Results 41 to 50 of about 515,713 (283)

Biochemical and functional studies on mouse ficolin-B, a novel pattern recognition molecule of the innate immune system [PDF]

, 2011
Ficolins are members of the collectin family of proteins which in human and mice are able to recognize pathogen associated molecular patterns (PAMPs) on microbial surfaces.
Elumalai, Preetham
core   +1 more source

Elevated levels of C3, C4, and CH50 of the complement system in ICU and non‐ICU patients with COVID‐19

Health Science Reports, 2022
Purpose SARS‐CoV‐2 infection has spread in each corner of the world. Many health systems have dealt with it intensively. The complement system is an instrumental component in the inflammatory immune response and plays a role in the activation of blood ...
Ahmad Bagherimoghaddam, Houshang Rafatpanah, Hassan Mansouritorghabeh   +2 more
doaj   +1 more source

Association of Complement-Related Proteins in Subjects With and Without Second Trimester Gestational Diabetes

Frontiers in Endocrinology, 2021
IntroductionGestational Diabetes Mellitus (GDM) development is related to underlying metabolic syndrome that is associated with elevated complement C3 and C4.
Manjunath Ramanjaneya, Manjunath Ramanjaneya, Alexandra E. Butler, Meis Alkasem, Mohammed Bashir, Jayakumar Jerobin, Jayakumar Jerobin, Angela Godwin, Abu Saleh Md Moin, Lina Ahmed, Mohamed A. Elrayess, Steven C. Hunt, Stephen L. Atkin, Abdul-Badi Abou-Samra   +13 more
doaj   +1 more source

Hepatitis C virus NS3/4A protease inhibits complement activation by cleaving complement component 4.

PLoS ONE, 2013
BackgroundIt has been hypothesized that persistent hepatitis C virus (HCV) infection is mediated in part by viral proteins that abrogate the host immune response, including the complement system, but the precise mechanisms are not well understood.
Seiichi Mawatari, Hirofumi Uto, Akio Ido, Kenji Nakashima, Tetsuro Suzuki, Shuji Kanmura, Kotaro Kumagai, Kohei Oda, Kazuaki Tabu, Tsutomu Tamai, Akihiro Moriuchi, Makoto Oketani, Yuko Shimada, Masayuki Sudoh, Ikuo Shoji, Hirohito Tsubouchi   +15 more
doaj   +1 more source

A gammaherpesvirus complement regulatory protein promotes initiation of infection by activation of protein kinase Akt/PKB. [PDF]

, 2010
Viruses have evolved to evade the host's complement system. The open reading frames 4 (ORF4) of gammaherpesviruses encode homologs of regulators of complement activation (RCA) proteins, which inhibit complement activation at the level of C3 and C4 ...
Stewart, James P., Stipan, J., Adler, Heiko, James P Stewart, Adler Barbara, Adler, Barbara, Heiko Adler, Beatrix Steer, Barbara Adler, Jonjic Stipan, Stipan Jonjic, Steer, Beatrix, Steer Beatrix, Steer, B., Adler Heiko, Stewart James P., Adler, H., Adler, B., Jonjic, Stipan, James P. Stewart, Stewart, J.P.   +20 more
core   +1 more source

A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP) [PDF]

, 2007
Includes bibliographical references (leaves 96-114).Cowpox virus has been found to encode the inflammation modulatory protein (IMP) (Miller, C.G., 1997), a homologue vaccinia virus complement control protein (VCP). VCP belongs to regulation of complement
Paulsen, Janis
core   +1 more source

Structural Model for Factor X Inhibition of IgM and Complement-Mediated Neutralization of Adenovirus

Viruses, 2023
Adenovirus has strong therapeutic potential as an oncolytic virus and gene therapy vector. However, injecting human species C serotype 5 adenovirus, HAdv-C5, into the bloodstream leads to numerous interactions with plasma proteins that affect viral ...
Nicole Wagner, Dmitry M. Shayakhmetov, Phoebe L. Stewart   +2 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Evaluation of complement components C3 and C4 in serum of patient with neoplastic diseases

مجلة علوم ذي قار, 2019
The aim of this study is to evaluate the level of complement components C3 and C4 in serum of cancer patients to find which activation pathway of the complment system has the more effect in these cases .
Zeenah weheed Atwan, Shereen Jawad Al-Ali, Mohamed Abbas Mehdy   +2 more
doaj   +4 more sources

Altered Complement System Activity in Schizophrenia: Overexpression of C4 and/or Abnormal Expression of Complement Control Proteins in the DLPFC, Parietal Cortex, Temporal Cortex, Associative Striatum, Hippocampus, Cerebellum and Whole Blood

European Psychiatry, 2022
Introduction In schizophrenia, abnormal synaptic pruning during adolescence may be due to an altered Complement system activity. While this hypothesis is supported by C4 overexpression in various brain regions of individuals with schizophrenia, such ...
R. Rey, M. Leboyer
doaj   +1 more source