Results 81 to 90 of about 11,949 (217)

HIV induces expression of complement component C3 in astrocytes by NF-κB-dependent activation of interleukin-6 synthesis [PDF]

, 2017
Background Abnormal activation of the complement system contributes to some central nervous system diseases but the role of complement in HIV-associated neurocognitive disorder (HAND) is unclear.
Borjabad, Alejandra, Chao, Wei, Emdad, Luni, Fisher, Paul B., Morgello, Susan, Murray, Jacinta, Nitkiewicz, Jadwiga, Potash, Mary Jane, Volsky, David J.   +8 more
core   +2 more sources

The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]

, 2018
The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J, Graves, Edward E, Kim, Ryan K, Melemenidis, Stavros, Olcina, Monica M   +4 more
core   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Complement activation and regulation in preeclamptic placenta

Frontiers in Immunology, 2014
Preeclampsia (PE) is a common disorder of pregnancy originating in the placenta. We examined whether excessive activation or poor regulation of the complement system at the maternal-fetal interface could contribute to the development of PE.
A. Inkeri eLokki, A. Inkeri eLokki, A. Inkeri eLokki, Jenni eHeikkinen-Eloranta, Jenni eHeikkinen-Eloranta, Hanna eJarva, Hanna eJarva, Hanna eJarva, Terhi eSaisto, Marja-Liisa eLokki, Hannele eLaivuori, Hannele eLaivuori, Seppo eMeri, Seppo eMeri, Seppo eMeri   +14 more
doaj   +1 more source

Complement C4-A and Plasminogen as Potential Biomarkers for Prediction of Papillary Thyroid Carcinoma

Frontiers in Endocrinology, 2021
BackgroundEarly diagnosis and therapy of papillary thyroid carcinoma (PTC) is essential for reducing recurrence and improving the long-term survival. In this study, we aimed to investigate the proteome profile of plasma and screen unique proteins which ...
Yichao Wang, Yichao Wang, Shengliang Zhou, Shengliang Zhou, Shengliang Zhou, Dun Wang, Dun Wang, Dun Wang, Tao Wei, Tao Wei, Jingqiang Zhu, Jingqiang Zhu, Zhihui Li   +12 more
doaj   +1 more source

Problems on electrorheological fluid flows

, 2003
We develop a model of an electrorheological fluid such that the fluid is considered as an anisotropic one with the viscosity depending on the second invariant of the rate of strain tensor, on the module of the vector of electric field strength, and on ...
Hoppe, R. H. W., Litvinov, W. G.
core   +1 more source

Huntington's disease: An immune perspective [PDF]

, 2011
Copyright © 2011 Annapurna Nayaketal. This article has been made available through the Brunel Open Access Publishing Fund.Huntington's disease (HD) is a progressive neurodegenerative disorder that is caused by abnormal expansion of CAG trinucleotide ...
Ansar, R, Bonifati, DM, Kishore, U, Nayak, A, Verma, SK   +4 more
core   +3 more sources

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Complement activation by heparin-protamine complexes during cardiopulmonary bypass: Effect of C4A null allele [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 1997
The first objective was to determine the effect of inherited differences in the classic pathway complement protein C4 on complement activation by heparin-protamine complexes in cardiac surgery. Specifically, we hypothesized that patients with heterozygous C4A null phenotype (A0BB), who have decreased amounts of C4A, may have increased complement ...
Shastri, Kaushik A., Logue, Gerald L., Stern, Mont P., Rehman, Saif, Raza, Syed   +4 more
openaire   +2 more sources

C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera

Frontiers in Immunology, 2021
Systemic complement activation drives a plethora of pathological conditions, but its role in snake envenoming remains obscure. Here, we explored complement’s contribution to the physiopathogenesis of Naja annulifera envenomation.
Felipe Silva de França, Isadora Maria Villas-Boas, Bruno Cogliati, Trent M. Woodruff, Edimara da Silva Reis, John D. Lambris, Denise V. Tambourgi   +6 more
doaj   +1 more source