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Response to "Features of Postpartum Hemorrhage-Associated Thrombotic Microangiopathy and Role of Short-Term Complement Inhibition": Still a Long Way to Go. [PDF]
Kidney Int RepRafat C, Mesnard L, Luque Y.
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Immediate and sustained terminal complement inhibition with ravulizumab in patients with anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder. [PDF]
Front NeurolOrtiz S +9 more
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Transfusion and Apheresis Science, 2012
The complement system is an important part of the innate immune system. Complement plays a crucial role in the pathophysiology of many disorders. Despite the pivotal role of the complement system, an approved targeted inhibitor of a complement factor became available only recently.
Hubert, Schrezenmeier +1 more
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The complement system is an important part of the innate immune system. Complement plays a crucial role in the pathophysiology of many disorders. Despite the pivotal role of the complement system, an approved targeted inhibitor of a complement factor became available only recently.
Hubert, Schrezenmeier +1 more
openaire +2 more sources
Complement inhibition in C3 glomerulopathy
Seminars in Immunology, 2016C3 glomerulopathy (C3G) describes a spectrum of glomerular diseases defined by shared renal biopsy pathology: a predominance of C3 deposition on immunofluorescence with electron microscopy permitting disease sub-classification. Complement dysregulation underlies the observed pathology, a causal relationship that is supported by well described studies ...
Carla M, Nester, Richard J H, Smith
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Strategies of therapeutic complement inhibition
Molecular Immunology, 2006The involvement of complement in the pathogenesis of a great number of partly life threatening diseases defines the importance to develop inhibitors which specifically interfere with its deleterious action. Endogenous soluble complement-inhibitors, antibodies or low molecular weight antagonists, either blocking key proteins of the cascade reaction or ...
Tom E, Mollnes, Michael, Kirschfink
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Paramyosin inhibits complement C1
The Journal of Immunology, 1992Abstract We report here the results of studies showing that inhibition of C is a property of several invertebrate paramyosins. Paramyosins from Taenia solium, Schistosoma mansoni, and the mussel Mytilus edulis bind polymeric collagen and can be isolated from crude extracts of tissues by collagen affinity.
J P, Laclette +7 more
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Artificial inhibition of the complement system
Russian Journal of Bioorganic Chemistry, 2007A great number of natural substances affect the complement system in addition to its natural regulators. Among the complement effectors, the most important are inhibitors of the activation cascade. The necessity of searching for preparations capable of a purposeful effect on complement by inhibition of single stages of the activation cascade and ...
L V, Kozlov +3 more
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Complement Inhibition in Xenotransplantation–Where Should the Complement Cascade be Inhibited?
XenotransplantationABSTRACT Clinical gene‐edited pig organ xenotransplantation has recently become a reality, but some problems remain. The transgenic expression of human complement‐regulatory proteins in the pig organs is now an accepted means of reducing the impact of complement activation, and immunosuppressive therapy based on CD40/CD154 co ...
Akihiro Maenaka +2 more
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With complements:
SummaryC3 is a key complement protein, located at the nexus of all complement activation pathways. Extracellular, tissue, cell‐derived, and intracellular C3 plays critical roles in the immune response that is dysregulated in many diseases, making it an attractive therapeutic target.
Martin Kolev +4 more
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