Results 11 to 20 of about 49,973 (249)

The complement component C4 of mammals [PDF]

Biochemical Journal, 1990
Human complement component C4 is coded by tandem genes located in the HLA class III region. The products of the two genes, C4A and C4B, are different in their activity. This difference is due to a degree of ‘substrate’ specificity in the covalent binding reactions of the two isotypes. Mouse also has a duplicated locus, but only one gene produces active
A W, Dodds, S K, Law
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Complement content in plasma under different storage conditions

Zhongguo shuxue zazhi, 2023
Objective To investigate the changes in complement content in component blood before blood transfusion. Methods 180 samples from 20 plasma donors were collected at different stages of the preparation process, stored at different temperatures and time ...
Zhi HAN, Yujie HAN, Haihong ZHANG
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The Assessment of Complement Proteins in Patients With Severe COVID-19 [PDF]

International Journal of Basic Science in Medicine, 2021
Introduction: The complement system, consisting of more than 20 soluble proteins, has a crucial role in innate immunity and inflammation and eliminates pathogens and viral infections.
Ali Ghazavi, Ghasem Mosayebi, Nafiesh Keshavarzian, Somayeh Rabiemajd, Ali Ganji   +4 more
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Hypocomplementemia during tocilizumab treatment

Medicine, 2022
. Hypocomplementemia has been reported in patients with rheumatoid arthritis treated with tocilizumab (TCZ), but its long-term consequences are unknown.
Amir Bieber, MD, Doron Markovits, MD, PhD, Kohava Toledano, MD, Yonit Tavor, MD, Reuven Mader, MD, Alexandra Balbir-Gurman, MD, Yolanda Braun-Moscovici, MD   +6 more
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Increased activation product of complement 4 protein in plasma of individuals with schizophrenia

Translational Psychiatry, 2021
Structural variation in the complement 4 gene (C4) confers genetic risk for schizophrenia. The variation includes numbers of the increased C4A copy number, which predicts increased C4A mRNA expression.
Agnieszka Kalinowski, Joanna Liliental, Lauren A. Anker, Omer Linkovski, Collin Culbertson, Jacob N. Hall, Reenal Pattni, Chiara Sabatti, Douglas Noordsy, Joachim F. Hallmayer, Elizabeth D. Mellins, Jacob S. Ballon, Ruth O’Hara, Douglas F. Levinson, Alexander E. Urban   +14 more
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Associations Between Complement Components and Vitamin D and the Physical Activities of Daily Living Among a Longevous Population in Hainan, China

Frontiers in Immunology, 2020
Background: Vitamin D and complement components shared some common pathophysiological pathways in the musculoskeletal system, circulation, and metabolism, which were linked to physical function.
Chi Zhang, Chi Zhang, Shihui Fu, Minghao Zhao, Deping Liu, Deping Liu, Yali Zhao, Yao Yao, Yao Yao   +8 more
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Complement C4 allotypes and psoriasis.

Clinical Chemistry, 1989
Complement C4 allotypes were studied in a group of 100 patients with psoriasis vulgaria. Frequency of C4A and C4B allotypes in 46 randomly selected unrelated healthy subjects of the same ethnic origin, previously described, was taken as a control pattern.
Čvorišćec, Dubravka, Stavljenić Rukavina, Ana, Vukelić, B.   +2 more
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Elevated levels of C3, C4, and CH50 of the complement system in ICU and non‐ICU patients with COVID‐19

Health Science Reports, 2022
Purpose SARS‐CoV‐2 infection has spread in each corner of the world. Many health systems have dealt with it intensively. The complement system is an instrumental component in the inflammatory immune response and plays a role in the activation of blood ...
Ahmad Bagherimoghaddam, Houshang Rafatpanah, Hassan Mansouritorghabeh   +2 more
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Association of Complement-Related Proteins in Subjects With and Without Second Trimester Gestational Diabetes

Frontiers in Endocrinology, 2021
IntroductionGestational Diabetes Mellitus (GDM) development is related to underlying metabolic syndrome that is associated with elevated complement C3 and C4.
Manjunath Ramanjaneya, Manjunath Ramanjaneya, Alexandra E. Butler, Meis Alkasem, Mohammed Bashir, Jayakumar Jerobin, Jayakumar Jerobin, Angela Godwin, Abu Saleh Md Moin, Lina Ahmed, Mohamed A. Elrayess, Steven C. Hunt, Stephen L. Atkin, Abdul-Badi Abou-Samra   +13 more
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Hepatitis C virus NS3/4A protease inhibits complement activation by cleaving complement component 4.

PLoS ONE, 2013
BackgroundIt has been hypothesized that persistent hepatitis C virus (HCV) infection is mediated in part by viral proteins that abrogate the host immune response, including the complement system, but the precise mechanisms are not well understood.
Seiichi Mawatari, Hirofumi Uto, Akio Ido, Kenji Nakashima, Tetsuro Suzuki, Shuji Kanmura, Kotaro Kumagai, Kohei Oda, Kazuaki Tabu, Tsutomu Tamai, Akihiro Moriuchi, Makoto Oketani, Yuko Shimada, Masayuki Sudoh, Ikuo Shoji, Hirohito Tsubouchi   +15 more
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