Complement C4A Regulates Autoreactive B Cells in Murine Lupus [PDF]
Cell Reports, 2020 Summary: Systemic lupus erythematosus (SLE) is a severe autoimmune disease mediated by pathogenic autoantibodies. While complement protein C4 is associated with SLE, its isoforms (C4A and C4B) are not equal in their impact.
Léa Simoni +6 more
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Clinical features of patients with homozygous complement C4A or C4B deficiency. [PDF]
PLoS ONE, 2018 IntroductionHomozygous deficiencies of complement C4A or C4B are detected in 1-10% of populations. In genome-wide association studies C4 deficiencies are missed because the genetic variation of C4 is complex.
Inka Liesmaa +4 more
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Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction. [PDF]
PLoS ONE, 2012 Low protein levels and copy number variation (CNV) of the fourth component of human complement (C4A and C4B) have been associated with various diseases. High-throughput methods for analysing C4 CNV are available, but they commonly do not detect the most ...
Riitta Paakkanen +5 more
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Real-time PCR quantification of human complement C4A and C4B genes [PDF]
BMC Genetics, 2006 Background The fourth component of human complement (C4), an essential factor of the innate immunity, is represented as two isoforms (C4A and C4B) in the genome.
Fust George +5 more
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Genetic mapping of complement system proteins for islet autoimmunity in children with high risk of T1D [PDF]
Communications BiologyRecent studies have reported the involvement of complement system proteins in the initiation and progression of islet autoimmunity (IA) in the study of Type 1 diabetes (T1D).
Xiaowei Hu +10 more
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Increase in Comforting Behavior (Allogrooming) During Social Interaction in Male Mice Deficient for the Slp Gene of Complement Component C4 [PDF]
Brain SciencesBackground: Oxytocin (OT) is a nonapeptide hormone produced in the hypothalamus, released into the brain and peripheral circulation, and plays a key role in social behavior.
Yasuhiko Yamamoto +13 more
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Hepatic steatosis in postmenopausal women is characterized by distinct serum extracellular vesicle proteomic signatures [PDF]
BMC MedicineBackground Metabolic dysfunction-associated steatotic liver disease (MASLD) is common among midlife women. Circulating extracellular vesicles (EVs) carry bioactive cargo that may mediate or reflect disease processes, but their role in hepatic steatosis ...
Patrick Pirrotte +11 more
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PLoS ONE, 2012 There was an error in the Competing Interests statement. The correct Competing interests are: MLL is working as a consultant at a company owned by the University of Helsinki providing complement C4 analysis for diagnostic samples. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. The other authors
Paakkanen, Riitta +5 more
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Complement C4, C4A and C4a – What they do and how they differ
Brain, Behavior, & Immunity - HealthMeike Heurich +2 more
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Complement Cascades and Brain Disorders [PDF]
BiomoleculesThe complement system is a vital component of innate immunity. Besides its roles in pathogen defense, its significance in neurodevelopment, neurodegeneration, and cancer progression is beginning to be recognized.
Ivana Jovčevska +2 more
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