Results 11 to 20 of about 515,713 (283)

Complement C4, Infections, and Autoimmune Diseases [PDF]

Frontiers in Immunology, 2021
Complement C4, a key molecule in the complement system that is one of chief constituents of innate immunity for immediate recognition and elimination of invading microbes, plays an essential role for the functions of both classical (CP) and lectin (LP ...
Hongbin Wang, Hongbin Wang, Hongbin Wang, Mengyao Liu   +3 more
doaj   +5 more sources

High plasma complement C4 levels as a novel predictor of clinical outcome in intracerebral hemorrhage [PDF]

Frontiers in Aging Neuroscience, 2023
ObjectiveThe complement cascade is activated and contributes to the brain injury after intracerebral hemorrhage (ICH). Complement component 4 (C4), an important component of complement cascade, has been associated with severity of neurological impairment
Moxin Wu, Moxin Wu, Kai Chen, Min Jiang, Fusheng Xie, Xianming Cao, Liang Chen, Zhiying Chen, Zhiying Chen, Xiaoping Yin, Xiaoping Yin   +10 more
doaj   +2 more sources

Evaluation of serum complement C4 among COVID-19 patients in Khartoum state: a case control-based study [version 1; peer review: 2 approved] [PDF]

F1000Research, 2023
Background: The complement system is made up of an abundance of unique plasma proteins that play an important role in innate immunity and inflammation, aiding in the fight against pathogenic microbes and viral diseases.
Babbiker Mohammed Taher Gorish, Yousif Ali Rahamtalla, Mohammed Yahya, Nasr Mohammed Nasr   +3 more
doaj   +2 more sources

Effect of Low Complement C4 on Clinical Characteristics of Patients with First-Episode Neuromyelitis Optica Spectrum Disorder [PDF]

Neuropsychiatric Disease and Treatment, 2021
Chunyang Pan, Yi Zhao, Haojie Xie, Yongyan Zhou, Ranran Duan, Yanfei Li, Yanjie Jia, Tao Peng Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaCorrespondence: Tao PengDepartment of ...
Pan C, Zhao Y, Xie H, Zhou Y, Duan R, Li Y, Jia Y, Peng T   +7 more
doaj   +2 more sources

Complement C4 exacerbates astrocyte-mediated neuroinflammation and promotes α-synuclein pathology in Parkinson’s disease [PDF]

npj Parkinson's Disease
Complement C4, implicated in neuroinflammation and synaptic dysfunction, plays a poorly defined role in Parkinson’s disease (PD). Here, we demonstrate elevated C4 levels in PD patient plasma and the substantia nigra of α-synuclein preformed fibril (α-syn
Wenkai Zou, Liang Kou, Yiming Wang, Zongjie Jin, Nian Xiong, Tao Wang, Yun Xia   +6 more
doaj   +2 more sources

Rapid activation of the complement system by cuprophane depends on complement component C4 [PDF]

Kidney International, 1998
Hemodialysis with cuprophane dialyzer membranes promotes rapid activation of the complement system, which is thought to be mediated by the alternative pathway. Complete hereditary deficiency of complement C4, a classical pathway component, in two hemodialysis patients provided the opportunity to investigate a possible role of the classical pathway.
Lhotta, Karl, Würzner, Reinhard, Kronenberg, Florian, Oppermann, Martin, König, Paul   +4 more
openaire   +4 more sources

Comparison of serum C3, C3a, C4 levels between cataract patients with and without pseudoexfoliation and normal individuals [PDF]

BMC Ophthalmology
Background We aimed to compare serum complement C3, C3a, and C4 levels between cataract patients with and without pseudoexfoliation syndrome, and to compare these groups with the control group. Methods There were three different groups in the study.
Gülce Gökgöz Özışık, Hüseyin Kayadibi, İsmail Çağatay Çağlar, Hasan Basri Çakmak   +3 more
doaj   +2 more sources

Clinical significance of serum complement levels and C3/C4 ratio in IgA nephropathy: histopathological correlates and prognostic implications [PDF]

Renal Failure
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Complement activation plays a central role in its pathogenesis; however, the prognostic significance of serum complement levels remains unclear.
Gamze Ergun, Emrullah Tasdemir, Umut Kasapoglu, Arzu Ozdemir   +3 more
doaj   +2 more sources

Complement C4, C4A and C4a – What they do and how they differ [PDF]

Brain, Behavior, & Immunity - Health
Meike Heurich, Melanie Föcking, David Cotter   +2 more
doaj   +2 more sources

Associations Between Complement C4, Habitual Constipation, and Sleep Disturbance in Oldest-Old and Centenarian Chinese Adults. [PDF]

J Inflamm Res
Zhigao Sun,1,* Yan Nie,2,* Jianqiu Pei,3,* Ming Gao,4,* Zhe Luan,5,* Yali Zhao,6 Zhaoxing Li,7 Shihui Fu8,9 1Traditional Chinese Medicine Department, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, People ...
Sun Z, Nie Y, Pei J, Gao M, Luan Z, Zhao Y, Li Z, Fu S.   +7 more
europepmc   +2 more sources