Results 161 to 170 of about 2,740,548 (363)

Complement factor I and age-related macular degeneration.

Molecular vision, 2015
The complement system has been implicated in the pathogenesis of age-related macular degeneration (AMD). Complement factor I (CFI) is a serum protease that inhibits all complement pathways. A previous multicenter study identified a single missense CFI mutation (p.Gly119Arg) in 20/3,567 (0.56%) of AMD cases versus 1/3,937 (0.025%) of controls, thus ...
Alexander, Philip, Gibson, Jane, Cree, Angela J, Ennis, Sarah, Lotery, Andrew J   +4 more
openaire   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report. [PDF]

Neurol Neuroimmunol Neuroinflamm, 2023
Rolfes M, Harroud A, Zorn KC, Tubati A, Omura C, Kurtz K, Matloubian M, Berger A, Chiu CY, Wilson MR, Ramachandran PS.   +10 more
europepmc   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

The role of complement in Streptococcus pneumoniae-associated haemolytic uraemic syndrome [PDF]

, 2013
Background. Atypical forms of haemolytic uraemic syndrome (aHUS) include HUS caused by defects in the regulation of alternative complement pathway and HUS linked to neuraminidase- producing pathogens, such as Streptococcus pneumoniae. Increasing data
Szilágyi, Ágnes
core  

Intermediate Jacobians and Hodge Structures of Moduli Spaces [PDF]

Proc. Indian Acad. Sci. Math. Sci. 110 (2000), 1999
Let SU_X(n,L) be the moduli space of rank n semistable vector bundles with fixed determinant L on a smooth projective genus g>1 curve X. Let SU_X^s(n,L) denote the open subset parameterizing stable bundles. We show that for small i, the mixed Hodge structure on H^i(SU_X^s(n, L), Q) is independent of the degree of L, and hence pure of weight i. Moreover
arxiv  

Restriction of Measles Virus RNA Synthesis by a Mouse Host Cell Line: trans -Complementation by Polymerase Components or a Human Cellular Factor(s) [PDF]

, 2002
S. Vincent, Isabelle Tigaud, Henriette Schneider, Christian J. Buchholz, Yusuke Yanagi, Denis Gerlier   +5 more
openalex   +1 more source

Rapid genome sequencing identifies novel variants in complement factor I. [PDF]

Cold Spring Harb Mol Case Stud, 2022
Rodriguez KM, Vaught J, Dilley M, Ellsworth K, Heinen A, Abud EM, Zhang Y, Smith RJH, Sheets R, Geng B, Hoffman HM, Worthen HM, Dimmock D, Coufal NG.   +13 more
europepmc   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

The YeastCandida albicansBinds Complement Regulators Factor H and FHL-1 [PDF]

, 2002
Taru Meri, Andrea Hartmann, D. Lenk, Raimund Eck, Reinhard Würzner, Jens Hellwage, Seppo Meri, Peter F. Zipfel   +7 more
openalex   +1 more source