Hepatic steatosis in postmenopausal women is characterized by distinct serum extracellular vesicle proteomic signatures [PDF]
BMC MedicineBackground Metabolic dysfunction-associated steatotic liver disease (MASLD) is common among midlife women. Circulating extracellular vesicles (EVs) carry bioactive cargo that may mediate or reflect disease processes, but their role in hepatic steatosis ...
Patrick Pirrotte +11 more
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Complement Cascades and Brain Disorders [PDF]
BiomoleculesThe complement system is a vital component of innate immunity. Besides its roles in pathogen defense, its significance in neurodevelopment, neurodegeneration, and cancer progression is beginning to be recognized.
Ivana Jovčevska +2 more
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Complement system in dermatological diseases – fire under the skin [PDF]
Frontiers in Medicine, 2015 The complement system plays a key role in several dermatological diseases. Overactivation, deficiency or abnormality of the control proteins are often related to a skin disease.
Jaana Helena Panelius +4 more
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Complement C4, C4A and C4a – What they do and how they differ
Brain, Behavior, & Immunity - HealthMeike Heurich +2 more
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Proteomic and In Silico Analyses Highlight Complement System’s Role in Bladder Cancer Immune Regulation [PDF]
MedicinaBackground and Objectives: Bladder cancer (BLCA), intimately associated with the immune system, represents a substantial global health burden due to its high recurrence rates and limited therapeutic effectiveness.
Tuğcan Korak +5 more
doaj +2 more sources
Distinct effects of complement C4A and C4B copy number in Systemic Sclerosis serological and clinical subtypes [PDF]
Arthritis &Rheumatology, Accepted Article.Objective Complement component 4 (C4), encoded by C4A and C4B within the major histocompatibility complex (MHC) on chromosome 6, regulates the immune response and clears immune complexes. Variable copy number (CN) of C4 genes and retroviral HERV‐K element influence its function.
Javier Martínez‐López +22 more
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Complement anaphylatoxin C4a inhibits C5a-induced neointima formation following arterial injury
Molecular Medicine Reports, 2014 Interactions between complement anaphylatoxins have been investigated in numerous fields; however, their functions during arterial remodeling following injury have not been studied. The inhibitory effect of complement anaphylatoxin C4a on neointima formation induced by C5a following arterial injury was investigated.
Yan Zhao +3 more
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Complete Complement Components C4A and C4B Deficiencies in Human Kidney Diseases and Systemic Lupus Erythematosus [PDF]
The Journal of Immunology, 2004 Abstract Although a heterozygous deficiency of either complement component C4A or C4B is common, and each has a frequency of ∼20% in a Caucasian population, complete deficiencies of both C4A and C4B proteins are extremely rare. In this paper the clinical courses for seven complete C4 deficiency patients are described in detail, and the ...
Yan Yang +5 more
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Novel potential interacting partners of fibronectin in spontaneous animal model of interstitial cystitis [PDF]
, 2012 Feline idiopathic cystitis (FIC) is the only spontaneous animal model for human interstitial cystitis (IC), as both possess a distinctive chronical and relapsing character. Underlying pathomechanisms of both diseases are not clearly established yet.
Amann, Barbara +6 more
core +10 more sources