FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Post-Transplant Thrombotic Microangiopathy due to a Pathogenic Mutation in Complement Factor I in a Patient With Membranous Nephropathy: Case Report and Review of Literature. [PDF]
Front Immunol, 2022 Saleem M +4 more
europepmc +1 more source
Complete Reducibility in Good Characteristic
, 2016 Let $G$ be a simple algebraic group of exceptional type, over an algebraically closed field of characteristic $p \ge 0$. A closed subgroup $H$ of $G$ is called $G$-completely reducible ($G$-cr) if whenever $H$ is contained in a parabolic subgroup $P$ of $
Litterick, Alastair J., Thomas, Adam R.
core
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Functional Analysis of Variants in Complement Factor I Identified in Age-Related Macular Degeneration and Atypical Hemolytic Uremic Syndrome. [PDF]
Front Immunol, 2021 de Jong S +9 more
europepmc +1 more source
HylS’, a fragment of truncated hyaluronidase of Streptococcus suis , contributes to immune evasion by interaction with host complement factor C3b [PDF]
Jiajia Xu +10 more
openalex +1 more source
A soluble chimeric complement inhibitory protein that possesses both decay-accelerating and factor I cofactor activities. [PDF]
, 1997 Paul J. Higgins +5 more
openalex +1 more source