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Complement activation and inhibition: a delicate balance
Trends in Immunology, 2009Complement is part of the innate immune defence and not only recognizes microbes but also unwanted host molecules to enhance phagocytosis and clearance. This process of opsonisation must be tightly regulated to prevent immunopathology. Endogenous ligands such as dying cells, extracellular matrix proteins, pentraxins, amyloid deposits, prions and DNA ...
Sjöberg, A P, Trouw, L A, Blom, A M
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Inhibition of Complement Fixation by Human Serum
The Journal of Immunology, 1962Summary Assays for inhibition of fixation of gpC′ were described. The inhibitory activity of human sera was found to vary, but inhibitory activity was significantly elevated in sera of individuals having rheumatoid arthritis. Fractionation of a number of sera of healthy donors by DEAE cellulose chromatography revealed two ...
R, HEIMER +4 more
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Therapeutic Complement Inhibition
2000Excessive complement activation significantly contributes to the pathogenesis of a large number of inflammatory diseases, including ischemia/reperfusion injury, sepsis, and multiple organ failure syndrome. Current strategies to interfere with the deleterious action of complement include the application of endogenous soluble complement inhibitors (C1 ...
Katrin Jurianz, Michael Kirschfink
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Complement‐Inhibiting Activity of Seminal Plasma
American Journal of Reproductive Immunology, 1984ABSTRACT: Human seminal plasma has an anticomplement effect that can be measured by a standard immune hemolytic assay. We found that about 20% of samples lack complement‐inhibiting activity. To determine the anatomical origin of a complement inhibitor, inhibition of hemolysis was measured in seminal plasma samples that were primarily of prostatic ...
T H, Tarter, N J, Alexander
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Therapeutic Complement Inhibition: New Developments
Seminars in Thrombosis and Hemostasis, 2010Activation of the complement system significantly contributes to the pathogenesis of various acute and chronic inflammatory diseases. Current strategies to inhibit complement include the replacement or substitution of endogenous soluble complement inhibitors (e.g., C1 inhibitor [C1 inh], recombinant soluble complement receptor 1, TP10), the ...
Woodruff, Emlen +2 more
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Inhibition of the Serine Proteases of the Complement System
2012Proteases play important roles in human physiology and pathology. The complement system is a proteolytic cascade, where serine proteases activate each other by limited proteolysis in a strictly ordered manner. Serine proteases are essential in both the initiation and the amplification of the cascade. Since uncontrolled complement activation contributes
Péter, Gál +4 more
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Experimental Inhibition of Complement
1969Four methods are available to elucidate the biological significance of the serum-complement system: 1. The demonstration of complement components at the site of the immunological event. 2. Investigation with animals possessing a genetic C defect. 3. Experiments with anticomplement substances and 4.
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Inhibition of Complement Fixation by Rabbit Serum
The Journal of Immunology, 1960Summary The fixation of guinea pig complement by aggregates of rabbit antibody against ovalbumin and ovalbumin is impeded by normal rabbit serum. The inhibitory effect of rabbit serum is a function of the γ-globulin fraction. Prolonged storage in the cold, or heating at 56–65°C for 1 hr or less have no significant effect on this activity
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Inhibition of complement activation by IgG4 antibodies.
Clinical and experimental immunology, 1986Prolonged exposure to antigens may result in high IgG4 antibody titres as was shown in a previous paper (Aalberse et al., 1983b). In novice bee keepers, a shift in the IgG1/IgG4 ratio of the response against phospholipase-A (PLA; a major component of bee venom) occurred.
van der Zee, J. S. +2 more
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