Genome Biology, 2023 Background Increased expression of the complement component 4A (C4A) gene is associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in synaptic pruning; yet, it remains unclear the extent to which upregulation of C4A ...
Leanna M. Hernandez +11 more
doaj +1 more source
Tear-derived exosomal biomarkers of Graves’ ophthalmopathy
Frontiers in Immunology, 2022 Graves’ ophthalmopathy (GO), the most frequent extrathyroidal manifestation of Graves’ disease (GD), can lead to a significant decline in the quality of life in patients.
Ting-Ting Shi +7 more
doaj +1 more source
Microarray analysis of the effects of Acthar Gel versus methylprednisolone in a model of focal segmental glomerulosclerosis in female rats. [PDF]
Physiol RepEffect of Acthar® Gel versus methylprednisolone on gene expression in a female rat model of focal segmental glomerulosclerosis. Abstract Acthar® Gel (repository corticotropin injection) is an alternative treatment for patients with focal segmental glomerulosclerosis (FSGS) who cannot tolerate or do not adequately respond to glucocorticoids or ...
Hayes K, Wright D.
europepmc +2 more sources
Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases [PDF]
, 2022 Objective Copy number variation of the C4 complement components, C4A and C4B, has been associated with systemic inflammatory autoimmune diseases. This study was undertaken to investigate whether C4 copy number variation is connected to the autoimmune ...
Almlöf, Jonas +42 more
core +1 more source
Nature Communications, 2022 Schizophrenia risk has been associated with the complement component 4 (C4) genes. Here the authors show that C4A is elevated in individuals with schizophrenia.
Jessica Gracias +31 more
doaj +1 more source
Proteomic and In Silico Analyses Highlight Complement System's Role in Bladder Cancer Immune Regulation. [PDF]
Medicina (Kaunas)Background and Objectives: Bladder cancer (BLCA), intimately associated with the immune system, represents a substantial global health burden due to its high recurrence rates and limited therapeutic effectiveness.
Korak T +5 more
europepmc +2 more sources
The isolation and characterization of bovine C4a, an activation fragment of the fourth component of complement [PDF]
Biochemical Journal, 1979 The fourth component of bovine complement, C4, was cleaved specifically by subcomponent C1s to produce two fragments, C4a and C4b. The smaller, C4a, was isolated in pure form and is a peptide of 9500 mol.wt. containing approx. 84 amino acids and no detectable carbohydrate. C4a has an amino acid composition that is comparable with the anaphylatoxins C3a
M A Smith +3 more
openaire +3 more sources
Analysis of complement C4 loci in Caucasoids and Japanese with idiopathic membranous nephropathy [PDF]
, 1992 Analysis of complement C4 loci in Caucasoids and Japanese with idiopathic membranous nephropathy. Deletion of the HLA class III complement gene, C4A, has been linked with susceptibility to a number of autoimmune diseases.
Briggs, David +6 more
core +1 more source
Complement Activation in Patients with Focal Segmental Glomerulosclerosis. [PDF]
PLoS ONE, 2015 Recent pre-clinical studies have shown that complement activation contributes to glomerular and tubular injury in experimental FSGS. Although complement proteins are detected in the glomeruli of some patients with FSGS, it is not known whether this is ...
Joshua M Thurman +12 more
doaj +1 more source
Identification of altered plasma proteins by proteomic study in valvular heart diseases and the potential clinical significance. [PDF]
PLoS ONE, 2013 BackgroundLittle is known about genetic basis and proteomics in valvular heart disease (VHD) including rheumatic (RVD) and degenerative (DVD) valvular disease.
Ge Gao +5 more
doaj +1 more source