Results 71 to 80 of about 675,301 (233)

VLBA monitoring of Mrk 421 at 15 GHz and 24 GHz during 2011 [PDF]

, 2012
High-resolution radio observations are ideal for constraining the value of physical parameters in the inner regions of active-galactic-nucleus jets and complement results on multiwavelength (MWL) observations. This study is part of a wider multifrequency
A. Marscher, Abdo, Chiaberge, Cornwell, D. Paneque, Deller, G. Giovannini, G. Piner, Gaidos, Georganopoulos, Ghisellini, Giovannini, Giroletti, Giroletti, Giroletti, Greisen, Henri, Hovatta, Högbom, K. V. Sokolovsky, L. Fuhrmann, Lister, Lyutikov, M. A. Perez-Torres, M. Giroletti, M. Kino, M. Orienti, Marscher, Orienti, P. G. Edwards, Piner, Piner, Piner, Piner, Piner, Punch, R. Lico, Readhead, S. Jorstad, Shepherd, T. P. Krichbaum, Tavecchio, Tingay, W. Cotton, Y. Y. Kovalev   +44 more
core   +3 more sources

Subunits of C1Q Are Associated With the Progression of Intermittent Claudication to Chronic Limb-Threatening Ischemia

Frontiers in Cardiovascular Medicine, 2022
BackgroundThe pathophysiological mechanisms of intermittent claudication (IC) progression to chronic limb-threatening ischemia (CLTI) are still vague and which of patients with IC will become CLTI are unknown.
Ziping Yao, Bihui Zhang, Guochen Niu, Ziguang Yan, Xiaoqiang Tong, Yinghua Zou, Min Yang   +6 more
doaj   +1 more source

Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics

Annals of Neurology, EarlyView.
Objectives Rapid advances in transcriptomics have driven efforts to identify deregulated pathways in multiple sclerosis (MS) tissues, though many detected differentially expressed genes are likely false positives, with only a small fraction reflecting actual pathological events. Robust, integrative methods are essential for accurately understanding the
Gianmarco Abbadessa, Ai Nagano, Simon Hametner, Owain Howell, David Owen, Artemis Papadaki, Prashant Srivastava, Simona Bonavita, Roberta Magliozzi, Richard Reynolds, Mie Rizig, Richard Nicholas   +11 more
wiley   +1 more source

Deregulation of complement components C4A and CSMD1 peripheral expression in first-episode psychosis and links to cognitive ability

European Archives of Psychiatry and Clinical Neuroscience, 2022
Up-regulation of the complement component 4A (C4A) in the brain has been associated with excessive synaptic pruning and increased schizophrenia (SZ) susceptibility.
A. Hatzimanolis, S. Foteli, P. Stefanatou, Angeliki-Aikaterini Ntigrintaki, I. Ralli, K. Kollias, C. Nikolaou, M. Gazouli, N. Stefanis   +8 more
semanticscholar   +1 more source

Rotenoids from the Roots of Vicia faba L. (Fabaceae): Structural Characterization, Cytotoxic Effects, and Molecular Docking

Chemistry &Biodiversity, EarlyView.
ABSTRACT The chemical study of the ethanolic extract from the roots of Vicia faba led to the isolation of two isoflavonoids, alfalone and 8‐O‐methylretusine, as well as a mixture of rotenoids, including clitoriacetal and clitoriacetal B, the latter of which is reported for the first time.
Victor Menezes Sipoloni, João Victor Silva‐Silva, Elthon G. Ferreira, Eric Yoshitaka Lee, João Marcos Batista Junior, Miriam Uemi, Lívia Soman de Medeiros, Paula C. Jimenez, Thiago A. M. Veiga   +8 more
wiley   +1 more source

Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide [PDF]

, 2015
Infection with noncytopathic bovine viral diarrhea virus (ncpBVDV) is associated with uterine disease and infertility. This study investigated the influence of ncpBVDV on immune functions of the bovine endometrium by testing the response to bacterial ...
Abudureyimu, A, Anstaett, O L, Brownlie, J, Cheng, Z R, Fouladi-Nashta, A A, Oguejiofor, C F, Wathes, D C   +6 more
core   +1 more source

Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma

Frontiers in Endocrinology, 2021
BackgroundEarly diagnosis and therapy of papillary thyroid carcinoma (PTC) is essential for reducing recurrence and improving the long-term survival. In this study, we aimed to investigate the proteome profile of plasma and screen unique proteins which ...
Yichao Wang, Yichao Wang, Shengliang Zhou, Shengliang Zhou, Shengliang Zhou, Dun Wang, Dun Wang, Dun Wang, Tao Wei, Tao Wei, Jingqiang Zhu, Jingqiang Zhu, Zhihui Li   +12 more
doaj   +1 more source

The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]

, 2018
The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J, Graves, Edward E, Kim, Ryan K, Melemenidis, Stavros, Olcina, Monica M   +4 more
core   +1 more source

Fisetin as a Blueprint for Senotherapeutic Agents – Elucidating Geroprotective and Senolytic Properties with Molecular Modeling

Chemistry – A European Journal, Volume 31, Issue 16, March 17, 2025.
The exceptional senotherapeutic activity of fisetin, combining both geroprotective and senolytic effects, was validated using computational chemistry tools, establishing it as a cornerstone template for the development of novel agents. Abstract Targeting senescent cells and the factors that accelerate this pathological state has recently emerged as a ...
Maciej Spiegel
wiley   +1 more source

C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera

Frontiers in Immunology, 2021
Systemic complement activation drives a plethora of pathological conditions, but its role in snake envenoming remains obscure. Here, we explored complement’s contribution to the physiopathogenesis of Naja annulifera envenomation.
Felipe Silva de França, Isadora Maria Villas-Boas, Bruno Cogliati, Trent M. Woodruff, Edimara da Silva Reis, John D. Lambris, Denise V. Tambourgi   +6 more
doaj   +1 more source