Results 61 to 70 of about 19,166 (184)
Complement component C5 and TLR molecule CD14 mediate heme-induced thromboinflammation in human blood [PDF]
, 2019 Heme is a critical danger molecule liberated from hemeproteins in various conditions, including from hemoglobin in hemolytic diseases. Heme may cause thromboinflammatory damage by activating inflammatory and hemostatic pathways, such as complement, the ...Fløisand, Yngvar, Gerogianni, Alexandra, Gerogianni, Alexandra,, Mollnes, Tom Eirik,, Thomas, Anub Mathew, Nilsson, Per, Barratt-Due, Andreas, Lau, Corinna, Lau, Corinna,, McAdam, Martin Berner, Espevik, Terje, Espevik, Terje,, Nilsson, Per H.,, Mollnes, Tom Eirik, Floisand, Yngvar,, Barratt-Due, Andreas,, Thomas, Anub M.,, McAdam, Martin B., +17 morecore +1 more sourceReal-world use of complement inhibitors for haemolytic uraemic syndrome: an analysis of the European Rare Kidney Disease Registry cohortResearch in context
EClinicalMedicineSummary: Background: Although terminal complement inhibitors transformed the prognosis of atypical haemolytic uraemic syndrome (aHUS) from dismal to favourable, treatment approaches vary due to the intermittent disease nature and high costs ...Aleksandra Vujović, Anne-Laure Sellier-Leclerc, Maria Cristina Mancuso, Olivia Boyer, Atif Awan, Antonio Gargiulo, Sebastian Loos, Marc Fila, Augustina Jankauskiene, Gema Ariceta, Nele Kanzelmeyer, Enrico Vidal, Maria Van Dyck, Tanja Kersnik Levart, Naděžda Šimánková, Stephane Decramer, Jonas Hofstetter, Marina Vivarelli, Savino Sciascia, Nicole C.A.J. van de Kar, Franz Schaefer, Nicole C.A.J. van de Kar, Marina Vivarelli, Savino Sciascia, David Kavanagh, René Andersen, Mia Faerch, Soren Rittig, Miquel Blasco, Pedro Arango Sancho, Alvaro Madrid, Gema Ariceta, Loreto Gesualdo, Camillo Carrara, Piero Ruggenenti, Kai-Uwe Eckardt, Jan Halbritter, Dominik Müller, Adrian Schreiber, Evelyn Seelow, Yahsou Delmas, Jerome Harambat, Brigitte Llanas, Nathalie Godefroid, Eric Goffin, Johann Morelle, Adrian Catalin Lungu, George Reusz, Péter Sallay, Attila Szabo, Kalman Tory, Jan Ulrich Becker, Kathrin Burgmaier, Volker Burst, Sandra Habbig, Max Liebau, Roman-Ulrich Mueller, Lutz Weber, Mette Damholt, Anne-Lise Kamper, Karl Emil Nelveg-Kristensen, Hanne Nørgaard, Ida Maria Schmidt, Soeren Soerensen, Wladimir Szpirt, Agnieszka Jaskólska, Monika Miklaszewska, Anna Moczulska, Elżbieta Szczęsny-Choruz, Katarzyna Zachwieja, Peter Conlon, Atif Awan, Michael Wiesener, Anja Büscher, Rainer Büscher, Lars Pape, Francesca Becherucci, Paola Romagnani, Ann Raes, Thomas Renson, Evelien Snauwaert, Johan Vande Walle, Jill Vanmassenhove, Mark Eijgelsheim, Casper Franssen, Coen Stegeman, Florian Grahammer, Thomas Henne, Tobias Huber, Christian Krebs, Sebastian Loos, Anne Mühlig, Jun Oh, Ulf Panzer, Raphael Schild, Jessica Kaufeld, Stefanie Haeberle, Franz Schaefer, Tanja Wlodkowski, Juuso Tainio, Elisa Ylinen, Obbo Bredewold, Wieneke Michels, Dorien Peters, Antonius Rabelink, Arghya Ray, Joris Rotmans, Siebe Spijker, Y.K. Onno Teng, Kathleen Claes, Noel Knops, Tanja Kersnik Levart, Anamarija Meglič, Gregor Novljan, Agnieszka Gach, Monika Pawlak-Bratkowska, Małgorzata Stańczyk, Marcin Tkaczyk, Pierre Cochat, Anne-Laure Sellier-Leclerc, Teresa Cavero, Eduardo Guiterrez, Joaquin Martinez, Enrique Morales, Hernando Trujillo, Gianluigi Ardissino, Valentina Capone, Sara Testa, Denis Morin, Martin Konrad, Ilaria Luongo, Gabriele Malgieri, Luigi Annicchiarico Petruzzelli, Wilbert van der Meijden, Jack Wetzels, Mattia Parolin, Enrico Vidal, Thérésa Kwon, Olivia Boyer, Aude Servais, Laurent Mesnard, Alena Parikova, Silvie Rajnochova-Bloudickova, Janka Slatinska, Ondrej Viklicky, Martin Bezdicka, Nadezda Simankova, Dana Thomasova, Jakub Zieg, Francesco Emma, Rocco Baccaro, Giuseppe