Results 21 to 30 of about 675,301 (233)
Detection of both isotypes of complement C4, C4A and C4B, in normal human glomeruli
Kidney International, 1986 Monoclonal antibodies reactive against the complement C4A and C4B isotypic components were used in an immunoperoxidase technique for the histological study of normal human renal tissue. Prominent staining with both antibodies was seen in the mesangial areas of all normal kidney sections investigated.
Helmut E. Feucht +7 more
openaire +4 more sources
Annals of Saudi Medicine, 2004 Background Genetic susceptibility to systemic lupus erythematosus (SLE) varies among populations. Few data exist on associations of HLA class II and class III alleles of the major histocompatibility complex (MHC) and susceptibility to SLE in Tunisians ...
K. Ayed +3 more
semanticscholar +2 more sources
Frontiers in GeneticsIntroduction: Age-related macular degeneration (AMD) is the leading cause of central vision loss in the elderly. One-third of the genetic contribution to this disease remains unexplained.Methods: We analyzed targeted sequencing data from two independent ...
Johanna M. Seddon +9 more
doaj +2 more sources
Genetic basis of human complement C4A deficiency. Detection of a point mutation leading to nonexpression. [PDF]
Journal of Clinical Investigation, 1993 The fourth component of the human complement system (C4) is coded for by two genes, C4A and C4B, located within the MHC. Null alleles of C4 (C4Q0) are defined by the absence of C4 protein in plasma. These null alleles are due either to large gene deletions or to nonexpression of the respective genes.
Peter M. Schneider +2 more
openaire +4 more sources
Complement Split Products C3a and C4a in Chronic Lyme Disease [PDF]
Scandinavian Journal of Immunology, 2008 AbstractComplement split products C3a and C4a are reportedly elevated in patients with acute Lyme disease. We have now examined these immunologic markers in patients with chronic Lyme disease compared to appropriate disease controls. The study population consisted of 29 healthy controls, 445 patients with chronic Lyme disease, 11 patients with systemic
V. R. Savely +3 more
openaire +4 more sources
Complement activation by heparin-protamine complexes during cardiopulmonary bypass: Effect of C4A null allele [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 1997 The first objective was to determine the effect of inherited differences in the classic pathway complement protein C4 on complement activation by heparin-protamine complexes in cardiac surgery. Specifically, we hypothesized that patients with heterozygous C4A null phenotype (A0BB), who have decreased amounts of C4A, may have increased complement ...
Saif Rehman +4 more
openaire +4 more sources
Association between copy number variation of complement component C4 and Graves' disease [PDF]
Journal of Biomedical Science, 2011 Background Gene copy number of complement component C4, which varies among individuals, may determine the intrinsic strength of the classical complement pathway.
Chang, Chwen-Tzuei +7 more
core +5 more sources
Restriction fragment analysis of duplication of the fourth component of complement (C4A)
Genomics, 1988 The two genes encoding the fourth component of complement (C4A and C4B) reside between HLA-B and HLA-DR on human chromosome 6. Two kilobases downstream from each C4 gene lies a 21-hydroxylase gene (CA21HA and CA21HB, respectively). Utilizing the method of Southern blotting and a 5'-end 2.4-kb BamHI/KpnI fragment of the C4 cDNA, we have analyzed TaqI ...
Robert H. McLean +5 more
openaire +4 more sources
Heterogeneity in the structural basis of the human complement C4A null allele (C4A*Q0) as revealed by HindIII restriction fragment length polymorphism analysis [PDF]
FEBS Letters, 1987 The highly polymorphic fourth component of human complement (C4) is usually encoded by two genes, C4A and C4B, adjacent to the 21‐hydroxylase (21‐OH) genes, 21‐OHA and 21‐OHB, and is also remarkable in the high frequency of the ‘null’ alleles, C4A*Q0 and C4B*Q0.
Nathalie Vegnaduzzi +5 more
openaire +4 more sources
Complete Complement Components C4A and C4B Deficiencies in Human Kidney Diseases and Systemic Lupus Erythematosus [PDF]
The Journal of Immunology, 2004 Abstract Although a heterozygous deficiency of either complement component C4A or C4B is common, and each has a frequency of ∼20% in a Caucasian population, complete deficiencies of both C4A and C4B proteins are extremely rare. In this paper the clinical courses for seven complete C4 deficiency patients are described in detail, and the ...
Yang, Yan +5 more
openaire +6 more sources