Results 231 to 240 of about 68,603 (270)

Complement-Dependent Cytotoxicity Crossmatch

2013
The complement-dependent cytotoxic crossmatch is an informative test that detects alloantibodies in pre- and post-transplant patients, which may dictate clinical management of transplant patients. While challenging to perform, the cytotoxic crossmatch represents the only assay that provides direct evidence for the presence of potentially pathologic (i ...
Jeremy Ryan, Peña, Donna, Fitzpatrick, Susan L, Saidman   +2 more
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Complement enhances antiviral antibody-dependent cell cytotoxicity

Nature, 1977
ANTIBODY-DEPENDENT cell cytotoxicity (ADCC) is an in vitro phenomenon that can be demonstrated with a variety of target cell systems and can be mediated by several types of effector cells1–3. The effectors in ADCC must bear a surface receptor for Fc, and this receptor binds with antibody which is in turn bound to the target cell.
B T, Rouse, A S, Grewal, L A, Babiuk
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Monoclonal anticolon carcinoma antibodies in complement‐dependent cytotoxicity

International Journal of Cancer, 1981
AbstractHybridoma‐derived monoclonal anticolon carcinoma (ACC) antibodies mediated specific complement‐dependent cytotoxicity (CDC) against human colon carcinoma cells either grown in culture or obtained directly from patients. These ACC antibodies did not lyse normal colonic mucosa or other normal and malignant human cells.
D M, Herlyn, H, Koprowski
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Complement-Dependent Cytotoxicity for Negative Selection at the mRNA Level

Immunological Investigations, 1992
Complement-Dependent Cytotoxicity (CDC) is a common technique used for isolating and characterizing cell populations. However, the molecular events resulting from CDC-mediated cell injury remain obscure. In order to use CDC as a selection procedure for studies at the RNA level, we examined if CDC is associated with rapid degradation of RNAs from target
Gill, N. S., Madrenas, J., Halloran, P. F.   +2 more
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Separation of complement‐dependent and lymphocytedependent cytotoxic activity in human sera

European Journal of Immunology, 1975
AbstractTwo human sera having both complement‐dependent and lymphocyte‐dependent antibody activities (CDA, LDA) were applied to isoelectrofocusing columns. Maximum LDA activity for both sera was found focused at a higher pH than maximum CDA activity. The studies suggest that LDA molecules may exist without having complement‐dependent activity.
J L, Miller, D L, Mann, I, Yust
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Antibody-Dependent Lymphoid Cell-Mediated Cytotoxicity: Role of Complement

The Journal of Immunology, 1974
Abstract Unsensitized lymphoid cells have the capacity to destroy antibody-coated target cells in vitro. Definitive studies to rule out the participation of complement (C) components in this reaction require a system with a complete absence of C components and with no possibility of endogenous synthesis of C by cells in culture.
J A, Van Boxel, W E, Paul, I, Green, M M, Frank   +3 more
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Enhanced cytotoxicity of amyloid β-peptide by a complement dependent mechanism

Neuroscience Letters, 1994
Amyloid beta-peptide (A beta) has been shown to activate the classical complement pathway in vitro. Here, we demonstrate that this interaction is fully capable of killing cells and damaging cellular processes in mixed hippocampal cultures from embryonic day 18 rat fetuses.
J, Schultz, J, Schaller, M, McKinley, B, Bradt, N, Cooper, P, May, J, Rogers   +6 more
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Anti-αGal-dependent complement-mediated cytotoxicity in metastatic melanoma

Melanoma Research, 2006
Antibodies to the cell surface disaccharide galactose(alpha1,3)galactose (alphaGal) are the most prevalent natural antibodies in human serum. The anti-alphaGal immunoglobulin M-dependent activation of complement causes hyperacute rejection of organ transplants from discordant species by human recipients.
James M G, Larkin, Peter J, Norsworthy, Roger P, A'Hern, Tim G, Eisen, Martin E, Gore, Colin D, Porter   +5 more
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Complement‐dependent cytotoxic antibodies in the course of cervical carcinoma

International Journal of Cancer, 1977
AbstractComplement‐dependent cytotoxic antibodies to three cervical carcinoma cell lines (Me‐180, SW‐732 and HeLa) and to Herpes simplex virus type 2 (HSV‐2)‐infected cells were determined in a long‐term study of women with cervical carcinoma. Cytolysis of surface antigens differed significantly between the cervical carcinoma cell lines and HSV‐2 ...
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Complement-dependent and complement-independent cytotoxicity of polyclonal antithymocyte globulins in chronic lymphocytic leukemia

Leukemia Research, 2008
Despite important progress in its management, chronic lymphocytic leukemia (CLL) remains incurable with standard therapies. Allogeneic stem cell transplantation (SCT) is a potentially curative therapy for patients with CLL. Polyclonal antithymocyte (or anti-T-cell) globulins (ATGs) are used for conditioning in allogeneic SCT mainly due to their anti-T ...
Francis A, Ayuk, Nabil, Atassi, Gunther, Schuch, Sormeh, Mina, Lubin, Fang, Carsten, Bokemeyer, Boris, Fehse, Axel R, Zander, Nicolaus, Kröger   +8 more
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