Results 51 to 60 of about 19,166 (184)

Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis [PDF]

, 2017
Bacterial sepsis triggers robust activation of the complement system with subsequent generation of anaphylatoxins (C3a, C5a) and the terminal complement complex (TCC) that together contribute to organ failure and death.
Popescu, Narcis Ioan, Cristina Lupu, Tom Eirik Mollnes, DeMarco, Steven J., Florea Lupu, Chaaban, Hala, Lupu, Cristina, Patel, Maulin Mukeshchandra, Hala Chaaban, Coggeshall, K. Mark, Robert Silasi, Silasi, Robert, Mollnes, Tom Eirik, Keshari, Ravi Shankar, Lupu, Florea, Ravi Shankar Keshari, Maulin Mukeshchandra Patel, K. Mark Coggeshall, Narcis Ioan Popescu, Steven J. DeMarco   +19 more
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Structural basis for therapeutic inhibition of complement C5.

, 2016
Activation of complement C5 generates the potent anaphylatoxin C5a and leads to pathogen lysis, inflammation and cell damage. The therapeutic potential of C5 inhibition has been demonstrated by eculizumab, one of the world's most expensive drugs. However,
Elmlund, H, Yang I Li, Johnson, S, Nunn, MA, Johnson, Steven, Jore, Matthijs M., Li, Yang I., Susan M Lea, Lea, SM, Natalie M Barber, Devon Sheppard, Lea, Susan M., Li, YI, Sheppard, Devon, Barber, Natalie M., Steven Johnson, Miles A Nunn, Matthijs M Jore, Barber, NM, Elmlund, Hans, Jore, MM, Nunn, Miles A., Sheppard, D, Hans Elmlund   +23 more
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Targeted management of coexistent severe thrombophilias—A case report of a successful pregnancy despite paroxysmal nocturnal hemoglobinuria and hereditary protein C deficiency

eJHaem
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by the absence of complement regulatory proteins on the surface of erythrocytes, leading to intravascular hemolysis and thrombosis.
Julien Dereme, Matthew Goodyer, David Baud, Lorenzo Alberio, Francesco Grandoni, Mathilde Gavillet   +5 more
doaj   +1 more source

Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodies

Blood Advances, 2018
: The complement and coagulation cascades interact at multiple levels in thrombosis and inflammatory diseases. In venous thrombosis, complement factor 3 (C3) is crucial for platelet and tissue factor (TF) procoagulant activation dependent on protein ...
Nadine Müller-Calleja, Svenja Ritter, Anne Hollerbach, Tanja Falter, Karl J. Lackner, Wolfram Ruf   +5 more
doaj   +1 more source

Clinical Utility and Potential Cost Savings of Pharmacologic Monitoring of Eculizumab for Complement-Mediated Thrombotic Microangiopathy

Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 2022
One of the treatment options for complement-mediated thrombotic microangiopathy (CM-TMA), also known as atypical hemolytic uremic syndrome, is the administration of the C5 complement inhibitor eculizumab.
Meera Sridharan, MD, PhD, Ronald S. Go, MD, Maria A.V. Willrich, PhD   +2 more
doaj   +1 more source

Incomplete inhibition by eculizumab: mechanistic evidence for residual C5 activity during strong complement activation

, 2017
Eculizumab inhibits the terminal, lytic pathway of complement by blocking the activation of the complement protein C5 and shows remarkable clinical benefits in certain complement-mediated diseases.
Christoph Q. Schmidt, Lambris, John D., Inge von Zabern, Höchsmann, Britta, Nadine Kuhn, Christof Weinstock, Weinstock, Christof, Markus J. Harder, Skerra, Arne, Arne Skerra, John D. Lambris, Thomas Simmet, Anliker, Markus, Daniel Ricklin, Schmidt, Christoph Q., Schrezenmeier, Hubert, Hubert Schrezenmeier, Markus Anliker, Simmet, Thomas, Ricklin, Daniel, Britta Höchsmann, Harder, Markus J., Kuhn, Nadine, von Zabern, Inge   +23 more
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Investigational drugs inhibiting complement for the treatment of geographic atrophy.

, 2023
INTRODUCTION Geographic atrophy (GA) is a progressive form of age-related macular degeneration (AMD) that leads to severe visual impairment and central vision loss.
Ferro Desideri, Lorenzo, Artemiev, Dmitri, Paschon, Karin, Zandi, Souska, Bernardi, Enrico, Zinkernagel, Martin, Anguita, Rodrigo   +6 more
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Zilucoplan, a macrocyclic peptide inhibitor of human complement component 5, uses a dual mode of action to prevent terminal complement pathway activation

Frontiers in Immunology, 2023
IntroductionThe complement system is a key component of the innate immune system, and its aberrant activation underlies the pathophysiology of various diseases.
Guo-Qing Tang, Yalan Tang, Ketki Dhamnaskar, Michelle D. Hoarty, Rohit Vyasamneni, Douangsone D. Vadysirisack, Zhong Ma, Nanqun Zhu, Jian-Guo Wang, Charlie Bu, Bestine Cong, Elizabeth Palmer, Petra W. Duda, Camil Sayegh, Alonso Ricardo   +14 more
doaj   +1 more source

Structure and influence of tick complement inhibitor on human complement component 5

, 2008
To provide insight into the structural and functional properties of human complement component 5 (C5), we determined its crystal structure at a resolution of 3.1 Å.
Pietro Roversi, Lars Sottrup-Jensen, Nunn, MA, Folmer Fredslund, Laursen, Nick S., Pedersen, Jan S., Susan M Lea, Andersen, Gregers R., Jenner, Lasse, Lea, Susan M., Laursen, NS, Lasse Jenner, Jan S Pedersen, Miles A Nunn, Jenner, L, Sottrup-Jensen, Lars, Lea, Susan, Richard Discipio, Oliveira, CLP, Nunn, Miles A., Fredslund, F, Pedersen, JS, Discipio, R, Nick S Laursen, Fredslund, Folmer, Oliveira, Cristiano L. P., Lea, SM, Andersen, GR, Oliveira, CL, Gregers R Andersen, Cristiano L P Oliveira, Sottrup-Jensen, L, Discipio, Richard, Roversi, Pietro, Roversi, P   +34 more
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Simultaneous C5 and CD14 inhibition limits inflammation and organ dysfunction in pig polytrauma

Frontiers in Immunology, 2022
Dysfunctional complement activation and Toll-like receptor signaling immediately after trauma are associated with development of trauma-induced coagulopathy and multiple organ dysfunction syndrome.
Ludmila Lupu, Klemens Horst, Johannes Greven, Ümit Mert, Judith A.K. Ludviksen, Kristin Pettersen, Corinna Lau, Yang Li, Annette Palmer, Kang Qin, Xing Zhang, Benjamin Mayer, Martijn van Griensven, Markus Huber-Lang, Frank Hildebrand, Tom Eirik Mollnes, Tom Eirik Mollnes, Tom Eirik Mollnes   +17 more
doaj   +1 more source