Results 101 to 110 of about 697,969 (251)

Impact of Strongyloides stercoralis infection on complement activation in Type 2 diabetes mellitus: Insights from a clinical and anthelmintic intervention study.

PLoS Neglected Tropical Diseases
BackgroundNumerous studies indicate a potential protective role of helminths in diabetes mellitus (DM) progression. The complement system, vital for host defense, plays a crucial role in tissue homeostasis and immune surveillance. Dysregulated complement
Anuradha Rajamanickam, Bindu Dasan, Saravanan Munisankar, Sujatha Nott, Pradeep A Menon, Fayaz Ahamed Shaik, Ponnuraja Chinnaiyan, Thomas B Nutman, Subash Babu   +8 more
doaj   +1 more source

Immunometabolism of Liver Xenotransplantation and Prospective Solutions

Advanced Science, Volume 12, Issue 9, March 6, 2025.
After xenotransplantation, pig livers will replace those of human patients to maintain the stability of metabolism and immune system. The incompatibility of immunometabolism between humans and pigs induces rejection, inflammation, coagulation dysfunction, and liver failure. The profile of immunometabolism pre‐transplantation and post‐transplantation is
Shoulong Deng, Yi Zhang, Shasha Shen, Chongyang Li, Chuan Qin   +4 more
wiley   +1 more source

Classifying complements for conformal algebras [PDF]

arXiv, 2020
Let $R\subseteq E$ be two Lie conformal algebras and $Q$ be a given complement of $R$ in $E$. Classifying complements problem asks for describing and classifying all complements of $R$ in $E$ up to an isomorphism. It is known that $E$ is isomorphic to a bicrossed product of $R$ and $Q$.
arxiv  

Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria.

PLoS ONE, 2012
Complement receptor-type 1 (CR1, CD35) is the immune-adherence receptor, a complement regulator, and an erythroid receptor for Plasmodium falciparum during merozoite invasion and subsequent rosette formation involving parasitized and non-infected ...
Patience B Tetteh-Quarcoo, Christoph Q Schmidt, Wai-Hong Tham, Richard Hauhart, Haydyn D T Mertens, Arthur Rowe, John P Atkinson, Alan F Cowman, J Alexandra Rowe, Paul N Barlow   +9 more
doaj   +1 more source

Systematic review and meta‐analysis of bulk RNAseq studies in human Alzheimer's disease brain tissue

Alzheimer's &Dementia, Volume 21, Issue 3, March 2025.
Abstract We systematically reviewed and meta‐analyzed bulk RNA sequencing (RNAseq) studies comparing Alzheimer's disease (AD) patients to controls in human brain tissue. We searched PubMed, Web of Science, and Scopus for human brain bulk RNAseq studies, excluding re‐analyses and studies limited to small RNAs or gene panels. We developed 10 criteria for
Bernardo Aguzzoli Heberle, Kristin L. Fox, Lucas Lobraico Libermann, Sophia Ronchetti Martins Xavier, Guilherme Tarnowski Dallarosa, Rhaná Carolina Santos, David W. Fardo, Thiago Wendt Viola, Mark T. W. Ebbert   +8 more
wiley   +1 more source

Multi Layered Omics Approaches Reveal Glia Specific Alterations in Alzheimer's Disease: A Systematic Review and Future Prospects

Glia, Volume 73, Issue 3, Page 539-573, March 2025.
Main Point Graphical overview of the literature summarized in this review, spanning glia cells and levels of omics analysis present on Alzheimer's disease. ABSTRACT Alzheimer's disease (AD) is the most common neurodegenerative dementia with multi‐layered complexity in its molecular etiology.
Özkan İş, Yuhao Min, Xue Wang, Stephanie R. Oatman, Ann Abraham Daniel, Nilüfer Ertekin‐Taner   +5 more
wiley   +1 more source

Proteomic Analyses of Clots Identify Stroke Etiologies in Patients Undergoing Endovascular Therapy

CNS Neuroscience &Therapeutics, Volume 31, Issue 3, March 2025.
We successfully identified specific biomarkers associated with stroke mechanisms. We developed a methodology that enabled the identification of biomarkers for different stroke subtypes, such as cardioembolism, large artery atherosclerosis, and cancer‐related, through proteomic analysis.
Tae Jung Kim, Jin Woo Jung, Young‐Ju Kim, Byung‐Woo Yoon, Dohyun Han, Sang‐Bae Ko   +5 more
wiley   +1 more source

Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival

Cellular Microbiology, 2017
Borrelia burgdorferi (Bb) is the causative agent of Lyme disease in the United States, a disease that can result in carditis, and chronic and debilitating arthritis and/or neurologic symptoms if left untreated.
Jennifer A Caine, Yi-Pin Lin, Julie R Kessler, Hiromi Sato, J. Leong, J. Coburn   +5 more
semanticscholar   +1 more source

Pentraxins in Complement Activation and Regulation

Frontiers in Immunology, 2018
The complement is the first line of immune defense system involved in elimination of invading pathogens and dying host cells. Its activation is mainly triggered by immune complexes or pattern recognition molecules (PRMs) upon recognition against non-self
Ying Jie Ma, Peter Garred
doaj   +1 more source

Association between copy number variation of complement component C4 and Graves' disease

Journal of Biomedical Science, 2011
Background Gene copy number of complement component C4, which varies among individuals, may determine the intrinsic strength of the classical complement pathway.
Liao Wen-Ling, Chang Chwen-Tzuei, Wan Lei, Liu Yu-Huei, Chen Wen-Chi, Tsai Yuhsin, Tsai Chang-Hai, Tsai Fuu-Jen   +7 more
doaj   +1 more source