Grandaliano, Alessandro Naticchia, Francesco Pesce, Margherita Baldassarri, Andrea Guarnieri, Anna Maria Pinto, Alessandra Renieri, Stephane Decramer, Stanislas Faguer, David Ribes, Thomas Simon, Stephanie Tellier, Daniel Gale, Christoph Licht, Michal Malina, Candice Roufosse, Neil Sheerin, Susana Carvajal Arjona, Renée de Wildt, Uwe Korst, Christiane Mockenhaupt, Francisco Monfort, Mireya Vicenta Rios Carratala +173 moredoaj +1 more sourceCombined inhibition of complement (C5) and CD14 markedly attenuates inflammation, thrombogenicity, and hemodynamic changes in porcine sepsis
, 2013 Complement and the TLR family constitute two important branches of innate immunity. We previously showed attenuating effects on inflammation and thromogenicity by inhibiting the TLR coreceptor CD14 in porcine sepsis. In the present study, we explored the Nunn, Miles, Hellerud, Bernt C., Bongoni, Anjan K., Scott, Helge, Egge, Kjetil, Barratt-Due, Andreas, Pischke, Søren, Sokolov, Andrey, Rieben, Robert, Pharo, Anne, Lindstad, Julie K., Pischke, Soren, Mollnes, Tom E., Thorgersen, Ebbe B. +13 morecore +1 more sourceSwitching to subcutaneous zilucoplan from intravenous complement component 5 inhibitors in generalised myasthenia gravis: a phase IIIb, open-label study
Therapeutic Advances in Neurological DisordersBackground: Zilucoplan, a peptide complement component 5 (C5) inhibitor, is self-administered as a subcutaneous (SC) injection, which offers an alternative to intravenous infusion of antibody-based complement C5 inhibitors.Miriam Freimer, Urvi Desai, Raghav Govindarajan, Min K. Kang, Shaida Khan, Bhupendra Khatri, Todd Levine, Samir Macwan, Perry B. Shieh, Michael D. Weiss, Jos Bloemers, Babak Boroojerdi, Eumorphia Maria Delicha, Andreea Lavrov, Puneet Singh, James F. Howard +15 moredoaj +1 more sourceDevelopment of RA101348, a Potent Cyclic Peptide Inhibitor of C5 for Complement-Mediated Diseases
Blood, 2014 Abstract The involvement of complement in the pathogenesis of serious, life-threatening diseases underscores the importance in developing therapeutics to intervene in this cascade. Specifically, dysregulation of the complement system is central in multiple hematologic conditions.Alonso Ricardo, Michelle Arata, Steven J DeMarco, Ketki Dhamnaskar, Robert Hammer, Kristopher Josephson, Kathleen Seyb, Sylvia Tobe, Zhaolin Wang, Hong Zheng, Douglas Treco +10 moreopenaire +1 more sourceCell viability of microglial cells after 48 hour incubation with human complement components (C1q, C1 inhibitor, C4, C5 and C9), both individually and in combination with each other; and a human complement standard containing complement components C1q, C2, C3, C4, C5, C6, C7, C8, C9 and factor B.
, 2015 Cell viability was determined by MTT assay of cell proliferation and intracellular NAD levels (for complement standard samples). Replicates included n = 6 for cell proliferation measurements and, n = 3 for NAD concentrations.* p ≤ 0.05 vs Control,** p ...Nicole Kochan (704514), Tharusha Jayasena (704509), Mark Raftery (704511), Mark Hill (704512), George Smythe (704510), Julian Trollor (704513), Nady Braidy (261733), Henry Brodaty (158887), Anne Poljak (158842), Perminder Sachdev (377263) +9 morecore +1 more sourceStructural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
, 2009 Staphylococcus aureus secretes the SSL7 protein as part of its immune evasion strategy. The protein binds both complement C5 and IgA, yet it is unclear whether SSL7 cross-links these two proteins and, if so, what purpose this serves the pathogen. We have Fredslund, F, Bjerre, M, Gordon, NL, Hermans, Stefan, Anderssen, G, Wines, B, Jackson, NJH, Christensen, JB, Laursen, NS, Spillner, E, Lorenz, Natalie, Sottrup-Jensen, L, Jensen, M, Fraser, John +13 morecore +1 more source
