Results 21 to 30 of about 6,275 (172)

Complement C4, Infections, and Autoimmune Diseases

Frontiers in Immunology, 2021
Complement C4, a key molecule in the complement system that is one of chief constituents of innate immunity for immediate recognition and elimination of invading microbes, plays an essential role for the functions of both classical (CP) and lectin (LP ...
Hongbin Wang, Hongbin Wang, Hongbin Wang, Mengyao Liu   +3 more
doaj   +1 more source

Identification of altered plasma proteins by proteomic study in valvular heart diseases and the potential clinical significance. [PDF]

PLoS ONE, 2013
BackgroundLittle is known about genetic basis and proteomics in valvular heart disease (VHD) including rheumatic (RVD) and degenerative (DVD) valvular disease.
Ge Gao, Chao Xuan, Qin Yang, Xiao-Cheng Liu, Zhi-Gang Liu, Guo-Wei He   +5 more
doaj   +1 more source

Opposite Profiles of Complement in Antiphospholipid Syndrome (APS) and Systemic Lupus Erythematosus (SLE) Among Patients With Antiphospholipid Antibodies (aPL)

Frontiers in Immunology, 2019
APS is the association of antiphospholipid antibodies (aPL) with thromboses and/or recurrent pregnancy loss (RPL). Among patients with SLE, one-third have aPL and 10–15% have a manifestation of secondary APS.
Stephanie L. Savelli, Stephanie L. Savelli, Stephanie L. Savelli, Robert A. S. Roubey, Kathryn J. Kitzmiller, Kathryn J. Kitzmiller, Danlei Zhou, Danlei Zhou, Danlei Zhou, Haikady N. Nagaraja, Evan Mulvihill, Evan Mulvihill, Fatima Barbar-Smiley, Fatima Barbar-Smiley, Stacy P. Ardoin, Stacy P. Ardoin, Yee Ling Wu, Yee Ling Wu, Yee Ling Wu, Chack-Yung Yu, Chack-Yung Yu, Chack-Yung Yu   +21 more
doaj   +1 more source

Complement Activation in Patients with Focal Segmental Glomerulosclerosis. [PDF]

PLoS ONE, 2015
Recent pre-clinical studies have shown that complement activation contributes to glomerular and tubular injury in experimental FSGS. Although complement proteins are detected in the glomeruli of some patients with FSGS, it is not known whether this is ...
Joshua M Thurman, Maria Wong, Brandon Renner, Ashley Frazer-Abel, Patricia C Giclas, Melanie S Joy, Diana Jalal, Milena K Radeva, Jennifer Gassman, Debbie S Gipson, Frederick Kaskel, Aaron Friedman, Howard Trachtman   +12 more
doaj   +1 more source

Systemic Alterations of Immune Response-Related Proteins during Glaucoma Development in the Murine Model DBA/2J

Diagnostics, 2020
Animal models of glaucoma, a neurodegenerative disease affecting the retina, offer the opportunity to study candidate molecular biomarkers throughout the disease.
Andrés Fernández-Vega Cueto, Lydia Álvarez, Montserrat García, Enol Artime, Ana Álvarez Barrios, Ignacio Rodríguez-Uña, Miguel Coca-Prados, Héctor González-Iglesias   +7 more
doaj   +1 more source

Profiling Complement System Components in Primary CNS Vasculitis

Cells, 2021
Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji, Christian W. Keller, Simon Koch, Heinz Wiendl, Christian Gerloff, Tim Magnus, Jan D. Lünemann   +6 more
doaj   +1 more source

Impact of C4, C4A and C4B gene copy number variation in the susceptibility, phenotype and progression of systemic lupus erythematosus

Advances in Rheumatology, 2019
Background Complement component 4 (C4) gene copy number (GCN) affects the susceptibility to systemic lupus erythematosus (SLE) in different populations, however the possible phenotype significance remains to be determined.
Kaline Medeiros Costa Pereira, Sandro Perazzio, Atila Granado A. Faria, Eloisa Sa Moreira, Viviane C. Santos, Marcelle Grecco, Neusa Pereira da Silva, Luis Eduardo Coelho Andrade   +7 more
doaj   +1 more source

Age-Related Maculopathy Susceptibility 2 and Complement Factor H Polymorphism and Intraocular Complement Activation in Neovascular Age-Related Macular Degeneration

Ophthalmology Science, 2022
Purpose: To investigate the association of risk alleles in complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) with complement activation products in the aqueous humor in eyes with neovascular age-related macular degeneration ...
Yutaka Kato, MD, Yasuharu Oguchi, MD, PhD, Tomoko Omori, PhD, Akihito Kasai, MD, Masashi Ogasawara, MD, Yukinori Sugano, MD, PhD, Kanako Itagaki, MD, Akira Ojima, MD, PhD, Yumi Ishida, Takeshi Machida, PhD, Hideharu Sekine, MD, PhD, Tetsuju Sekiryu, MD, PhD   +11 more
doaj   +1 more source

Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases

Frontiers in Immunology, 2016
The complement system consists of effector proteins, regulators, and receptors that participate in host defense against pathogens. Activation of the complement system, via the classical pathway (CP), has long been recognized in immune complex-mediated ...
Katherine eLintner, Yee Ling eWu, Yan eYang, Charles eSpencer, Georges eHauptmann, Lee eHebert, John eAtkinson, Chack-Yung eYu   +7 more
doaj   +1 more source

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients. [PDF]

PLoS ONE, 2014
BackgroundNon-tuberculous mycobacteria (NTM) are ubiquitous in the environment and they infect mainly persons with underlying pulmonary diseases but also previously healthy elderly women.
Hannele Kotilainen, Marja-Liisa Lokki, Riitta Paakkanen, Mikko Seppänen, Pentti Tukiainen, Seppo Meri, Tuija Poussa, Jussi Eskola, Ville Valtonen, Asko Järvinen   +9 more
doaj   +1 more source