Results 51 to 60 of about 675,301 (233)

Complement C4, Infections, and Autoimmune Diseases

Frontiers in Immunology, 2021
Complement C4, a key molecule in the complement system that is one of chief constituents of innate immunity for immediate recognition and elimination of invading microbes, plays an essential role for the functions of both classical (CP) and lectin (LP ...
Hongbin Wang, Hongbin Wang, Hongbin Wang, Mengyao Liu   +3 more
doaj   +1 more source

An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA. [PDF]

, 2015
Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells.
Fishbein, MC, Gjertson, D, Mulder, A, Panicker, S, Parry, GC, Reed, EF, Thomas, KA, Valenzuela, NM   +7 more
core   +1 more source

Opposite Profiles of Complement in Antiphospholipid Syndrome (APS) and Systemic Lupus Erythematosus (SLE) Among Patients With Antiphospholipid Antibodies (aPL)

Frontiers in Immunology, 2019
APS is the association of antiphospholipid antibodies (aPL) with thromboses and/or recurrent pregnancy loss (RPL). Among patients with SLE, one-third have aPL and 10–15% have a manifestation of secondary APS.
Stephanie L. Savelli, Stephanie L. Savelli, Stephanie L. Savelli, Robert A. S. Roubey, Kathryn J. Kitzmiller, Kathryn J. Kitzmiller, Danlei Zhou, Danlei Zhou, Danlei Zhou, Haikady N. Nagaraja, Evan Mulvihill, Evan Mulvihill, Fatima Barbar-Smiley, Fatima Barbar-Smiley, Stacy P. Ardoin, Stacy P. Ardoin, Yee Ling Wu, Yee Ling Wu, Yee Ling Wu, Chack-Yung Yu, Chack-Yung Yu, Chack-Yung Yu   +21 more
doaj   +1 more source

Systemic Alterations of Immune Response-Related Proteins during Glaucoma Development in the Murine Model DBA/2J

Diagnostics, 2020
Animal models of glaucoma, a neurodegenerative disease affecting the retina, offer the opportunity to study candidate molecular biomarkers throughout the disease.
Andrés Fernández-Vega Cueto, Lydia Álvarez, Montserrat García, Enol Artime, Ana Álvarez Barrios, Ignacio Rodríguez-Uña, Miguel Coca-Prados, Héctor González-Iglesias   +7 more
doaj   +1 more source

Determination of Anaphylatoxin Concentrations in Suction Blisters in Patients with Psoriasis [PDF]

, 1986
Concentrations of C3a and C4a anaphylatoxins in suction blister fluids were determined by radioimmunoassay in patients with psoriasis and normal controls.
Ohkohchi, Kyoto, Tagami, Hachiro, Takematsu, Hideaki   +2 more
core   +1 more source

Profiling Complement System Components in Primary CNS Vasculitis

Cells, 2021
Complement activation has been implicated in the pathogenesis of many vasculitic syndromes such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Milani Deb-Chatterji, Christian W. Keller, Simon Koch, Heinz Wiendl, Christian Gerloff, Tim Magnus, Jan D. Lünemann   +6 more
doaj   +1 more source

Polymorphism of the tumor necrosis factor beta gene in systemic lupus erythematosus [PDF]

, 1993
We investigated the Nco I restriction fragment length polymorphism (RFLP) of the tumor necrosis factor beta (TNFB) gene in 173 patients with systemic lupus erythematosus (SLE), 192 unrelated healthy controls, and eleven panel families, all of German ...
Albert, E. D., Bettinotti, M. P., Deicher, H., Hartung, K., Keller, E., Messer, Gerald, Weiss, Elisabeth H.   +6 more
core   +1 more source

Impact of C4, C4A and C4B gene copy number variation in the susceptibility, phenotype and progression of systemic lupus erythematosus

Advances in Rheumatology, 2019
Background Complement component 4 (C4) gene copy number (GCN) affects the susceptibility to systemic lupus erythematosus (SLE) in different populations, however the possible phenotype significance remains to be determined.
Kaline Medeiros Costa Pereira, Sandro Perazzio, Atila Granado A. Faria, Eloisa Sa Moreira, Viviane C. Santos, Marcelle Grecco, Neusa Pereira da Silva, Luis Eduardo Coelho Andrade   +7 more
doaj   +1 more source

Serum proteomic analysis uncovers novel serum biomarkers for depression. [PDF]

Front Psychiatry
ObjectiveThe identification of depression primarily relies on the clinical symptoms and psychiatric evaluation of the patient, in the absence of objective and quantifiable biomarkers within clinical settings.
Guo A, Wang B, Ding J, Zhao L, Wang X, Huang C, Guo B.   +6 more
europepmc   +2 more sources

Correlation of serum levels of complement C4a desArg with pathologically estimated severity of glomerular lesions and mesangial hypercellularity scores in patients with IgA nephropathy.

International Journal of Molecular Medicine, 2013
The aim of the present study was to explore serum biomarkers for the pathology of IgA nephropathy using serum proteomics. The subjects were 57 patients with IgA nephropathy who were divided into two groups (group 1, n=25; group 2, n=32) and 14 healthy ...
A. Sogabe, H. Uto, S. Kanmura, Tsuyoshi Nosaki, M. Oyamada, Koki Tokunaga, Chika Nishida, M. Fukumoto, Manei Oku, Kiichiro Nishimoto, Shozo Takenouchi, A. Ido, Y. Shimada, H. Tsubouchi   +13 more
semanticscholar   +1 more source