Results 11 to 20 of about 11,949 (217)

Complement C4A Regulates Autoreactive B Cells in Murine Lupus [PDF]

Cell Reports, 2020
Summary: Systemic lupus erythematosus (SLE) is a severe autoimmune disease mediated by pathogenic autoantibodies. While complement protein C4 is associated with SLE, its isoforms (C4A and C4B) are not equal in their impact.
Léa Simoni, Jessy Presumey, Cees E. van der Poel, Carlos Castrillon, Sarah E. Chang, Paul J. Utz, Michael C. Carroll   +6 more
doaj   +5 more sources

Clinical features of patients with homozygous complement C4A or C4B deficiency. [PDF]

PLoS ONE, 2018
IntroductionHomozygous deficiencies of complement C4A or C4B are detected in 1-10% of populations. In genome-wide association studies C4 deficiencies are missed because the genetic variation of C4 is complex.
Inka Liesmaa, Riitta Paakkanen, Asko Järvinen, Ville Valtonen, Marja-Liisa Lokki   +4 more
doaj   +5 more sources

Real-time PCR quantification of human complement C4A and C4B genes [PDF]

BMC Genetics, 2006
Background The fourth component of human complement (C4), an essential factor of the innate immunity, is represented as two isoforms (C4A and C4B) in the genome.
Fust George, Szilassy Denes, Blasko Bernadett, Szilagyi Agnes, Sasvari-Szekely Maria, Ronai Zsolt   +5 more
doaj   +5 more sources

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction. [PDF]

PLoS ONE, 2012
Low protein levels and copy number variation (CNV) of the fourth component of human complement (C4A and C4B) have been associated with various diseases. High-throughput methods for analysing C4 CNV are available, but they commonly do not detect the most ...
Riitta Paakkanen, Hanna Vauhkonen, Katja T Eronen, Asko Järvinen, Mikko Seppänen, Marja-Liisa Lokki   +5 more
doaj   +6 more sources

Complement factor C4a does not activate protease‐activated receptor 1 (PAR1) or PAR4 on human platelets [PDF]

Research and Practice in Thrombosis and Haemostasis, 2021
Background Protease‐activated receptor (PAR) 1 and PAR4 are key thrombin signal mediators for human platelet activation and aggregation in response to vascular injury.
Xu Han, Maria de la Fuente, Marvin T. Nieman   +2 more
doaj   +2 more sources

Correction: Copy Number Analysis of Complement C4A, C4B and C4A Silencing Mutation by Real-Time Quantitative Polymerase Chain Reaction

PLoS ONE, 2012
There was an error in the Competing Interests statement. The correct Competing interests are: MLL is working as a consultant at a company owned by the University of Helsinki providing complement C4 analysis for diagnostic samples. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. The other authors
Riitta Paakkanen, Hanna Vauhkonen, Katja T. Eronen, Asko Järvinen, Mikko Seppänen, Marja‐Liisa Lokki   +5 more
doaj   +6 more sources

Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases [PDF]

Frontiers in Immunology, 2016
The complement system consists of effector proteins, regulators, and receptors that participate in host defense against pathogens. Activation of the complement system, via the classical pathway (CP), has long been recognized in immune complex-mediated ...
Katherine eLintner, Yee Ling eWu, Yan eYang, Charles eSpencer, Georges eHauptmann, Lee eHebert, John eAtkinson, Chack-Yung eYu   +7 more
doaj   +11 more sources

Genetic mapping of complement system proteins for islet autoimmunity in children with high risk of T1D [PDF]

Communications Biology
Recent studies have reported the involvement of complement system proteins in the initiation and progression of islet autoimmunity (IA) in the study of Type 1 diabetes (T1D).
Xiaowei Hu, Bobbie-Jo M. Webb-Robertson, Hemang M. Parikh, Ernesto S. Nakayasu, Suna Onengut-Gumuscu, Wei-Min Chen, Ashley Frazer-Abel, Thomas O. Metz, Stephen S. Rich, Marian J. Rewers, Ani Manichaikul   +10 more
doaj   +2 more sources

Increase in Comforting Behavior (Allogrooming) During Social Interaction in Male Mice Deficient for the Slp Gene of Complement Component C4 [PDF]

Brain Sciences
Background: Oxytocin (OT) is a nonapeptide hormone produced in the hypothalamus, released into the brain and peripheral circulation, and plays a key role in social behavior.
Yasuhiko Yamamoto, Anpei Zhang, Anna A. Shabalova, Ai Harashima, Kyota Fujita, Teruko Yuhi, Yu Oshima, Pinyue Fu, Sei-ichi Munesue, Kana Minami, Kazuhiro Higashida, Hirokazu Kumazaki, Chiharu Tsuji, Haruhiro Higashida   +13 more
doaj   +2 more sources

Sample processing time but not storage time affects complement activation markers C4a, C4d, C3a, iC3b, Bb, C5a, and sC5b-9 levels in EDTA-plasma of individuals at clinical high-risk for psychosis

Biomarkers in Neuropsychiatry
The complement system is an important part of the innate immune system and plays a key role in inflammatory processes. Concentrations of complement activation fragments in plasma are markers of systemic activation and have been found to be altered in a ...
Eleftheria Kodosaki, Colm Healy, Jonah F. Byrne, Melanie Föcking, Mary Cannon, Diana O. Perkins, David Cotter, Meike Heurich   +7 more
doaj   +3 more sources