Results 211 to 220 of about 228,991 (253)
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Complement inhibition in C3 glomerulopathy
Seminars in Immunology, 2016C3 glomerulopathy (C3G) describes a spectrum of glomerular diseases defined by shared renal biopsy pathology: a predominance of C3 deposition on immunofluorescence with electron microscopy permitting disease sub-classification. Complement dysregulation underlies the observed pathology, a causal relationship that is supported by well described studies ...
Carla M, Nester, Richard J H, Smith
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Paramyosin inhibits complement C1
The Journal of Immunology, 1992Abstract We report here the results of studies showing that inhibition of C is a property of several invertebrate paramyosins. Paramyosins from Taenia solium, Schistosoma mansoni, and the mussel Mytilus edulis bind polymeric collagen and can be isolated from crude extracts of tissues by collagen affinity.
J P, Laclette +7 more
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With complements:
SummaryC3 is a key complement protein, located at the nexus of all complement activation pathways. Extracellular, tissue, cell‐derived, and intracellular C3 plays critical roles in the immune response that is dysregulated in many diseases, making it an attractive therapeutic target.
Martin Kolev +4 more
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Artificial inhibition of the complement system
Russian Journal of Bioorganic Chemistry, 2007A great number of natural substances affect the complement system in addition to its natural regulators. Among the complement effectors, the most important are inhibitors of the activation cascade. The necessity of searching for preparations capable of a purposeful effect on complement by inhibition of single stages of the activation cascade and ...
L V, Kozlov +3 more
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Complement Inhibition in Xenotransplantation–Where Should the Complement Cascade be Inhibited?
XenotransplantationABSTRACT Clinical gene‐edited pig organ xenotransplantation has recently become a reality, but some problems remain. The transgenic expression of human complement‐regulatory proteins in the pig organs is now an accepted means of reducing the impact of complement activation, and immunosuppressive therapy based on CD40/CD154 co ...
Akihiro Maenaka +2 more
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The Role of Complement Inhibition in PNH
Hematology, 2008AbstractParoxysmal nocturnal hemoglobinuria (PNH) is a rare, chronic, debilitating, acquired disorder that most frequently presents in early adulthood and usually continues throughout the life of a patient. PNH results in the death of approximately half of affected individuals, mainly through thrombotic complications, and until recently had no specific
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Interaction of Collagen with Serum Complement: Inhibition of Complement-Mediated Hemolysis
International Archives of Allergy and Applied Immunology, 2009Collagens from various vertebrate tissues were tested for their ability to consume complement (C) activity upon incubation in human serum or with isolated components of complement. 10 of 12 collagens tested had anticomplementary activity. The heat-denatured form of collagen, gelatin, was found weakly anticomplementary, but elastin was found inactive in
M, Takahashi +2 more
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Inhibition of the Lytic Effect of Guinea Pig Complement by Rabbit Complement
The Journal of Immunology, 1969Summary A sensitized target cell, either a rat peritoneal mast cell or a sheep erythrocyte, when exposed to normal rabbit complement or heat-inactivated rabbit complement, becomes resistant to lysis by guinea pig complement. The inhibition of lysis observed by pretreatment of sensitized sheep erythrocytes with rabbit complement is due to
R A, Kempf, I, Gigli, K F, Austen
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Engineering of human complement component C3 for catalytic inhibition of complement
Immunology Letters, 2005As a novel therapeutic approach in complement-mediated pathologies, we recently developed a human C3 derivative capable of obliterating functional complement by a catalytic, non-inhibitory mechanism. In this derivative, the C-terminal region of hC3 was substituted by a 275 amino acid sequence derived from the corresponding sequence of cobra venom ...
Johanna, Kölln +2 more
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Therapeutic Inhibition of the Complement System
Pharmacological Reviews, 1998The use of powerful methodologies in molecular biology, biochemistry, and physiology in the last 2 decades had led to impressive progress in our understanding of the mechanisms of complement activation and its role as either a protective or a pathogenic factor in human disease.
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