Results 151 to 160 of about 392,488 (288)
The role of the Streptococcus pneumoniae capsule in interactions with complement and phagocytes [PDF]
, 2010 The Streptococcus pneumoniae capsule is an essential virulence factor and it is ideally situated to modulate interactions between the bacteria and host immune cells.
Hyams, C.J.
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Functional Identification of Complement Factor D and Analysis of Its Expression during GCRV Infection in Grass Carp (Ctenopharyngodon idella). [PDF]
Int J Mol Sci, 2021 Ding C +5 more
europepmc +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
ヒト乳腺上皮細胞による補体D因子産生(自然科学系) [PDF]
, 1999 Complement components were assayed in culture supernatants of normal human mammary epithelial cells (HMEC) and 3 kinds of mammary cancer-derived cell lines, MRK-nu-1, YMB-1 and YMB-1 E.
北村, 肇 +3 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
胃癌由来培養細胞による補体D因子産生(自然科学系) [PDF]
, 1997 Factor D, a serum protein of the alternative pathway of the complement system, was assayed by sandwich ELISA in culture supernatants of 4 kinds of gastric cancer-derived cell lines, MKN28, MKN74, MKN45 and KATO-III.
北村, 肇 +3 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Structure of an active N-terminal fragment of human complement factor H [PDF]
, 2008 Factor H (FH) is a key regulator of the complement system, the principal molecular component of innate immunity in humans. The tight regulation of the alternative pathway (AP) of complement by FH occurs on host cells as well as in fluid phase.
Hocking, Henry G.
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