The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications. [PDF]
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Pan-cancer analysis of Sushi domain-containing protein 4 (SUSD4) and validated in colorectal cancer. [PDF]
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Unraveling the Role of the Multifunctional Groups in the Adsorption of l-Cysteine on Rutile TiO<sub>2</sub>(110). [PDF]
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Rare predicted loss-of-function and damaging missense variants in CFHR5 associate with protection from age-related macular degeneration. [PDF]
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Identification and validation of a tear fluid-derived protein biomarker signature in patients with amyotrophic lateral sclerosis. [PDF]
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Cyanate as an Inactivator of Complement Proteins
The Journal of Immunology, 1975Abstract Sodium cyanate added to normal human serum or serum from patients with sickle-cell disease resulted in the functional inactivation of C3, C5, C6, C7, and the C3b inactivator, but not C8 and C9. Final concentrations as low as 0.5 mM in serum caused inactivation of 12 to 64% of the C3 after 8 hr at 37°C.
D R, Schultz, P I, Arnold
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Complement inactivating proteins and intraspecies venom variation in Crotalus oreganus helleri
Toxicon, 2007Complement inactivating properties were detected in venom from the southern California distribution of Crotalus oreganus helleri (Southern Pacific Rattlesnake). This activity showed strong geographic bias to the San Bernardino Mountain range, and venom from this area reacted strongly with Fraction 5 antiserum (AF5). However, venoms from the San Jacinto
Jennifer D, Jurado +6 more
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Antibody-complement-mediated cytotoxicity is enhanced by ribosome-inactivating proteins.
The Journal of Immunology, 1985Abstract The antibody-mediated cytotoxicity of complement can be increased by the ribosome-inactivating proteins gelonin and PAP-S. Treatment of human lymphoid cells that express CALLA with an anti-CALLA monoclonal antibody, J5, and then with rabbit complement, leaves about 6% of the cells alive.
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Abstract Vaccinia virus complement control protein (VCP) is a virulence determinant of vaccinia virus that helps protect the virus from the complement attack of the host. To characterize the interaction of VCP with C3 and C4 and understand the mechanism by which VCP inactivates complement, we have expressed VCP in a yeast expression ...
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Abstract Radioiodinated β1H was demonstrated to bind to sheep EAC4b, EAC4,2,3b and EC3b, but not to E, EA, EAC4,2 or to C3bINA and β1H treated EC3b. This binding was dependent upon the C3b concentration on the surface of the cells and could be inhibited by unlabeled β1H, free C3b or high concentrations of Factor B.
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