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The lectin self of complement factor H

Current Opinion in Structural Biology, 2017
Complement, a part of the humoral innate immune system, is divided into three pathways. The classical and mannose-binding lectin pathways are triggered by specific recognition of foreign targets. Conversely, the alternative pathway (AP) is actively down-regulated on host tissue.
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Isolation of bovine complement factor H.

Veterinary Immunology and Immunopathology, 1987
A bovine serum protein, initially recognized by its inhibitory effect on the hemolytic activity of the bovine alternative pathway was isolated from fresh bovine serum by polyethylene glycol precipitation and chromatography on DEAE-Sephacel, CM-Sephadex A-50 and Sephadex G-200. The protein, a single chain polypeptide with an apparent molecular weight of
A, Mhatre, W P, Aston
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Genetic analysis of human complement factor H polymorphisms

ELECTROPHORESIS, 2007
AbstractHuman complement factor H (factor H) is polymorphic, with five previously reported FH alleles and three previously reported HF alleles (HF*A, HF*B, and HF*Q0). The relationship between the FH and HF alleles is not clear, and the genetic basis of factor H phenotypes has not yet been identified.
Rie, Susukida   +3 more
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The Pleiotropy of Complement Factor H

JAMA Ophthalmology, 2023
Elizabeth J, Rossin, Lucia, Sobrin
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Complement Factor H

Ophthalmology, 2007
M, de la Fuente   +8 more
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Complement Factor H (CFH)

2016
Eduardo Lamas-Basulto   +2 more
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Complement factor H: beyond aHUS

Nature Reviews Nephrology, 2017
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