Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients. [PDF]
PLoS ONE, 2014 BackgroundNon-tuberculous mycobacteria (NTM) are ubiquitous in the environment and they infect mainly persons with underlying pulmonary diseases but also previously healthy elderly women.
Hannele Kotilainen +9 more
doaj +1 more source
Carriership of a defective tenascin-X gene in steroid 21-hydroxylase deficiency patients: TNXB -TNXA hybrids in apparent large-scale gene conversions [PDF]
, 2002 Steroid 21-hydroxylase deficiency is caused by a defect in the CYP21A2 gene. CYP21A2, the adjacent complement C4 gene and parts of the flanking genes RP1 and TNXB constitute a tandemly duplicated arrangement in the central (class III ...
Degenhart, H.J. (Herman) +2 more
core +2 more sources
Association between copy number variation of complement component
Journal of Biomedical Science, 2011 Background Gene copy number of complement component C4, which varies among individuals, may determine the intrinsic strength of the classical complement pathway.
Liao Wen-Ling +7 more
doaj +1 more source
A serine protease isolated from the bristles of the Amazonic caterpillar, Premolis semirufa, is a potent complement system activator. [PDF]
PLoS ONE, 2015 The caterpillar of the moth Premolis semirufa, commonly named pararama, is found in the Brazilian Amazon region. Accidental contact with the caterpillar bristles causes an intense itching sensation, followed by symptoms of an acute inflammation, which ...
Isadora Maria Villas Boas +5 more
doaj +1 more source
Frontiers in Immunology, 2022 The clinical manifestations of envenomation by Bothrops species are complex and characterized by prominent local effects that can progress to tissue loss, physical disability, or amputation. Systemic signs can also occur, such as hemorrhage, coagulopathy,
Thyago Bispo Leonel +5 more
doaj +1 more source
B\"acklund Transformations of the Sixth Painlev\'e Equation in Terms of Riemann-Hilbert Correspondence [PDF]
, 2003 It is well known that the sixth Painlev\'e equation $\PVI$ admits a group of B\"acklund transformations which is isomorphic to the affine Weyl group of type $\mathrm{D}_4^{(1)}$.
Inaba, Michi-aki +2 more
core +1 more source
VLBA monitoring of Mrk 421 at 15 GHz and 24 GHz during 2011 [PDF]
, 2012 High-resolution radio observations are ideal for constraining the value of physical parameters in the inner regions of active-galactic-nucleus jets and complement results on multiwavelength (MWL) observations. This study is part of a wider multifrequency
A. Marscher +44 more
core +3 more sources
Frontiers in GeneticsIntroduction: Age-related macular degeneration (AMD) is the leading cause of central vision loss in the elderly. One-third of the genetic contribution to this disease remains unexplained.Methods: We analyzed targeted sequencing data from two independent ...
Johanna M. Seddon +9 more
doaj +1 more source
Plasma protein biomarkers of hepatocellular carcinoma in HCV-infected alcoholic patients with cirrhosis. [PDF]
PLoS ONE, 2015 Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers in the world, with limited options for treatment unless timely diagnosed. Chronic hepatitis C virus (HCV) infection and persistent heavy alcohol consumption are independent risk ...
Gustavo Ferrín +11 more
doaj +1 more source
Changes in Expression of Complement Components in the Ovine Spleen during Early Pregnancy
Animals, 2021 During early gestation in humans, complement regulation is essential for normal fetal growth. It is supposed that a complement pathway participates in maternal splenic immune regulation at the early stage of gestation in ewes.
Ling Yang +5 more
doaj +1 more source