Results 151 to 160 of about 1,227,803 (177)

PolySialic Acid Nanoparticles Actuate Complement-Factor-H-Mediated Inhibition of the Alternative Complement Pathway: A Safer Potential Therapy for Age-Related Macular Degeneration. [PDF]

Pharmaceuticals (Basel)
Peterson SL, Krishnan A, Patel D, Khanehzar A, Lad A, Shaughnessy J, Ram S, Callanan D, Kunimoto D, Genead MA, Tolentino MJ.   +10 more
europepmc   +1 more source

Levels of complement factor H-related 4 protein do not influence susceptibility to age-related macular degeneration or its course of progression. [PDF]

Nat Commun
Zouache MA, Richards BT, Pappas CM, Anstadt RA, Liu J, Corsetti T, Matthews S, Seager NA, Schmitz-Valckenberg S, Fleckenstein M, Hubbard WC, Thomas J, Hageman JL, Williams BL, Hageman GS.   +14 more
europepmc   +1 more source

[Complement factor H and macular degeneration].

Gaceta medica de Mexico, 2005
openaire   +1 more source

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Functional Anatomy of Complement Factor H

Biochemistry, 2013
Factor H (FH) is a soluble regulator of the proteolytic cascade at the core of the evolutionarily ancient vertebrate complement system. Although FH consists of a single chain of similar protein modules, it has a demanding job description. Its chief role is to prevent complement-mediated injury to healthy host cells and tissues. This entails recognition
Elisavet, Makou, Andrew P, Herbert, Paul N, Barlow   +2 more
openaire   +2 more sources

Anti-complement-factor H-associated glomerulopathies

Nature Reviews Nephrology, 2016
Atypical haemolytic uraemic syndrome (aHUS), an important cause of acute kidney injury, is characterized by dysregulation of the complement pathway, frequent need for dialysis, and progression to end-stage renal disease. Autoantibodies against complement factor H (FH), the main plasma regulatory protein of the alternative pathway of the complement ...
Marie-Agnes Dragon, Durey, Aditi, Sinha, Shambhuprasad Kotresh, Togarsimalemath, Arvind, Bagga   +3 more
openaire   +2 more sources

Complement factor H: a guardian within?

Kidney International, 2021
The glomerular endothelium produces the key complement regulator factor H (FH), but its role in the endothelial cells protection and functional integrity is unclear. In this edition of Kidney International, Mahajan et al. demonstrate that the endothelial-intrinsic FH is important for the cytoskeletal architecture, monolayer integrity, proliferation ...
Idris Boudhabhay, Lubka T. Roumenina
openaire   +2 more sources

Complement regulator factor H in multiple sclerosis

Journal of Cellular Biochemistry, 2011
A recent proteomic study published in this journal demonstrated lower cerebrospinal fluid (CSF) expression of factor H (fH), an important complement regulator, along with two other complement proteins, in active multiple sclerosis (MS) patients. We have previously demonstrated raised serum fH levels in MS and here, an extended analysis, quantifying fH ...
Gillian, Ingram, Svetlana, Hakobyan, Samantha, Loveless, Neil, Robertson, B Paul, Morgan   +4 more
openaire   +2 more sources

Ancient Origin of Human Complement Factor H

Journal of Molecular Evolution, 1998
We studied the evolutionary history of two homologous proteins of the human complement system, factor H (FH) and the alpha chain of the C4b binding protein (C4bpalpha), and included in this study the related proteins from the barred sand bass (P. nebulifer) and the nematode C. elegans. Phylogenetic trees inferred from individual short consensus repeats
J, Krushkal, C, Kemper, I, Gigli
openaire   +2 more sources

Sequence polymorphism of human complement factor H

Immunogenetics, 1988
Factor H is a major regulatory protein of the complement system. The complete cDNA coding sequence has been derived from overlapping clones, and a polymorphism at base 1277 has been characterized. In four clones there is a T at nucleotide 1277 and in two others there is a C.
Day, Anthony J., Willis, Antony C., Ripoche, Jean, Sim, Robert B.   +3 more
openaire   +2 more sources