Results 61 to 70 of about 6,275 (172)

Complete Complement Components C4A and C4B Deficiencies in Human Kidney Diseases and Systemic Lupus Erythematosus [PDF]

The Journal of Immunology, 2004
Abstract Although a heterozygous deficiency of either complement component C4A or C4B is common, and each has a frequency of ∼20% in a Caucasian population, complete deficiencies of both C4A and C4B proteins are extremely rare. In this paper the clinical courses for seven complete C4 deficiency patients are described in detail, and the ...
Yang, Yan, Lhotta, Karl, Chung, Erwin K., Eder, Paula, Neumair, Friedrich, Yu, C. Yung   +5 more
openaire   +3 more sources

Tolerability and Feasibility of Minimally Invasive Canine Skin Sampling: Excellent Tolerability Meets Transcriptomic Challenges

Veterinary Dermatology, EarlyView.
ABSTRACT Background Advances in transcriptomics have driven the demand for minimally invasive, reproducible and high‐yield skin sampling methods, particularly for studying inflammatory skin diseases in companion animals. Hypothesis/Objectives We tested tolerability, feasibility and RNA quantity and quality of three minimally invasive skin sampling ...
Ina Herrmann, Lisa B. Mamo, Allison N. Dickey   +2 more
wiley   +1 more source

Hyaluronic Acid Decoration Facilitates CD44‐Mediated Targeting and Alters Protein Corona Formation of Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Cell recognition and uptake of extracellular vesicles (EVs) is mediated by a variety of surface molecules. Growing interest has recently been drawn towards glycan structures on EVs. Hyaluronic acid (HA) is a negatively charged glycosaminoglycan that can decorate the surface of EVs from different origins.
Heikki Kyykallio, Elena Scurti, Martina Hanzlíková, Kirsti Härkönen, Tuovi Salo, Veera Keinonen, Janne Capra, Tapani Viitala, Jaakko Teppo, Tatu Lajunen, Kirsi Rilla   +10 more
wiley   +1 more source

Natural antibodies and CRP drive anaphylatoxin production by urate crystals

Scientific Reports, 2022
In gout, crystallization of uric acid in the form of monosodium urate (MSU) leads to a painful inflammatory response. MSU crystals induce inflammation by activating the complement system and various immune cell types, and by inducing necrotic cell death.
Anne Kathrin Wessig, Leonie Hoffmeister, Annika Klingberg, Anika Alberts, Andreas Pich, Korbinian Brand, Torsten Witte, Konstantin Neumann   +7 more
doaj   +1 more source

Machine Learning Model for an App‐Based Tool to Assist With the Diagnosis of Canine Atopic Dermatitis

Veterinary Dermatology, Volume 37, Issue 2, Page 236-246, April 2026.
Canine atopic dermatitis (cAD) is a chronic condition requiring life‐long management. Accurate diagnosis can be challenging, with no reliable diagnostic test. This study aimed to generate a simple diagnostic model for cAD. This model is a relevant prototype for an app‐based tool to support general practitioners in the diagnosis of cAD alongside ...
Xavier Langon, Mathieu Montoya, Isabelle Gourdon   +2 more
wiley   +1 more source

Serum proteomic analysis uncovers novel serum biomarkers for depression

Frontiers in Psychiatry
ObjectiveThe identification of depression primarily relies on the clinical symptoms and psychiatric evaluation of the patient, in the absence of objective and quantifiable biomarkers within clinical settings.
Aihong Guo, Aihong Guo, Bingju Wang, Bingju Wang, Bingju Wang, Jiangbo Ding, Jiangbo Ding, Lihong Zhao, Xiaofei Wang, Chen Huang, Chen Huang, Bo Guo, Bo Guo   +12 more
doaj   +1 more source

Associação do alótipo raro C4A6 do sistema complemento com a doença cardíaca reumática Association of the C4A6 rare allotype with rheumatic heart disease

Revista Brasileira de Reumatologia, 2004
OBJETIVO: determinar se os alótipos do Fator B (BF), C2 e C4 (C4A e C4B) do sistema complemento poderiam ser marcadores para a doença cardíaca reumática (DCR) na população brasileira. MÉTODOS: foram estudados 49 pacientes com DCR crônica.
Iara Jose de Messias-Reason, Ednéia Cavalcanti, Sebastião Cézar Radominski   +2 more
doaj   +1 more source

Reducing data processing effort in camera trap density estimation: Extending the REST model by explicitly modelling animal detection processes

Methods in Ecology and Evolution, Volume 17, Issue 3, Page 850-862, March 2026.
Abstract Accurate and reliable estimation of wildlife population density is fundamental to effective conservation and management. While camera traps show potential for monitoring ground‐dwelling mammal densities, labour‐intensive data processing remains a significant constraint. Ideally, conservation efforts would benefit from the continuous monitoring
Yoshihiro Nakashima, Gota Yajima, Ryo Matsuoka   +2 more
wiley   +1 more source

Heterogeneity of iridoid biosynthesis in catmints: Molecular background in a phylogenetic context

Journal of Integrative Plant Biology, Volume 68, Issue 3, Page 694-718, March 2026.
Evolutionary gains and losses of key biosynthetic genes likely resulting from multiple independent evolutionary events explain why certain Nepeta (catnip) species produce both the active, cat‐attracting nepetalactones and sugar‐bound iridoids, while others make only the sugar‐bound forms, and some have lost iridoid production entirely.
Tijana Banjanac, Milica Milutinović, Dragana Matekalo, Neda Popović, Luka Petrović, Uroš Gašić, Marijana Skorić, Branislav Šiler, Tamara Lukić, Ana Stupar, Slavica Dmitrović, Jasmina Nestorović Živković, Biljana Filipović, Jelena Božunović, Miloš Todorović, Danijela Mišić   +15 more
wiley   +1 more source

Sample processing time but not storage time affects complement activation markers C4a, C4d, C3a, iC3b, Bb, C5a, and sC5b-9 levels in EDTA-plasma of individuals at clinical high-risk for psychosis

Biomarkers in Neuropsychiatry
The complement system is an important part of the innate immune system and plays a key role in inflammatory processes. Concentrations of complement activation fragments in plasma are markers of systemic activation and have been found to be altered in a ...
Eleftheria Kodosaki, Colm Healy, Jonah F. Byrne, Melanie Föcking, Mary Cannon, Diana O. Perkins, David Cotter, Meike Heurich   +7 more
doaj   +1 more source