Results 251 to 260 of about 1,596,091 (292)
Some of the next articles are maybe not open access.
The Role of Complement Inhibition in PNH
Hematology, 2008AbstractParoxysmal nocturnal hemoglobinuria (PNH) is a rare, chronic, debilitating, acquired disorder that most frequently presents in early adulthood and usually continues throughout the life of a patient. PNH results in the death of approximately half of affected individuals, mainly through thrombotic complications, and until recently had no specific
openaire +2 more sources
Therapeutic Inhibition of the Complement System
Pharmacological Reviews, 1998The use of powerful methodologies in molecular biology, biochemistry, and physiology in the last 2 decades had led to impressive progress in our understanding of the mechanisms of complement activation and its role as either a protective or a pathogenic factor in human disease.
openaire +2 more sources
Inhibition of the Lytic Effect of Guinea Pig Complement by Rabbit Complement
The Journal of Immunology, 1969Summary A sensitized target cell, either a rat peritoneal mast cell or a sheep erythrocyte, when exposed to normal rabbit complement or heat-inactivated rabbit complement, becomes resistant to lysis by guinea pig complement. The inhibition of lysis observed by pretreatment of sensitized sheep erythrocytes with rabbit complement is due to
R A, Kempf, I, Gigli, K F, Austen
openaire +2 more sources
Engineering of human complement component C3 for catalytic inhibition of complement
Immunology Letters, 2005As a novel therapeutic approach in complement-mediated pathologies, we recently developed a human C3 derivative capable of obliterating functional complement by a catalytic, non-inhibitory mechanism. In this derivative, the C-terminal region of hC3 was substituted by a 275 amino acid sequence derived from the corresponding sequence of cobra venom ...
Johanna, Kölln +2 more
openaire +2 more sources
Therapeutic Complement Inhibition
2000Excessive complement activation significantly contributes to the pathogenesis of a large number of inflammatory diseases, including ischemia/reperfusion injury, sepsis, and multiple organ failure syndrome. Current strategies to interfere with the deleterious action of complement include the application of endogenous soluble complement inhibitors (C1 ...
Katrin Jurianz, Michael Kirschfink
openaire +1 more source
Interaction of Collagen with Serum Complement: Inhibition of Complement-Mediated Hemolysis
International Archives of Allergy and Applied Immunology, 2009Collagens from various vertebrate tissues were tested for their ability to consume complement (C) activity upon incubation in human serum or with isolated components of complement. 10 of 12 collagens tested had anticomplementary activity. The heat-denatured form of collagen, gelatin, was found weakly anticomplementary, but elastin was found inactive in
M, Takahashi +2 more
openaire +2 more sources
Complement activation and inhibition: a delicate balance
Trends in Immunology, 2009Complement is part of the innate immune defence and not only recognizes microbes but also unwanted host molecules to enhance phagocytosis and clearance. This process of opsonisation must be tightly regulated to prevent immunopathology. Endogenous ligands such as dying cells, extracellular matrix proteins, pentraxins, amyloid deposits, prions and DNA ...
Sjöberg, A P, Trouw, L A, Blom, A M
openaire +3 more sources
Inhibition of Complement Fixation by Human Serum
The Journal of Immunology, 1962Summary Assays for inhibition of fixation of gpC′ were described. The inhibitory activity of human sera was found to vary, but inhibitory activity was significantly elevated in sera of individuals having rheumatoid arthritis. Fractionation of a number of sera of healthy donors by DEAE cellulose chromatography revealed two ...
R, HEIMER +4 more
openaire +2 more sources
Inhibition of the Serine Proteases of the Complement System
2012Proteases play important roles in human physiology and pathology. The complement system is a proteolytic cascade, where serine proteases activate each other by limited proteolysis in a strictly ordered manner. Serine proteases are essential in both the initiation and the amplification of the cascade. Since uncontrolled complement activation contributes
Péter, Gál +4 more
openaire +2 more sources
Experimental Inhibition of Complement
1969Four methods are available to elucidate the biological significance of the serum-complement system: 1. The demonstration of complement components at the site of the immunological event. 2. Investigation with animals possessing a genetic C defect. 3. Experiments with anticomplement substances and 4.
openaire +1 more source