, 2002 Several γ-herpesviruses encode homologs of host regulators of complement activation (RCA) proteins, suggesting that they have evolved immune evasion strategies targeting complement.
Kapadia, Sharookh B. +3 more
core +1 more source
Novel mechanisms of immune evasion by Schistosoma mansoni
Memorias do Instituto Oswaldo Cruz, 1995 The interaction of Schistosoma mansoni with its host's immune system is largely affected by multiple specific and non-specific evasion mechanisms employed by the parasite to reduce the host's immune reactivity. Only little is known about these mechanisms
Zvi Fishelson
doaj +1 more source
Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation
Advanced Science, EarlyView.VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang +15 more
wiley +1 more source
Allosteric inhibition of complement function by a staphylococcal immune evasion protein
, 2010 The complement system is a major target of immune evasion by Staphylococcus aureus . Although many evasion proteins have been described, little is known about their molecular mechanisms of action.
Georgia Sfyroera +11 more
core +1 more source
Advanced Science, EarlyView.Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye +9 more
wiley +1 more source
Human complement control and complement evasion by pathogenic microbes - Tipping the balance [PDF]
, 2013 Complement is a central homeotic system of mammals and represents the first defense line of innate immunity. The human complement system is aimed to maintain homeostasis by recognizing and removing damaged or modified self material, as well as infectious
Peter F. Zipfel +5 more
core +1 more source
Genome-wide screen in human plasma identifies multifaceted complement evasion of Pseudomonas aeruginosa. [PDF]
PLoS Pathog, 2023 Janet-Maitre M +13 more
europepmc +1 more source
Enzymatic DNA Reaction Networks for Orchestrating Stimuli‐Dependent Temporal Molecular Pulse
Advanced Science, EarlyView.We present an enzymatic DNA reaction network (EDRN) that encodes nucleic‐acid targets in time, converting inputs into a universal strand and then into programmable transient fluorescence pulses. With time‐color multiplexing, EDRN enables single‐tube high‐plex nucleic acid detection and shows strong agreement with clinical sequencing across 32 specimens.
Jiayu Yang +7 more
wiley +1 more source
The role of the Streptococcus pneumoniae capsule in interactions with complement and phagocytes
, 2010 The Streptococcus pneumoniae capsule is an essential virulence factor and it is ideally situated to modulate interactions between the bacteria and host immune cells.
Hyams, C.J.
core
Recruitment of factor H as a novel complement evasion strategy for blood-stage plasmodium falciparum infection [PDF]
, 2016 The human complement system is the frontline defense mechanism against invading pathogens. The coexistence of humans and microbes throughout evolution has produced ingenious molecular mechanisms by which microorganisms escape complement attack.
Barlow, Paul Nigel +9 more
core +1 more source