Results 71 to 80 of about 19,166 (184)

A conformational change of complement C5 is required for thrombin-mediated cleavage, revealed by a novel ex vivo human whole blood model preserving full thrombin activity

, 2021
Thrombin activation of C5 connects thrombosis to inflammation. Complement research in whole blood ex vivo necessitates anticoagulation, which potentially interferes with the inflammatory modulation by thrombin. We challenged the concept of thrombin as an
Bergseth, Grethe,, Johnson, Christina, Mollnes, Tom Eirik,, Brekke, Ole Lars, Fure, Hilde,, Macpherson, Alex, Nilsson, Per, Johnson, Christina,, Pischke, Soeren E., Brekke, Ole-Lars, Schjalm, Camilla, Nilsson, Per H.,, Bergseth, Grethe, Haugaard-Kedstrom, Linda M.,, Landsem, Anne, Durrant, Oliver,, Quach, Quang Huy,, Schjalm, Camilla,, Brekke, Ole-Lars,, Durrant, Oliver, Haugaard-Kedström, Linda M., Pischke, Soeren E.,, Quach, Huy Quang, Quach, Quang Huy, Pischke, Soeren, Fure, Hilde, Nilsson, Per H., Mollnes, Tom Eirik, Bergseth, Grete, Macpherson, Alex,, van den Elsen, Jean, van den Elsen, Jean,, Huber-Lang, Markus, Landsem, Anne,, Huber-Lang, Markus,   +34 more
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Complement C5 activation during influenza A infection in mice contributes to neutrophil recruitment and lung injury [PDF]

, 2013
Influenza virus A (IAV) causes annual epidemics and intermittent pandemics that affect millions of people worldwide. Potent inflammatory responses are commonly associated with severe cases of IAV infection.
Mauro M Teixeira, Milene A Rachid, Garcia, Cristiana C., Remo C Russo, Teixeira Mauro M., Alves-Filho, Jose C., Alves Filho, Jose C., Miles A Nunn, Russo, Remo de Castro, Machado Alexandre V., Russo, Remo C., Rachid Milene A., Mauro M. Teixeira, Ryffel Bernhard, Alexandre V. Machado, Tavares, Luciana P., Luciana P Tavares, Bernhard Ryffel, Nunn, Miles A., Nunn Miles A., Machado, Alexandre V., Milene A. Rachid, Miles A. Nunn, Ryffel, Bernhard, Weston-Davies, Wynne, Machado, Alexandre de Magalhães Vieira, Garcia Cristiana C., José C Alves-Filho, Wynne Weston-Davies, Cristiana C. Garcia, Cristiana C Garcia, José C. Alves-Filho, Alves-Filho José C., Remo C. Russo, Rachid, Milene A., Alexandre V Machado, Weston-Davies Wynne, Luciana P. Tavares, Tavares Luciana P., Teixeira, Mauro M., Russo Remo C., Teixeira, Mauro Martins   +41 more
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Advancing therapeutic complement inhibition in hematologic diseases: PNH and beyond

, 2022
: Complement is an elaborate system of innate immunity. Genetic variants and autoantibodies leading to excessive complement activation are implicated in a variety of human diseases. Among them, the hematologic disease paroxysmal nocturnal hemoglobinuria (
Gavriilaki, Eleni, de Latour, Régis Peffault, Risitano, Antonio Maria   +2 more
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Tissue-Type Plasminogen Activator and Tenecteplase-Mediated Increase in Blood Brain Barrier Permeability Involves Cell Intrinsic Complement

Frontiers in Neurology, 2020
Background: Tissue-type plasminogen activator (t-PA) has been the mainstay of therapeutic thrombolysis for patients with acute ischaemic stroke (AIS). However, t-PA can cause devastating intracerebral hemorrhage.
Charithani B. Keragala, Trent M. Woodruff, Zikou Liu, Be'eri Niego, Heidi Ho, Zoe McQuilten, Robert L. Medcalf   +6 more
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Case report: persistent anemia after eculizumab in paroxysmal nocturnal hemoglobinuria: non-dominantly active intravascular hemolysis

Hematology
Objectives Paroxysmal nocturnal hemoglobinuria (PNH) is a rare condition characterized by intravascular hemolysis (IVH), thrombosis, and organ damage.
Baozhi Fang, Xiao Yu, Yifei Zhou, Qiudan Shen, Muzhi Yuan, Peng Wang, Mingen Lü, Guangsheng He   +7 more
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Effects of freezer storage time on levels of complement biomarkers

BMC Research Notes, 2017
Background There is uncertainty regarding how stable complement analytes are during long-term storage at – 80 °C. As part of our work program we have measured 17 complement biomarkers (C1q, C1 inhibitor, C3, C3a, iC3b, C4, C5, C9, FB, FD, FH, FI, TCC, Bb,
Angharad R. Morgan, Caroline O’Hagan, Samuel Touchard, Simon Lovestone, B. Paul Morgan   +4 more
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Triple-fusion protein (TriFu) : a potent, targeted, enzyme-like inhibitor of all three complement activation pathways [PDF]

The introduction of a therapeutic anti-C5 antibody into clinical practice in 2007 inspired a surge into the development of complement-targeted therapies. This has led to the recent approval of a C3 inhibitory peptide, an antibody directed against C1s and
Sonnentag, Sophia J., Dopler, Arthur, Kleiner, Katharina, Späth, Nadja, Boyanapalli, Ruby, Akilah, Amira, Anliker, Markus, Schmidt, Christoph Q., Garg, Brijesh K., Schrezenmeier, Hubert, Höchsmann, Britta Elisabeth Hedwig, Huber-Lang, Markus, Mannes, Marco   +12 more
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Correlation between a 2-week change in platelet count and clinical outcomes after the initiation of ravulizumab treatment in adult patients with atypical hemolytic uremic syndrome: post-hoc analysis of the phase III trial

Thrombosis Journal
Background Atypical hemolytic uremic syndrome (aHUS) is a rare disease with poor outcomes when untreated, in which ravulizumab or eculizumab are the standard of care where available.
Masanori Matsumoto, Akihiko Shimono, Jun Yokosawa, Keiichiro Hirose, Edward Wang, Shoichi Maruyama   +5 more
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Conserved Surface-Exposed K/R-X-K/R Motifs and Net Positive Charge on Poxvirus Complement Control Proteins Serve as Putative Heparin Binding Sites and Contribute to Inhibition of Molecular Interactions with Human Endothelial Cells: a Novel Mechanism for Evasion of Host Defense

, 2000
Vaccinia virus complement control protein (VCP) has been shown to possess the ability to inhibit both classical and alternative complement pathway activation.
Shchelkunov, SN, Reynolds, DN, Kotwal, GJ, Justus, DE, Srisatjaluk, R, Loparev, VN, Totmenin, AV, Keeling, KL, Smith, SA, Parkinson, J, Barlow, PN, Mullin, NP   +11 more
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Design and Biological Evaluation of the Long-Acting C5-Inhibited Ornithodoros moubata Complement Inhibitor (OmCI) Modified with Fatty Acid

Disorder of complement response is a significant pathogenic factor causing some autoimmune and inflammation diseases. The Ornithodoros moubata Complement Inhibitor (OmCI), a small 17 kDa natural protein, was initially extracted from soft tick salivary ...
Xiaowan Li (3336774), Yandan Wang (741329), Yuanzhen Dong (11284302), Jun Feng (116162), Zongqing Huang (18333860), Wenwen Shangguan (10223915), Meiqing Feng (447657)   +6 more
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