Results 81 to 90 of about 1,060,485 (284)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Efficacy and safety of the investigational complement C5 inhibitor zilucoplan in patients hospitalized with Covid-19: an open-label randomized controlled trial [PDF]

Respir Res, 2022
De Leeuw E, Damme KFV, Declercq J, Bosteels C, Maes B, Tavernier SJ, Detalle L, Smart T, Glatt S, Debeuf N, Deckers J, Lameire S, Vandecasteele SJ, De Neve N, Demedts IK, Govaerts E, Knoop C, Vanhove K, Moutschen M, Terryn W, Depuydt P, Braeckel EV, Haerynck F, Hendrickx TC, Parrein V, Lalla M, Brittain C, Lambrecht BN.   +27 more
europepmc   +2 more sources

Inhibition of complement pathway activation with Pozelimab, a fully human antibody to complement component C5.

, 2020
Complement is a key component of the innate immune system. Inappropriate complement activation underlies the pathophysiology of a variety of diseases. Complement component 5 (C5) is a validated therapeutic target for complement-mediated diseases, but the
Marc W Retter, Nina Liu, Carmelo Romano, Michael P Rosconi, William C Olson, Randi Foster, George Ehrlich, William Poueymirou, Henry Chen, Gang Chen, Qian Zhang, Robert Babb, Hui Xiao, Brian Zambrowicz, Tammy Huang, Pamela Krueger, Olav Olsen, Ying Hu, Adrianna Latuszek, Yashu Liu, Marc Cao, Irena Lovric, Ashique Rafique, Carola Springer, Lori Morton, Ming Yuan, Jingtai Cao, Vishal Kamat   +27 more
core   +1 more source

A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo [PDF]

, 2000
The strongest susceptibility genes for the development of systemic lupus erythematosus (SLE) in humans are null mutants of classical pathway complement proteins. There is a hierarchy of disease susceptibility and severity according to the position of the
H. Terence Cook, Savill, John, Henson, Peter M, Cook, HT, Valerie A. Fadok, Taylor, P.R, Henson, PM, Mark J. Walport, Savill, JS, Walport, MJ, Philip R. Taylor, John S. Savill, Michael C. Carroll, Botto, M, Andrews, Mark, Taylor, PR, Fadok, Valerie A, Anna Carugati, Carroll, Michael C, Walport, Mark J, Carroll, MC, Marina Botto, Carugati, A, Peter M. Henson, Andrews, M, Mark Andrews, Botto, Marina, Fadok, VA, Carugati, Anna, Cook, H. Terence   +29 more
core   +1 more source

TED1 Promotes the Assembly of SCFD3‐D14‐D53 to Reinforce Strigolactone Signaling in Rice

Advanced Science, EarlyView.
This study identifies TED1 as a positive regulator of strigolactones (SL) signaling in rice. The ted1 mutants display dwarfism and increased tillering with significantly reduced SLs sensitivity. Through its longer C‐terminal region, TED1 interacts with D53 and D14 to promote the assembly of SCFD3‐D14‐D53, thereby facilitating the efficient ...
Sheng Luo, Chuanyin Wu, Miao Feng, Wenfan Luo, Rong Miao, Jinsheng Qian, Fan Wang, Chunlei Zhou, Bojuan Liu, Jiale Shao, Ziqi Xun, Yehui Xiong, Zhichao Zhao, Cailin Lei, Shanshan Zhu, Yulong Ren, Xin Wang, Xiuping Guo, Haiyang Wang, Zichao Li, Zhijun Cheng, Qibing Lin, Jianmin Wan   +22 more
wiley   +1 more source

Intermolecular Carbon–Carbon Naphthalene Coupling Involves a Radical Mechanism Driven by Cytochrome P450 in Alternaria alternata

Angewandte Chemie, EarlyView.
1,8‐DHN is an important intermediate to form complex aromatic ring systems. Phenol‐coupling reactions are important for the dimerization of two molecules. Here, we show that a fungal cytochrome P450 enzyme catalyzes specific C─C bonds. ABSTRACT Dihydroxynaphthalene (DHN) derivatives are precursors of biologically important molecules, including melanin ...
Jia Gao, Leyao Chen, Karin Steffen, Henrik Schweder, Birgit Schreckenberger, Shu‐Ming Li, Ben Auxier, Antonis Rokas, Reinhard Fischer   +8 more
wiley   +2 more sources

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Current status of stem cell transplantation in paroxysmal nocturnal hemoglobinuria

Journal of Applied Hematology, 2020
Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal, acquired hematopoietic stem cell disorder, which is caused by activation of the complement system leading to life-threatening manifestations such as hemolysis, thrombosis, and marrow failure ...
Akanksha Garg, Sandip Shah, Kamlesh Shah, Kinnari Patel   +3 more
doaj   +1 more source

Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement [PDF]

, 2007
The pathogenic spirochete Leptospira interrogans disseminates throughout its hosts via the bloodstream, then invades and colonizes a variety of host tissues.
Matthew L Rotondi, Trevor P Creamer, Henry A. Choy, Brissette Catherine A., Kraiczy Peter, DeMoll, Edward, Edward Demoll, Peter Kraiczy, Stevenson, Brian, Suchard, Marc A, Creamer, Trevor P., Cooley Anne E., Matthew L. Rotondi, Kraiczy, Peter, Suchard, Marc A., Marc A. Suchard, Haake David A., Marija Pinne, Brissette, Catherine A, Catherine A. Brissette, Cooley, Anne E., Marc A Suchard, DeMoll Edward, Creamer, Trevor P, Pinne Marija, Verma, Ashutosh, Miller M. Clarke, Choy Henry A., Miller, M. Clarke, M Clarke Miller, Choy, Henry A, Pinne, Marija, Catherine A Brissette, Trevor P. Creamer, Verma Ashutosh, Haake, David A, Anne E. Cooley, Brissette, Catherine A., Rotondi, Matthew L., Suchard Marc A., Stevenson Brian, Creamer Trevor P., Brian Stevenson, Ashutosh Verma, M. Clarke Miller, Miller, M Clarke, Rotondi, Matthew L, Haake, David A., Rotondi Matthew L., Henry A Choy, David A Haake, Cooley, Anne E, Choy, Henry A., Anne E Cooley, David A. Haake   +54 more
core   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source