Results 31 to 40 of about 11,949 (217)
Serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C. [PDF]
World J Hepatol, 2013 Behairy BE +4 more
europepmc +3 more sources
Insights into the Antibacterial Properties of Complement Peptides C3a, C4a, and C5a across Vertebrates [PDF]
The Journal of Immunology, 2022 Abstract Complement peptides C3a, C4a, and C5a are important components of innate immunity in vertebrates. Although they diverged from a common ancestor, only C3a and C4a can act as antibacterial peptides in Homo sapiens, suggesting that C5a has evolved into a purely chemotactic molecule; however, the antibacterial properties of C3a, C4a,
Xu‐Jie Zhang +5 more
openalex +4 more sources
Increased activation product of complement 4 protein in plasma of individuals with schizophrenia
Translational Psychiatry, 2021 Structural variation in the complement 4 gene (C4) confers genetic risk for schizophrenia. The variation includes numbers of the increased C4A copy number, which predicts increased C4A mRNA expression.
Agnieszka Kalinowski +14 more
doaj +1 more source
Scientific Reports, 2021 We evaluated changes in the complement system resulting from anti-vascular endothelial growth factor (VEGF) in eyes with age-related choroidal neovascularization (CNV) including neovascular age-related macular degeneration, pachychoroid neovasculopathy ...
Keiichiro Tanaka +13 more
doaj +1 more source
Heterogeneity in the structural basis of the human complement C4A null allele (C4A*Q0) as revealed by HindIII restriction fragment length polymorphism analysis [PDF]
FEBS Letters, 1987 The highly polymorphic fourth component of human complement (C4) is usually encoded by two genes, C4A and C4B, adjacent to the 21‐hydroxylase (21‐OH) genes, 21‐OHA and 21‐OHB, and is also remarkable in the high frequency of the ‘null’ alleles, C4A*Q0 and C4B*Q0.
B. Uring‐Lambert +5 more
openalex +4 more sources
Genome Biology, 2023 Background Increased expression of the complement component 4A (C4A) gene is associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in synaptic pruning; yet, it remains unclear the extent to which upregulation of C4A ...
Leanna M. Hernandez +11 more
doaj +1 more source
Nature Communications, 2022 Schizophrenia risk has been associated with the complement component 4 (C4) genes. Here the authors show that C4A is elevated in individuals with schizophrenia.
Jessica Gracias +31 more
doaj +1 more source
Complement Split Products C3a and C4a in Chronic Lyme Disease [PDF]
Scandinavian Journal of Immunology, 2008 AbstractComplement split products C3a and C4a are reportedly elevated in patients with acute Lyme disease. We have now examined these immunologic markers in patients with chronic Lyme disease compared to appropriate disease controls. The study population consisted of 29 healthy controls, 445 patients with chronic Lyme disease, 11 patients with systemic
R B, Stricker +3 more
openaire +2 more sources
npj Genomic Medicine, 2022 Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk.
Martin Kerick +24 more
doaj +1 more source
Mannan-binding lectin and complement C4A in Icelandic multicase families with systemic lupus erythematosus [PDF]
Annals of the Rheumatic Diseases, 2006 To determine whether low mannan-binding lectin (MBL) and C4A null alleles (C4AQ0) are associated with systemic lupus erythematosus (SLE) in multicase families with SLE.Low MBL level was determined by measuring serum levels and by genotyping for mutant structural (B/C/D, designated as 0) and promoter (LX) alleles (by real-time polymerase chain reaction).
Saedís Saevarsdóttir +5 more
openalex +3 more sources