Results 181 to 190 of about 2,740,548 (363)

Complement C3 Is a Risk Factor for the Development of Diabetes [PDF]

, 2005
Gunnar Engström, Bo Hedblad, Karl‐Fredrik Eriksson, Lars Janzon, Folke Lindgärde   +4 more
openalex   +1 more source

Functional analysis of rare genetic variants in complement factor I in advanced age-related macular degeneration. [PDF]

Hum Mol Genet, 2022
Java A, Pozzi N, Schroeder MC, Hu Z, Huan T, Seddon JM, Atkinson J.   +6 more
europepmc   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

On additive complements in the complement of a set of natural numbers [PDF]

arXiv
Let $A$ be a set of natural numbers. A set $B$, a set of natural numbers, is an additive complement of the set $A$ if all sufficiently large natural numbers can be represented in the form $x+y$, where $x\in A$ and $y\in B$. Erd\H{o}s proposed a conjecture that every infinite set of natural numbers has a sparse additive complement, and in 1954, Lorentz ...
arxiv  

In Vivo Binding of Complement Regulator Factor H byStreptococcus pneumoniae [PDF]

, 2005
Lisa R. Quin, Stephanie Carmicle, Sandhya Dave, Michael K. Pangburn, Jason P. Evenhuis, Larry S. McDaniel   +5 more
openalex   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Proteomics and Microbiota Conjoint Analysis in the Nasal Mucus: Revelation of Differences in Immunological Function in Manis javanica and Manis pentadactyla

Animals
All eight pangolin species, especially captive Manis pentadactyla, are critically endangered and susceptible to various pathogenic microorganisms, causing mass mortality. They are involved in the complement system, iron transport system, and inflammatory
Qing Han, Yepin Yu, Hongbin Sun, Xiujuan Zhang, Ping Liu, Jianfeng Deng, Xinyuan Hu, Jinping Chen   +7 more
doaj   +1 more source

Rare complement factor I variants associated with reduced macular thickness and age-related macular degeneration in the UK Biobank. [PDF]

Hum Mol Genet, 2022
Tzoumas N, Kavanagh D, Cordell HJ, Lotery AJ, Patel PJ, Steel DH.   +5 more
europepmc   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

A Variational Beam Model for Failure of Cellular and Truss‐Based Architected Materials

Advanced Engineering Materials, EarlyView., 2023
Herein, a versatile and efficient beam modeling framework is developed to predict the nonlinear response and failure of cellular, truss‐based, and woven architected materials. It enables the exploration of their design space and the optimization of their mechanical behavior in the nonlinear regime. A variational formulation of a beam model is presented
Konstantinos Karapiperis, Kaoutar Radi, Zifan Wang, Dennis M. Kochmann   +3 more
wiley   +1 more source