Results 91 to 100 of about 1,060,485 (284)

Complement C5 inhibitor: revolutionizing treatment for refractory anti-acetylcholine receptor antibody positive generalized myasthenia gravis [PDF]

Journal of Neurocritical Care
Background Recently, increasing evidence has demonstrated the rapid beneficial effect of monoclonal antibodies blocking the terminal complement protein C5 in refractory generalized myasthenia gravis (gMG); therefore, they have emerged as a promising ...
Kit Mun Loke, Fu Liong Hiew
doaj   +1 more source

Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation

, 2017
Eculizumab inhibits the terminal, lytic pathway of complement by blocking the activation of the complement protein C5 and shows remarkable clinical benefits in certain complement-mediated diseases.
Christoph Q. Schmidt, Lambris, John D., Inge von Zabern, Höchsmann, Britta, Nadine Kuhn, Christof Weinstock, Weinstock, Christof, Markus J. Harder, Skerra, Arne, Arne Skerra, John D. Lambris, Thomas Simmet, Anliker, Markus, Daniel Ricklin, Schmidt, Christoph Q., Schrezenmeier, Hubert, Hubert Schrezenmeier, Markus Anliker, Simmet, Thomas, Ricklin, Daniel, Britta Höchsmann, Harder, Markus J., Kuhn, Nadine, von Zabern, Inge   +23 more
core   +1 more source

Symbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus Complex

Advanced Science, EarlyView.
In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun   +8 more
wiley   +1 more source

Complement C2 receptor inhibitor trispanning: a novel human complement inhibitory receptor

, 2005
The complement system presents a powerful defense against infection and is tightly regulated to prevent damage to self by functionally equivalent soluble and membrane regulators.
Krueger, G., Lange, S., Hui Kwok-M, Schneider, B., Inal, J., Miot, S., Ramirez, M.   +6 more
core  

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

Complement C5 Contributes to Brain Injury After Subarachnoid Hemorrhage [PDF]

, 2020
Previous studies showed that complement activation is associated with poor functional outcome after aneurysmal subarachnoid hemorrhage (SAH). We investigated whether complement activation is underlying brain injury after aneurysmal SAH (n = 7) and if it ...
Brouwer, Matthijs, Rinkel, G. J. E., Meijers, Joost C. M., van Dijk, Bart J., Kloek, Anne T., van der Kamp, Marije J., van de Beek, Diederik, Knaup, V. L., Osuka, Koji, Hol, Elly M., Vergouwen, Mervyn D I, van de Beek, D., Morgan, B. Paul, Kloek, Anne T, Ruigrok, Ynte M., Meijers, Joost C.M., Rinkel, Gabriel J. E., Morgan, B. P., Meijers, J. C. M., Hol, E. M., Vergouwen, M. D. I., Rinkel, Gabriel J.E., van der Kamp, Marije J, Pekna, Marcela, van Dijk, B. J., Knaup, Veronique L, Vergouwen, Mervyn D. I., Aronica, E., Aronica, Eleonora, Vergouwen, Mervyn D.I., van der Kamp, M. J., Ruigrok, Ynte M, Pekna, Marcela,, van Dijk, Bart J, Kloek, A. T., Brouwer, M., Morgan, B Paul, Rinkel, Gabriel J E, Hol, Elly M, Meijers, Joost C M, Osuka, K., Knaup, Veronique L., Ruigrok, Y. M.   +42 more
core   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Case report: persistent anemia after eculizumab in paroxysmal nocturnal hemoglobinuria: non-dominantly active intravascular hemolysis

Hematology
Objectives Paroxysmal nocturnal hemoglobinuria (PNH) is a rare condition characterized by intravascular hemolysis (IVH), thrombosis, and organ damage.
Baozhi Fang, Xiao Yu, Yifei Zhou, Qiudan Shen, Muzhi Yuan, Peng Wang, Mingen Lü, Guangsheng He   +7 more
doaj   +1 more source

Tissue-Type Plasminogen Activator and Tenecteplase-Mediated Increase in Blood Brain Barrier Permeability Involves Cell Intrinsic Complement

Frontiers in Neurology, 2020
Background: Tissue-type plasminogen activator (t-PA) has been the mainstay of therapeutic thrombolysis for patients with acute ischaemic stroke (AIS). However, t-PA can cause devastating intracerebral hemorrhage.
Charithani B. Keragala, Trent M. Woodruff, Zikou Liu, Be'eri Niego, Heidi Ho, Zoe McQuilten, Robert L. Medcalf   +6 more
doaj   +1 more source

Structure and influence of tick complement inhibitor on human complement component 5

, 2008
To provide insight into the structural and functional properties of human complement component 5 (C5), we determined its crystal structure at a resolution of 3.1 Å.
Pietro Roversi, Lars Sottrup-Jensen, Nunn, MA, Folmer Fredslund, Laursen, Nick S., Pedersen, Jan S., Susan M Lea, Andersen, Gregers R., Jenner, Lasse, Lea, Susan M., Laursen, NS, Lasse Jenner, Jan S Pedersen, Miles A Nunn, Jenner, L, Sottrup-Jensen, Lars, Lea, Susan, Richard Discipio, Oliveira, CLP, Nunn, Miles A., Fredslund, F, Pedersen, JS, Discipio, R, Nick S Laursen, Fredslund, Folmer, Oliveira, Cristiano L. P., Lea, SM, Andersen, GR, Oliveira, CL, Gregers R Andersen, Cristiano L P Oliveira, Sottrup-Jensen, L, Discipio, Richard, Roversi, Pietro, Roversi, P   +34 more
core   +1 more source