Results 21 to 30 of about 515,713 (283)
Journal of Marine Science and Engineering, 2023 In the evolution of the complement system, a major humoral innate immune factor, the existence of multiple isotypes of the complement components is considered as a key strategy to enhance innate immune defense. Complement C4 is also diversified in a wide
Rosli Nehlah +4 more
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Sanamed, 2022 Introduction: Burns, depending on the degree of severity, induce a significant pathophysiological response in the body. The complement system participates in the body's defenses as well as in immune responses after burn-induced trauma. Objectives: The
Arslanagic Selma, Karamehic Jasenko
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Frontiers in Genetics, 2021 Schizophrenia is a common neuropsychiatric disorder with complex pathophysiology. Recent reports suggested that complement system alterations contributed to pathological synapse elimination that was associated with psychiatric symptoms in schizophrenia ...
Yu Chen +11 more
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The complement component C4 of mammals [PDF]
Biochemical Journal, 1990 Human complement component C4 is coded by tandem genes located in the HLA class III region. The products of the two genes, C4A and C4B, are different in their activity. This difference is due to a degree of ‘substrate’ specificity in the covalent binding reactions of the two isotypes. Mouse also has a duplicated locus, but only one gene produces active
A W, Dodds, S K, Law
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Complement content in plasma under different storage conditions
Zhongguo shuxue zazhi, 2023 Objective To investigate the changes in complement content in component blood before blood transfusion. Methods 180 samples from 20 plasma donors were collected at different stages of the preparation process, stored at different temperatures and time ...
Zhi HAN, Yujie HAN, Haihong ZHANG
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The Assessment of Complement Proteins in Patients With Severe COVID-19 [PDF]
International Journal of Basic Science in Medicine, 2021 Introduction: The complement system, consisting of more than 20 soluble proteins, has a crucial role in innate immunity and inflammation and eliminates pathogens and viral infections.
Ali Ghazavi +4 more
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Complement C4 Prevents Viral Infection through Capsid Inactivation.
Cell Host Microbe, 2019 The complement system is vital for anti-microbial defense. In the classical pathway, pathogen-bound antibody recruits the C1 complex (C1qC1r2C1s2) that initiates a cleavage cascade involving C2, C3, C4, and C5 and triggering microbial clearance.
Bottermann M +15 more
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Hypocomplementemia during tocilizumab treatment
Medicine, 2022 . Hypocomplementemia has been reported in patients with rheumatoid arthritis treated with tocilizumab (TCZ), but its long-term consequences are unknown.
Amir Bieber, MD +6 more
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Increased activation product of complement 4 protein in plasma of individuals with schizophrenia
Translational Psychiatry, 2021 Structural variation in the complement 4 gene (C4) confers genetic risk for schizophrenia. The variation includes numbers of the increased C4A copy number, which predicts increased C4A mRNA expression.
Agnieszka Kalinowski +14 more
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Frontiers in Immunology, 2020 Background: Vitamin D and complement components shared some common pathophysiological pathways in the musculoskeletal system, circulation, and metabolism, which were linked to physical function.
Chi Zhang +8 more
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