Results 101 to 110 of about 712,823 (260)

Structural Model for Factor X Inhibition of IgM and Complement-Mediated Neutralization of Adenovirus

Viruses, 2023
Adenovirus has strong therapeutic potential as an oncolytic virus and gene therapy vector. However, injecting human species C serotype 5 adenovirus, HAdv-C5, into the bloodstream leads to numerous interactions with plasma proteins that affect viral ...
Nicole Wagner, Dmitry M. Shayakhmetov, Phoebe L. Stewart   +2 more
doaj   +1 more source

Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy, Enzo Scifo, Kan Xie, Kristina Schaaf, Jenny Russ, Stefan Paulusch, Elena De Domenico, Paolo Salomoni, Daniele Bano, Dan Ehninger   +9 more
wiley   +1 more source

How Escherichia coli Circumvent Complement-Mediated Killing

Frontiers in Immunology, 2017
Complement is a crucial arm of the innate immune response against invading bacterial pathogens, and one of its main functions is to recognize and destroy target cells.
Angela S. Barbosa, Afonso G. Abreu, Afonso G. Abreu   +2 more
doaj   +1 more source

Proteomic analysis of small extracellular vesicles from the plasma of patients with hepatocellular carcinoma

World Journal of Surgical Oncology, 2022
Purpose Liver cancer is one of the most common tumors with the seventh-highest incidence and the third-highest mortality. Many studies have shown that small extracellular vesicles (sEVs) play an important role in liver cancer.
Wei Dong, Zeyu Xia, Zehua Chai, Zhidong Qiu, Xuehong Wang, Zebin Yang, Junnan Wang, Tingrui Zhang, Qinqin Zhang, Junfei Jin   +9 more
doaj   +1 more source

Mapping of the Epstein-Barr virus and C3dg binding sites to a common domain on complement receptor type 2. [PDF]

, 1989
Complement receptor type 2 (CR2;CD21), a member of the superfamily of proteins containing short consensus repeats (SCRs), is the B cell receptor for both the gp350/220 envelope protein of Epstein-Barr virus (EBV), and for the C3dg protein of complement ...
Ahearn, JM, Carter, RH, Fearon, DT, Klickstein, LB, Lowell, CA, Mitchell, JA   +5 more
core  

Innate immunity and neuroinflammation [PDF]

, 2013
Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
core   +3 more sources

Emerging methods for subtype differentiation in primary aldosteronism

Journal of Internal Medicine, Volume 299, Issue 2, Page 178-195, February 2026.
Abstract Primary aldosteronism (PA) is a common cause of hypertension. Compared to patients with essential hypertension, untreated PA is associated with a two‐ to fourfold greater risk of cardiovascular disease, renal failure, and death. PA is caused by increased secretion of aldosterone from one adrenal gland in 30% of the patients and both adrenal ...
Oskar Ragnarsson, C. Christofer Juhlin, Tobias Åkerström, Per Dahlqvist, Henrik Falhammar, Per Hellman   +5 more
wiley   +1 more source

Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b. [PDF]

Proceedings of the National Academy of Sciences, 1983
C4b-binding protein (C4bp) participates in the regulation of the C3 convertase of the classical pathway of complement. By binding to C4b, which is one of the structural subunits of this enzyme, C4bp accelerates the decay-dissociation of the enzyme and renders C4b susceptible to degradation by factor I (C3b inactivator).
B, Dahlbäck, C A, Smith, H J, Müller-Eberhard   +2 more
openaire   +2 more sources

Gut proteome and microbiome alterations: Analysis of transverse colon samples from pathologically confirmed Alzheimer's disease patients

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) has been regarded as a brain‐first disorder. Emerging evidence suggests that the gut may influence central nervous system pathology, but the mechanisms remain unclear. METHODS We conducted a proteomic and microbial analysis of transverse colon samples from clinically and pathologically confirmed AD and ...
Qiwen Cheng, Jennifer Nolz, Timothy Karr, Nicole Dorn, Benjamin Readhead, Rosa Krajmalnik‐Brown, Diego Mastroeni   +6 more
wiley   +1 more source

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients. [PDF]

PLoS ONE, 2014
BackgroundNon-tuberculous mycobacteria (NTM) are ubiquitous in the environment and they infect mainly persons with underlying pulmonary diseases but also previously healthy elderly women.
Hannele Kotilainen, Marja-Liisa Lokki, Riitta Paakkanen, Mikko Seppänen, Pentti Tukiainen, Seppo Meri, Tuija Poussa, Jussi Eskola, Ville Valtonen, Asko Järvinen   +9 more
doaj   +1 more source