Results 71 to 80 of about 6,275 (172)

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

Association Study of the Complement Component C4 Gene in Tardive Dyskinesia

Frontiers in Pharmacology, 2019
Tardive dyskinesia (TD) is a movement disorder that may develop in schizophrenia patients being treated long-term with antipsychotic medication. TD interferes with voluntary movements and leads to stigma, and can be associated with treatment non ...
Clement C. Zai, Clement C. Zai, Clement C. Zai, Clement C. Zai, Arun K. Tiwari, Arun K. Tiwari, Gwyneth C. Zai, Gwyneth C. Zai, Gwyneth C. Zai, Natalie Freeman, Jennie G. Pouget, Jennie G. Pouget, James Greco, Maria Tampakeras, Sajid A. Shaikh, Deanna Herbert, Heather Emmerson, Sheraz Y. Cheema, Nicole Braganza, Daniel J. Müller, Daniel J. Müller, Daniel J. Müller, Aristotle N. Voineskos, Aristotle N. Voineskos, Aristotle N. Voineskos, Gary Remington, Gary Remington, Gary Remington, James L. Kennedy, James L. Kennedy, James L. Kennedy   +30 more
doaj   +1 more source

Detection of both isotypes of complement C4, C4A and C4B, in normal human glomeruli

Kidney International, 1986
Monoclonal antibodies reactive against the complement C4A and C4B isotypic components were used in an immunoperoxidase technique for the histological study of normal human renal tissue. Prominent staining with both antibodies was seen in the mesangial areas of all normal kidney sections investigated.
Feucht, Helmut E., Jung, Christina M., Gokel, Michael J., Riethmüller, Gert, Zwirner, Jörg, Brase, Angelika, Held, Eckhard, O'Neill, Geoffrey J.   +7 more
openaire   +2 more sources

Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice. [PDF]

Nat Neurosci, 2021
Yilmaz M, Yalcin E, Presumey J, Aw E, Ma M, Whelan CW, Stevens B, McCarroll SA, Carroll MC.   +8 more
europepmc   +1 more source

Complement system in dermatological diseases – fire under the skin

Frontiers in Medicine, 2015
The complement system plays a key role in several dermatological diseases. Overactivation, deficiency or abnormality of the control proteins are often related to a skin disease.
Jaana Helena Panelius, Jaana Helena Panelius, Seppo Kalevi Meri, Seppo Kalevi Meri, Seppo Kalevi Meri   +4 more
doaj   +1 more source

MALDI-TOF-MS Analysis in the Identification of Urine Proteomic Patterns of Gestational Trophoblastic Disease

Metabolites, 2019
Gestational trophoblastic disease (GTD) is a group of highly aggressive, rare tumors. Human chorionic gonadotropin is a common biomarker used in the diagnosis and monitoring of GTD.
Paulina Banach, Paweł Dereziński, Eliza Matuszewska, Jan Matysiak, Hubert Bochyński, Zenon J. Kokot, Ewa Nowak-Markwitz   +6 more
doaj   +1 more source

Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes

Nature Communications
Progressive supranuclear palsy (PSP), a rare Parkinsonian disorder, is characterized by problems with movement, balance, and cognition. PSP differs from Alzheimer’s disease (AD) and other diseases, displaying abnormal microtubule-associated protein tau ...
Kurt Farrell, Jack Humphrey, Timothy Chang, Yi Zhao, Yuk Yee Leung, Pavel P. Kuksa, Vishakha Patil, Wan-Ping Lee, Amanda B. Kuzma, Otto Valladares, Laura B. Cantwell, Hui Wang, Ashvin Ravi, Claudia De Sanctis, Natalia Han, Thomas D. Christie, Robina Afzal, Shrishtee Kandoi, Kristen Whitney, Margaret M. Krassner, Hadley Ressler, SoongHo Kim, Diana Dangoor, Megan A. Iida, Alicia Casella, Ruth H. Walker, Melissa J. Nirenberg, Alan E. Renton, Bergan Babrowicz, Giovanni Coppola, Towfique Raj, Günter U. Höglinger, Ulrich Müller, Lawrence I. Golbe, Huw R. Morris, John Hardy, Tamas Revesz, Tom T. Warner, Zane Jaunmuktane, Kin Y. Mok, Rosa Rademakers, Dennis W. Dickson, Owen A. Ross, Li-San Wang, Alison Goate, Gerard Schellenberg, Daniel H. Geschwind, PSP Genetics Study Group, John F. Crary, Adam Naj   +49 more
doaj   +1 more source

VISUAL PATTERNS OF С4А AND C4B SUBISOTYPES OF C4 COMPONENT OF HUMAN COMPLEMENT SYSTEM IN THE DIAGNOSTICS OF AUTOIMMUNE AND INFECTIOUS DISEASES

Acta Biomedica Scientifica, 2015
Results on visual patterns of subisotypes of patient sera complement component C4 complexes separated by isoelectric focusing in polyacrylamide gel and eiectrobiotting are presented.
M. V. Lakhtin, V. M. Lakhtin, S. S. Afanasiev, V. A. Aleshkin   +3 more
doaj  

Complement C4a Measurement [PDF]

, 2020
openaire   +1 more source

Autoantibodies reactive with glomerular endothelial cells and podocytes in patients with membranous nephropathy. [PDF]

J Transl Autoimmun
Petr V, Purohit S, Poppelaars F, Renner B, Laskowski J, Whelan R, Kulik L, Kendrick J, Frazer-Abel A, Jalal D, Marcolin B, Schmelzer I, Debiec H, Ronco P, Saleem MA, Satchell SC, Thurman JM.   +16 more
europepmc   +1 more source