypothesized that persistent hepatitis C virus (HCV) infection is mediated in part by viral proteins that abrogate the host immune response, including the complement system, but the precise mechanisms are not well understood.
Seiichi Mawatari +15 more
doaj +1 more source
Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation [PDF]
, 2018 Background The longstanding association between the major histocompatibility complex (MHC) locus and schizophrenia (SZ) risk has recently been accounted for, partially, by structural variation at the complement component 4 (C4) gene.
A. Corvin +13 more
core +3 more sources
SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis. [PDF]
, 2016 Blood-feeding insects inject potent salivary components including complement inhibitors into their host's skin to acquire a blood meal. Sand fly saliva was shown to inhibit the classical pathway of complement; however, the molecular identity of the ...
Abdeladhim, M. +18 more
core +1 more source
Complement system biomarkers in first episode psychosis [PDF]
, 2019 Several lines of evidence implicate immunological/inflammatory factors in development of schizophrenia. Complement is a key driver of inflammation, and complement dysregulation causes pathology in many diseases.
Di Forti, Marta +8 more
core +2 more sources
Macrophage-Derived Complement Component C4 Can Restore Humoral Immunity in C4-Deficient Mice [PDF]
The Journal of Immunology, 2002 Abstract Mice with a disrupted C4 locus (C4−/−) have an impaired immune response to thymus-dependent Ags. To test the role of bone marrow-derived C4 in humoral immunity, we reconstituted deficient animals with wild-type bone marrow or an enriched fraction of bone marrow-derived macrophages.
Mihaela, Gadjeva +6 more
openaire +2 more sources