Results 31 to 40 of about 675,301 (233)

Sensitive and Specific Real-Time Polymerase Chain Reaction Assays to Accurately Determine Copy Number Variations (CNVs) of Human Complement C4A, C4B, C4-Long, C4-Short, and RCCX Modules: Elucidation of C4 CNVs in 50 Consanguineous Subjects with Defined HLA Genotypes1 [PDF]

Journal of Immunology, 2007
Yee-Ling Wu, S. Savelli, Yan Yang, Bi Zhou, B. Rovin, D. Birmingham, H. Nagaraja, L. Hebert, Y. Yu   +8 more
semanticscholar   +2 more sources

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new‐onset type 1 diabetes patients [PDF]

Pediatric Diabetes, 2012
S. Kingery, Yee-Ling Wu, Bi Zhou, R. Hoffman, C. Y. Yu   +4 more
semanticscholar   +2 more sources

Hysteresis of human complement C4A to C4B binding in hemolytic activities and inhibition by immune complex aggregates

Journal of Immunology, 2023
--Human complement C4 is a sophisticated innate immune effector that features two classes of polymorphic proteins with acidic C4A and basic C4B. The thioester carbonyl from Gln-1016 of C4A has high binding affinity towards protein antigens rich in ...
Danlei Zhou, Xiaoping Liu, Samantha L. Coss, Chack-Yung Yu   +3 more
semanticscholar   +1 more source

Bgl II polymorphic site upstream to the human complement component C4A gene [PDF]

Nucleic Acids Research, 1987
Olafur Jensson, R Fossdal, A Arnason, Astridur Palsdottir   +3 more
openaire   +5 more sources

Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication.

Journal of Biological Chemistry, 1994
L. Shen, Lai-Chu Wu, S. Sanlioglu, R. Chen, Anna R. Mendoza, A. Dangel, Michael C. Carroll, W. Zipf, C. Y. Yu   +8 more
semanticscholar   +2 more sources

Increased activation product of complement 4 protein in plasma of individuals with schizophrenia

Translational Psychiatry, 2021
Structural variation in the complement 4 gene (C4) confers genetic risk for schizophrenia. The variation includes numbers of the increased C4A copy number, which predicts increased C4A mRNA expression.
Agnieszka Kalinowski, Joanna Liliental, Lauren A. Anker, Omer Linkovski, Collin Culbertson, Jacob N. Hall, Reenal Pattni, Chiara Sabatti, Douglas Noordsy, Joachim F. Hallmayer, Elizabeth D. Mellins, Jacob S. Ballon, Ruth O’Hara, Douglas F. Levinson, Alexander E. Urban   +14 more
doaj   +1 more source

Changes in complement activation products after anti-VEGF injection for choroidal neovascularization in age-related macular degeneration and pachychoroid disease

Scientific Reports, 2021
We evaluated changes in the complement system resulting from anti-vascular endothelial growth factor (VEGF) in eyes with age-related choroidal neovascularization (CNV) including neovascular age-related macular degeneration, pachychoroid neovasculopathy ...
Keiichiro Tanaka, Yasuharu Oguchi, Tomoko Omori, Yumi Ishida, Hiroaki Shintake, Ryutaro Tomita, Akihito Kasai, Masashi Ogasawara, Yukinori Sugano, Kanako Itagaki, Akira Ojima, Takeshi Machida, Hideharu Sekine, Tetsuju Sekiryu   +13 more
doaj   +1 more source

Complement component 4A protein levels are negatively related to frontal volumes in patients with schizophrenia spectrum disorders [PDF]

, 2023
Background: Excessive C4A-gene expression may result in increased microglia-mediated synaptic pruning. As C4A overexpression is observed in schizophrenia spectrum disorders (SSD), this mechanism may account for the altered brain morphology (i.e.
de Witte, L. D., Gangadin, S. S., Gelderman, K. A., Germann, M., Mandl, R. C.W., Sommer, I. E.C.   +5 more
core   +1 more source

Trichorhinophalangeal syndrome type I and systemic lupus erythematosus with complement C4A homozygous null alleles in the same family.

Annals of the Rheumatic Diseases, 1989
Solbritt Rantapaa
semanticscholar   +2 more sources

Novel potential interacting partners of fibronectin in spontaneous animal model of interstitial cystitis [PDF]

, 2012
Feline idiopathic cystitis (FIC) is the only spontaneous animal model for human interstitial cystitis (IC), as both possess a distinctive chronical and relapsing character. Underlying pathomechanisms of both diseases are not clearly established yet.
Amann, Barbara, Deeg, Cornelia A., Dorsch, Roswitha, Euler, Kerstin N., Hartmann, Katrin, Hauck, Stefanie M., Treutlein, Gudrun   +6 more
core   +5 more sources